Molecular epidemiology of an outbreak of multidrug-resistant Enterobacter aerogenes infections and in vivo emergence of imipenem resistance

Journal of Clinical Microbiology

Volumn 35, Issue 1, 1997, Pages 152-160

  De Gheldre, Yves ^a   Maes, Nicole ^a   Rost, Francis ^a   De Ryck, Rafael ^a   Clevenbergh, Philippe ^a   Vincent, Jean Louis ^a   Struelens, Marc J ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; ANTIBIOTIC AGENT; AZTREONAM; CEFAZOLIN; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CIPROFLOXACIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; PIPERACILLIN; TEMOCILLIN; TOBRAMYCIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; ENTEROBACTER AEROGENES; ENTEROBACTER INFECTION; EPIDEMIC; FEMALE; HUMAN; INTENSIVE CARE UNIT; MALE; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

BACTERIA (MICROORGANISMS); ENTEROBACTER AEROGENES;

EID: 0031060006     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/jcm.35.1.152-160.1997     Document Type: Article

References (34)

1. Chow, J. W., and D. M. Shlaes. 1991. Imipenem resistance associated with the loss of a 40 kDa outer membrane protein of Enterobacter aerogenes. J. Antimicrob. Chemother. 28:499-504.
2. Davin-Regli, A., D. Monnet, P. Saux, C. Bosi, R. Charrel, A. Barthelemy, and C. Bollet. 1996. Molecular epidemiology of Enterobacter aerogenes acquisition: one year prospective study in two intensive care units. J. Clin. Microbiol. 34:1474-1480.
3. Davin-Regli, A., P. Saux, C. Bollet, F. Gouin, and P. De Micco. 1996. Investigation of outbreaks of Enterobacter aerogenes colonisation and infection in intensive care units by random amplification of polymorphic DNA. J. Med. Microbiol. 44:89-98.
4. de Champs, C., D. Sirot, C. Chanal, M. C. Poupart, M. P. Dumas, and J. Sirot. 1991. Concomitant dissemination of three extended-spectrum betalactamases among different Enterobacteriaceae isolated in a French hospital. J. Antimicrob. Chemother. 27:441-457.
5. de Champs, C., C. Henquell, D. Guelon, D. Sirot, N. Gazuy, and J. Sirot. 1993. Clinical and bacteriological study of nosocomial infections due to Enterobacter aerogenes resistant to imipenem. J. Clin. Microbiol. 31:123-127.
6. Delmée, M., C. Nonhoff, L. Dancsa, and M. J. Struelens. 1995. Trends in prevalence of resistance to fluoroquinolones and other antimicrobials among gram-negative bacteria and staphylococci isolated in eleven Belgian hospitals. Comparison 1991-1993. In Abstracts of the 15̀me Réunion Interdisciplinaire de Chimiothérapie Antiinfectieuse 1995.
7. Ehrhardt, A. F., C. C. Sanders, K. S. Thomson, C. Watanakunakorn, and L. Trujillano-Martin. 1993. Emergence of resistance to imipenem in Enterobacter isolates masquerading as Klebsiella pneumoniae during therapy with imipenem/cilastatin. Clin. Infect. Dis. 17:120-122.
8. Garner, J. S., W. R. Jarvis, T. G. Emori, T. C. Horan, and J. M. Hughes. 1988. CDC definitions for nosocomial infections. Am. J. Infect. Control 16:128-140.
9. Gaston, M. A. 1988. Enterobacter: an emerging nosocomial pathogen. J. Hosp. Infect. 11:197-208.
10. Gaston, M. A., M. A. Strickland, B. A. Ayling-Smith, and T. L. Pitt. 1989. Epidemiological typing of Enterobacter aerogenes. J. Clin. Microbiol. 27:564-565.
11. Georghiou, P. R., R. J. Hamill, C. E. Wright, J. Versalovic, T. Koeuth, D. A. Watson, and J. Lupski. 1995. Molecular epidemiology of infections due to Enterobacter aerogenes: identification of hospital outbreak-associated strains by molecular techniques. Clin. Infect. Dis. 20:84-94.
12. Grattard, F., B. Pozzetto, L. Tabard, M. Petit, A. Ros, and O. G. Gaudin. 1995. Characterization of nosocomial strains of Enterobacter aerogenes by arbitrarily primed - PCR analysis and ribotyping. Infect. Control Hosp. Epidemiol. 16:224-230.
13. Hopkins, J. M., and K. J. Towner. 1990. Enhanced resistance to cefotaxime and imipenem associated with outer membrane protein alterations in Enterobacter aerogenes. J. Antimicrob. Chemother. 25:49-55.
14. Hunter, P. R., and M. A. Gaston. 1988. Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. J. Clin. Microbiol. 26:2465-2466.
15. Jarroux, E., L. Collet, O. Bellon, E. Lagier, M. Miquel, F. Grimont, and H. Chardon. 1995. Enterobacter aerogenes producteur de céphalosporinase déréprimée et de bétalactamase à spectre étendu. Intérêt du céfépime et du cefpirome pour la détection lors d'une épidémie hospitalière en Provence. In Abstracts of the 15ème Réunion Interdisciplinaire de Chimiothérapie Antiinfectieuse 1995.
16. Kerr, K. G. 1994. The rap on REP PCR-based typing systems. Rev. Med. Microbiol. 5:233-244.
17. Lee, E. H., M. H. Nicolas, M. D. Kitzis, G. Pialoux, E. Collatz, and L. Gutmann. 1991. Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem. Antimicrob. Agents Chemother. 35:1093-1098.
18. Livermore, D. M. 1995. ß-Lactamases in laboratory and clinical resistance. Clin. Microbiol. Rev. 8:557-584.
19. Maes, P., and R. Vanhoof. 1992. A 56-month prospective surveillance study on the epidemiology of aminoglycoside resistance in a Belgian general hospital. Scand. J. Infect. Dis. 24:495-501.
20. Manian, F. A., L. Meyer, J. Jenne, A. Owen, and T. Taff. 1996. Loss of antimicrobial susceptibility in aerobic gram negative bacilli repeatedly isolated from patients in intensive care units. Infect. Control Hosp. Epidemiol. 17:222-226.
21. Meyers, H. B., E. Fontanilla, and L. Mascola. 1988. Risk factors for development of sepsis in a hospital outbreak of Enterobacter aerogenes. Am. J. Infect. Control 16:118-122.
22. National Committee for Clinical Laboratory Standards. 1993. Performance standards for antimicrobial disk susceptibility tests, 5th ed. Approved standard M2-A5. National Committee for Clinical Laboratory Standards, Villanova, Pa.
23. National Committee for Clinical Laboratory Standards. 1993. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 3rd ed. Approved standard M7-A3. National Committee for Clinical Laboratory Standards, Villanova, Pa.
24. Neu, H. C. 1992. Resistance of Pseudomonas aeruginosa to imipenem. Infect. Control Hosp. Epidemiol. 13:7-9.
25. Neuwirth, C., E. Siebor, J. Lopez. A. Pechinot, and A. Kazmierzak. 1996. Outbreak of TEM-24 producing Enterobacter aerogenes in an intensive care unit and dissemination of the extended-spectrum β-lactamase to other members of the family Enterobacteriaceae. J. Clin. Microbiol. 34:76-79.
26. Panhotra, B. R., G. Bhardwaj, H. U. Nagash, and B. Desai. 1989. Isolation and survival of gentamicin resistant Enterobacter aerogenes on fingertips of hospital personnel. Zentralbl, Hyg. Umweltmed. 188:331-335.
27. Struelens, M. J., F. Rost, A. Deplano, A. Maas, V. Schwam, E. Serruys, and M. Cremer. 1993. Pseudomonas aeruginosa and Enterobacteriaceae bacteremia after biliary endoscopy: an outbreak investigation using DNA macrorestriction analysis. Am. J. Med. 95:489-497.
28. Struelens, M. J., E. Carlier, N. Maes, E. Serruys, W. G. V. Quint, and A. Van Belkum. 1993. Nosocomial colonization and infection with multiresistant Acinetobacter baumannii: outbreak delineation using DNA macrorestriction analysis and PCR-fingerprinting. J. Hosp. Infect. 25:15-32.
29. Tzouvelekis, L. S., E. Tzelepi, A. F. Mentis, A. C. Vatopoulos, and A. Tsakris. 1992. Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability. FEMS Microbiol. Lett. 74:195-199.
30. Tzouvelekis, L. S., E. Tzelepi, M. E. Kaufmann, and A. F. Mentis. 1994. Consecutive mutations leading to the emergence in vivo of imipenem resistance in a clinical strain of Enterobacter aerogenes. J. Med. Microbiol. 40: 403-407.
31. Van Belkum, A., M. J. Struelens, and W. Quint. 1993. Typing of Legionella pneumophila strains by polymerase chain reaction-mediated DNA fingerprinting. J. Clin. Microbiol. 31:2198-2200.
32. Van Belkum, A. 1994. DNA fingerprinting of medically important microorganisms by use of PCR. Clin. Microbiol. Rev. 7:174-184.
33. Versalovic, J., T. Koeuth, and J. R. Lupski. 1991. Distribution of repetitive DNA sequences in eubacteria and application to fingerprinting of bacterial genomes. Nucleic Acids Res. 19:6823-6831.
34. Vincent, J. L., D. J. Bihari, P. M. Suter, H. A. Bruining, J. White, M. H. Nicolas-Chanoine, M. Wolff, R. C. Spencer, and M. Hemmer for the EPIC International Advisory Committee. 1995. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European prevalence of infection in intensive care (EPIC) study. JAMA 274:639-644.