Cross-linking and sequence specific alkylation of DNA by aziridinyl quinones. 2. Structure requirements for sequence selectivity

Journal of Medicinal Chemistry

Volumn 40, Issue 3, 1997, Pages 357-361

  Hargreaves, Rob H J ^a   Mayalarp, Stephen P ^a   Butler, John ^a   McAdam, Simon R ^b   O'Hare, C Caroline ^b   Hartley, John A ^b  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,5,6 TETRAAZIRIDINYL 1,4 BENZOQUINONE; 2,5 DIAZIRIDINYL 3 (4 METHYLPHENYL) 1,4 BENZOQUINONE; 2,5 DIAZIRIDINYL 3 PHENYL 1,4 BENZOQUINONE; 2,5 DIAZIRIDINYL 3,6 DIMETHYL 1,4 BENZOQUINONE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHRONIC MYELOID LEUKEMIA; COMPUTER MODEL; CYTOPATHOGENIC EFFECT; DNA SEQUENCE; DRUG CONFORMATION; DRUG DNA INTERACTION; DRUG EFFECT; DRUG SPECIFICITY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

EID: 0031059420     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960492j     Document Type: Article

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