Kinetics of Fas-induced apoptosis in thymic organ culture

Journal of Clinical Immunology

Volumn 17, Issue 1, 1997, Pages 74-84

  Zhou, Tong ^a   Fleck, Martin ^a   Müeller Ladner, Ulf ^a   Yang, Pingar ^a   Wang, Zheng ^a   Gay, Steffen ^a   Matsumoto, Shigeru ^a   Mountz, John D ^a,b  

^a The University of Alabama at Birmingham   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

apoptosis; Fas ligand; T cells; thymic organ culture

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; FAS LIGAND; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; FEMALE; FLOW CYTOMETRY; KINETICS; MOUSE; MUTANT; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; THYMUS;

ANIMALS; ANTIBODIES; ANTIGENS, CD95; APOPTOSIS; CELL DIFFERENTIATION; FEMALE; KINETICS; MICE; MICE, INBRED C57BL; MICE, INBRED MRL LPR; ORGAN CULTURE TECHNIQUES; RNA, MESSENGER; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0031059219     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027392613714     Document Type: Article

References (38)

1. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243, 1991
2. Suda T, Takahashi T, Golstein P, Nagata S: Molecular cloning and expression of the Fas ligand: A novel member of the tumor necrosis factor family. Cell 75:1169-1178, 1993
3. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S: Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (Lond) 356:314-317, 1992
4. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S: Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969-976, 1994
5. Russell JH, Rush B, Weaver C, Wang R: Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci USA 90:4409-4413, 1993
6. Alderson MR, Armitage RJ, Maraskovsky E, Tough TW ,Roux E, Schooley K, Ramsdell F, Lynch DH: Fas transduces activation signals in normal human T lymphocytes. J Exp Med 178:2231-2236, 1993
7. Singer GG, Abbas AK: The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365-371, 1994
8. Dheln J, Walczak H, Baumler C, Debatin K-M, Krammer PH: Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373:438-441, 1995
9. Brunner T, Mogil RJ, LaFace D, Yoo NJ, Manboubl A, Echeverre F, Martin J, Force WR, Lynch DH, Ware CF, Green DR: Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373:441-444, 1995
10. Ju S-T, Panka DJ, Cul H, Ettinger R, El-Khatib M, Sherr DH, Stanger BZ, Marshak-Rothestein A: Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444-447, 1995
11. + thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain. MRL-lprl lpr. Proc Natl Acad Sci USA 90:10340-10344, 1993
12. Ogasawa J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S: Lethal effect of the anti-Fas antibody in mice. Nature (Lond) 364:806-809, 1993
13. Andjelic S, Drappa J, Lacy E, Elkon KB, Nikolic-Zugic J: The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes. Int Immunol 6:73-79, 1994
14. + thymocytes by the anti-Fas antibody. J Exp Med 181:485-491, 1995
15. Kotzin BL, Babcock SK, Herron LR: Deletion of potentially self-reactive T cell receptor specificities in L3T4 , Lyt-2 T cells of lpr mice. J Exp Med 168:2221-2232, 1988
16. + and abnormal lpr and gld cell populations. J Exp Med 170:1869-1872, 1989
17. Zhou T, Bluethmann H, Eldridge J, Brockhaus M, Berry K, Mountz JD: Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice. J Immunol 147:466-474, 1991
18. Sidman CL, Marshall JD, von Boehmer H: Transgenic T cell receptor interactions in the lymphoproliferativc and autoimmune syndromes of lpr and gld mutant mice. Eur J Immunol 22:499-504, 1992
19. Mountz JD, Smith TM, Toth KS: Altered expression of self-reactive TCR Vβ regions in autoimmune mice. J Immunol 144: 2159-2166, 1990
20. Zhou T, Mountz JD, Edwards III CK, Berry K, Bluethmann H: Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice. J Exp Med 176:1063-1072, 1992
21. Cohen PL, Eisenberg RA: Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol 9:243-269, 1991
22. Steinberg AD, Roths JB, Murphy ED, Steinberg RT, Raveche ES: Effects of thymectomy or androgen administration upon the auto-immune disease of MRL/MP-lpr/lpr mice. J Immunol 125:871-882, 1980
23. Theofilopoulos AN, Balderas RS, Shawler DL, Lee S, Dixon FJ: Influence of thymic genotype on the SLE-like disease and T cell proliferation of MRL/MP-lpr/lpr mice. J Exp Med 153:1405-1414, 1981
24. + T cells in MRL-lpr/lpr mice. J Immunol 150:3651-3667, 1993
25. Guvrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:492-501, 1992
26. Schmid I, Uittenbogaart CH, Keld B, Giorgi JV: A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry. J Immunol Methods 170:145-157, 1994
27. Schmid I, Uittenbogaart CH, Giorgi JV: Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry 15:12-20, 1994
28. 35S and digoxigenin-labeled RNA and oligonucleotide probes for in situ hybridization. Histochemistry 98:217-228, 1992
29. Pearse M, Wu L, Egerton M, Wilson A, Shortman K, Scollay RA: Murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor. Proc Natl Acad Sci USA 86:1614-1618, 1989
30. Godffrey DI, Kennedy J, Suda T, Zlotnik A: A developmental pathway involving four phenotypically and functionally distinct subsets of CD3 CD4 CD8 triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol 150: 4244-4252, 1993
31. von Boehmer H: Positive selection of lymphocytes. Cell 76:219-228, 1994
32. Nossal GJV: Negative selection of lymphocytes. Cell 76:229-239, 1994
33. Budd RC, Van Houten N, Clements J, I'ixter PF: Parallels in T lymphocyte development between lpr and normal mice. Semin Immunol 6:43-48, 1994
34. + thymic precursor. J Immunol 151:1086-1096, 1993
35. Rothstein TL, Wang JKM, Panka DJ, Foote LC, Wang Z, Stanger B, Cul H, Ju S-T. Marshak-Rothestein A: Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells. Nature 374:163-165, 1995
36. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K-I, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, Loh DY: Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506-1510, 1995
37. Wadsworth S, Yui K, Siegel RM, Tenenholz DE, Hirsch JA, Greene MI: Origin and selection of peripheral CD4 CD8 T cells bearing α/β T cell antigen receptors in autoimmune gld mice. Eur J Immunol 20:723-734, 1990
38. Singer PA, Theofilopoulos AN: Novel origin of lpr and gld cells and possible implications in autoimmunity. J Autoimmun 3:123-138, 1990