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Volumn 15, Issue 3, 1997, Pages 908-914

Fluorouracil plus racemic leucovorin versus fluorouracil combined with the pure l-isomer of leucovorin for the treatment of advanced colorectal cancer: A randomized phase III study

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUMFOLINAT; FLUOROURACIL; FOLINIC ACID; UNCLASSIFIED DRUG;

EID: 0031059138     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1997.15.3.908     Document Type: Article
Times cited : (41)

References (34)
  • 1
    • 0026657812 scopus 로고
    • Chemotherapy for metastatic colorectal cancer
    • Mayer RJ: Chemotherapy for metastatic colorectal cancer. Cancer 70:1414-1424, 1992
    • (1992) Cancer , vol.70 , pp. 1414-1424
    • Mayer, R.J.1
  • 2
    • 0027461840 scopus 로고
    • Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer
    • Scheithauer W, Rosen H, Kornek GV, et al: Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. Br Med J 306:752-755, 1993
    • (1993) Br Med J , vol.306 , pp. 752-755
    • Scheithauer, W.1    Rosen, H.2    Kornek, G.V.3
  • 3
    • 0026762968 scopus 로고
    • Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: A randomized trial
    • The Nordic Gastrointestinal Tumour Adjuvant Therapy Group: Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: A randomized trial. J Clin Oncol 10:904-911, 1992
    • (1992) J Clin Oncol , vol.10 , pp. 904-911
  • 4
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
    • Advanced Colorectal Cancer Meta-Analysis Project: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol 10:896-903, 1992
    • (1992) J Clin Oncol , vol.10 , pp. 896-903
  • 5
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • Moertel CG: Chemotherapy for colorectal cancer. N Engl J Med 330:1136-1142, 1990
    • (1990) N Engl J Med , vol.330 , pp. 1136-1142
    • Moertel, C.G.1
  • 6
    • 0029873191 scopus 로고    scopus 로고
    • Biochemical modulation of fluoropyrimidines: Is there an optimal (6R,S) leucovorin dose and schedule?
    • Doroshow JH: Biochemical modulation of fluoropyrimidines: Is there an optimal (6R,S) leucovorin dose and schedule? J Natl Cancer Inst 88:393-395, 1996
    • (1996) J Natl Cancer Inst , vol.88 , pp. 393-395
    • Doroshow, J.H.1
  • 7
    • 0023705723 scopus 로고
    • Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells
    • Keyomarsi K, Moran RG: Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J Biol Chem 263:14402-14409, 1988
    • (1988) J Biol Chem , vol.263 , pp. 14402-14409
    • Keyomarsi, K.1    Moran, R.G.2
  • 8
    • 0018264544 scopus 로고
    • Lack of stereospecifity at carbon 6 of methyl-tetrahydrofolate transport in Ehrlich ascites tumor cells. Carrier-mediated transport of both stereoisomers
    • White JC, Bailey BD, Goldman ID: Lack of stereospecifity at carbon 6 of methyl-tetrahydrofolate transport in Ehrlich ascites tumor cells. Carrier-mediated transport of both stereoisomers. J Biol Chem 253:242-245, 1978
    • (1978) J Biol Chem , vol.253 , pp. 242-245
    • White, J.C.1    Bailey, B.D.2    Goldman, I.D.3
  • 9
    • 0018690601 scopus 로고
    • Stereospecifity at carbon 6 of formyltetra-hydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro
    • Sirotnak FM, Chello PL, Moccio DM, et al: Stereospecifity at carbon 6 of formyltetra-hydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro. Biochem Pharmacol 28:2993-2997, 1979
    • (1979) Biochem Pharmacol , vol.28 , pp. 2993-2997
    • Sirotnak, F.M.1    Chello, P.L.2    Moccio, D.M.3
  • 10
    • 0342549300 scopus 로고
    • Interaction of methotrexate and citrovorum factor at folyl-polyglutamate synthetase
    • abstr
    • Sato JK, Moran RG: Interaction of methotrexate and citrovorum factor at folyl-polyglutamate synthetase. Proc Am Assoc Cancer Res 25:312, 1984 (abstr)
    • (1984) Proc Am Assoc Cancer Res , vol.25 , pp. 312
    • Sato, J.K.1    Moran, R.G.2
  • 11
    • 0025981649 scopus 로고
    • Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin
    • Romanini A, Lin JT, Niedzwiecki D, et al: Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin. Cancer Res 51:789-793, 1991
    • (1991) Cancer Res , vol.51 , pp. 789-793
    • Romanini, A.1    Lin, J.T.2    Niedzwiecki, D.3
  • 12
    • 0024439093 scopus 로고
    • Pharmacokinetics of diastereoisomers of (6R,S)-folinic acid (leucovorin) in humans during constant high-dose intravenous infusion
    • Newman EM, Straw JA, Doroshow JH: Pharmacokinetics of diastereoisomers of (6R,S)-folinic acid (leucovorin) in humans during constant high-dose intravenous infusion. Cancer Res 49:5755-5760, 1989
    • (1989) Cancer Res , vol.49 , pp. 5755-5760
    • Newman, E.M.1    Straw, J.A.2    Doroshow, J.H.3
  • 13
    • 0024379691 scopus 로고
    • Lack of interference by the unnatural isomer of 5-formyltetra-hydrofolate with the effects of the natural isomer in leucovorin preparations
    • Bertrand R, Jolivet J: Lack of interference by the unnatural isomer of 5-formyltetra-hydrofolate with the effects of the natural isomer in leucovorin preparations. J Natl Cancer Inst 15:1175-1177, 1989
    • (1989) J Natl Cancer Inst , vol.15 , pp. 1175-1177
    • Bertrand, R.1    Jolivet, J.2
  • 14
    • 0343469030 scopus 로고    scopus 로고
    • Serum and tissue levels of 1-folinic acid (FA) after iv bolus of either racemic (d,1) FA or pure 1-enantiomer (1-FA)
    • abstr
    • Schüller J, Czejka M, Piertrzak C, et al: Serum and tissue levels of 1-folinic acid (FA) after iv bolus of either racemic (d,1) FA or pure 1-enantiomer (1-FA). Proc Am Soc Clin Oncol 15:175, 1996 (abstr)
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 175
    • Schüller, J.1    Czejka, M.2    Piertrzak, C.3
  • 15
    • 0027294042 scopus 로고
    • Pharmacokinetics and in vitro studies of 1-leucovorin. Comparison with the d and d,1-leucovorin
    • Zittoun J: Pharmacokinetics and in vitro studies of 1-leucovorin. Comparison with the d and d,1-leucovorin. Ann Oncol 4:1-5, 1993 (suppl 2)
    • (1993) Ann Oncol , vol.4 , Issue.2 SUPPL. , pp. 1-5
    • Zittoun, J.1
  • 16
    • 0026507592 scopus 로고
    • Fluorouracil combined with the pure (6S)-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: A phase I-II study
    • Machover D, Grison X, Goldschmidt E, et al: Fluorouracil combined with the pure (6S)-stereoisomer of folinic acid in high doses for treatment of patients with advanced colorectal carcinoma: A phase I-II study. J Natl Cancer Inst 84:321-327, 1992
    • (1992) J Natl Cancer Inst , vol.84 , pp. 321-327
    • Machover, D.1    Grison, X.2    Goldschmidt, E.3
  • 17
    • 0026006962 scopus 로고
    • Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
    • Poon MA, O'Connell MJ, Wieand HS, et al: Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 9:1967-1972, 1991
    • (1991) J Clin Oncol , vol.9 , pp. 1967-1972
    • Poon, M.A.1    O'Connell, M.J.2    Wieand, H.S.3
  • 18
    • 0028175144 scopus 로고
    • Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
    • Buroker TR, O'Connell MJ, Wieand HS, et al: Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 12:14-20, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 14-20
    • Buroker, T.R.1    O'Connell, M.J.2    Wieand, H.S.3
  • 19
    • 0029813416 scopus 로고    scopus 로고
    • Weekly high-dose leucovorin versus low-dose leucovorin combined with fluorouracil in advanced colorectal cancer: Results of a randomized multicenter trial
    • Jäger E, Heike M, Bernhard H, et al: Weekly high-dose leucovorin versus low-dose leucovorin combined with fluorouracil in advanced colorectal cancer: Results of a randomized multicenter trial. J Clin Oncol 14:2274-2279, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2274-2279
    • Jäger, E.1    Heike, M.2    Bernhard, H.3
  • 20
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study
    • Lokich JJ, Ahlgren JD, Gullo JJ, et al: A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study. J Clin Oncol 7:425-432, 1989
    • (1989) J Clin Oncol , vol.7 , pp. 425-432
    • Lokich, J.J.1    Ahlgren, J.D.2    Gullo, J.J.3
  • 21
    • 0016799829 scopus 로고
    • Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial
    • Pocock SJ, Simon R: Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics 31:103-115, 1975
    • (1975) Biometrics , vol.31 , pp. 103-115
    • Pocock, S.J.1    Simon, R.2
  • 22
    • 0003486933 scopus 로고
    • WHO offset publication no. 48. Geneva, Switzerland, World Health Organization
    • World Health Organization: Handbook for reporting results of cancer treatment. WHO offset publication no. 48. Geneva, Switzerland, World Health Organization, 1979
    • (1979) Handbook for Reporting Results of Cancer Treatment
  • 23
    • 33845382806 scopus 로고
    • Non-parametric estimation from incomplete observations
    • Kaplan EL, Meier P: Non-parametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 24
    • 0000957062 scopus 로고
    • Asymptotically efficient invariant procedures
    • Peto R, Peto J: Asymptotically efficient invariant procedures. J R Stat Soc A 135:185-206, 1972
    • (1972) J R Stat Soc A , vol.135 , pp. 185-206
    • Peto, R.1    Peto, J.2
  • 25
    • 0024564697 scopus 로고
    • Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer
    • Arbuck SG: Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer. Cancer 63:1036-1044, 1989
    • (1989) Cancer , vol.63 , pp. 1036-1044
    • Arbuck, S.G.1
  • 26
    • 84871467324 scopus 로고
    • Twenty-four hours weekly infusion of 5-fluorouracil (5-FU) and oral 6S-leucovorin (L-LV) in advanced colorectal cancer
    • abstr
    • Nobile MT, Sanguineti O, Barzacchi MC, et al: Twenty-four hours weekly infusion of 5-fluorouracil (5-FU) and oral 6S-leucovorin (L-LV) in advanced colorectal cancer. Proc Am Soc Clin Oncol 12:227, 1993 (abstr)
    • (1993) Proc Am Soc Clin Oncol , vol.12 , pp. 227
    • Nobile, M.T.1    Sanguineti, O.2    Barzacchi, M.C.3
  • 27
    • 0027239619 scopus 로고
    • L-folinic acid and 5-fluorouracil in the treatment of advanced breast cancer: A phase II study
    • Zaniboni A, Meriggi, F, Arcangeli G, et al: L-folinic acid and 5-fluorouracil in the treatment of advanced breast cancer: A phase II study. Ann Oncol 4:41-43, 1993 (suppl 2)
    • (1993) Ann Oncol , vol.4 , Issue.2 SUPPL. , pp. 41-43
    • Zaniboni, A.1    Meriggi, F.2    Arcangeli, G.3
  • 28
    • 84871472373 scopus 로고
    • Phase II clinical and pharmacology study of cisplatin (CDDP), 5-fluorouracil (5-FU), and 1-leucovorin (1-LV) induction therapy of locally advanced resectable squamous cell carcinoma of the head and neck (SCCHN)
    • abstr
    • Dimery I, Shirinian M, Goepfert H, et al: Phase II clinical and pharmacology study of cisplatin (CDDP), 5-fluorouracil (5-FU), and 1-leucovorin (1-LV) induction therapy of locally advanced resectable squamous cell carcinoma of the head and neck (SCCHN). Proc Am Soc Clin Oncol 12:279, 1993 (abstr)
    • (1993) Proc Am Soc Clin Oncol , vol.12 , pp. 279
    • Dimery, I.1    Shirinian, M.2    Goepfert, H.3
  • 29
    • 0342549297 scopus 로고    scopus 로고
    • A prospective randomized trial of intensive course 5-FU combined with a the 1-isomer of intravenous leucovorin, b oral (d,1) leucovorin or c intravenous (d,1) leucovorin for the treatment of advanced colorectal cancer: A North Central Cancer Treatment Group trial
    • abstr
    • Goldberg RM, O'Connell MJ, Wieand HS, et al: A prospective randomized trial of intensive course 5-FU combined with a) the 1-isomer of intravenous leucovorin, b) oral (d,1) leucovorin or c) intravenous (d,1) leucovorin for the treatment of advanced colorectal cancer: A North Central Cancer Treatment Group trial. Proc Am Soc Clin Oncol 15:207, 1996 (abstr)
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 207
    • Goldberg, R.M.1    O'Connell, M.J.2    Wieand, H.S.3
  • 30
    • 0027238857 scopus 로고
    • Phase I trial of a 5-day infusion of 1-leucovorin plus daily bolus 5-fluorouracil in patients with advanced gastrointestinal malignancies
    • Valone FH, Gandara DR, Luce JA, et al: Phase I trial of a 5-day infusion of 1-leucovorin plus daily bolus 5-fluorouracil in patients with advanced gastrointestinal malignancies. Cancer Chemother Pharmacol 32:215-220, 1993
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 215-220
    • Valone, F.H.1    Gandara, D.R.2    Luce, J.A.3
  • 31
    • 0023520170 scopus 로고
    • A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma
    • Petrelli N, Herrera L, Rustum Y, et al: A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 5:1559-1565, 1987
    • (1987) J Clin Oncol , vol.5 , pp. 1559-1565
    • Petrelli, N.1    Herrera, L.2    Rustum, Y.3
  • 32
    • 0023874456 scopus 로고
    • A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma
    • Erlichman C, Fine S, Wong A, et al: A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 6:469-475, 1988
    • (1988) J Clin Oncol , vol.6 , pp. 469-475
    • Erlichman, C.1    Fine, S.2    Wong, A.3
  • 33
    • 0030048024 scopus 로고
    • A phase II trial of 5-fluorouracil and 1-leucovorin in patients with metastatic colorectal cancer
    • Erlichmann C, Fine S, Kerr I, et al: A phase II trial of 5-fluorouracil and 1-leucovorin in patients with metastatic colorectal cancer. Am J Clin Oncol 19:26-31, 1966
    • (1966) Am J Clin Oncol , vol.19 , pp. 26-31
    • Erlichmann, C.1    Fine, S.2    Kerr, I.3
  • 34
    • 0029584454 scopus 로고
    • Thymidylate synthase inhibition, a dead end?
    • Herrmann R: Thymidylate synthase inhibition, a dead end? Eur J Cancer 31A:1919-1920, 1995
    • (1995) Eur J Cancer , vol.31 A , pp. 1919-1920
    • Herrmann, R.1


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