Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats

Brain Research

Volumn 749, Issue 2, 1997, Pages 354-357

  Oka, Takakazu ^a   Hosoi, Masako ^a   Oka, Kae ^a   Hori, Tetsuro ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

analgesia; brain; central nervous system; hyperalgesia; pain; prostaglandin E2; wide dynamic range neuron

Indexed keywords

PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HYPERALGESIA; HYPOALGESIA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; TRIGEMINAL NERVE;

ACTIVITY CYCLES; ANIMALS; CEREBRAL VENTRICLES; INJECTIONS, INTRAVENTRICULAR; MALE; NEURONS; PAIN; PROSTAGLANDINS E; RATS; RATS, WISTAR; SKIN; TIME FACTORS; TRIGEMINAL NUCLEI;

EID: 0031058820     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01421-7     Document Type: Article

References (15)

1. 1 receptor gene, Eur. J. Biochem., 231 (1995) 809-814.
2. Coleman., R.A., Smith, W.L. and Narumiya, S., VIII. International union of pharmacology classification of prostanoid receptors: properties, distribution and structure of the receptors and their subtypes, Pharmacol. Rec., 46 (1994) 205-229.
3. Fukushima, T. and Kerr, F.W.L., Organization of trigeminothalamic tracts and other thalamic afferent systems of the brainstem in the rat: presence of gelatinosa neurons with thalamic connections, J. Camp. Neural., 183 (1979) 169-184.
4. 2, Pflugers Arch., 350 (1974) 123-134.
5. 2α to conscious mice, Eur. J. Pharmacol.,122 (1986) 173-179.
6. 2 binding sites in rat brain using quantitative autoradiography, Brain Res., 581 (1992) 292-298.
7. Milton, A.S. and Wendlandt. S., Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanesthetized cats and rabbits, J. Physiol. (Land.), 218 (1971) 325-336.
8. 2 on pain and inflammation, Jpn. J. Pharmacol., 33 (1983) 264-266.
9. Oka, T., Aou, S. and Hori, T., Intracerebroventricular injection of interleukin-1 β enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats, Brain Res., 656 (1994) 236-244.
10. 3 receptors, Brain Res., 663 (1994) 287-292.
11. 2-induced hyperthermia in rats. Am. J. Physiol., 267 (1994) R289-R294.
12. 2 induces bimodal effects on nociceptive neuronal responses in the trigeminal nucleus caudalis in rats: the possible involvement of different types of EP-receptors, Neurosci. Res., 20 (1996) S218.
13. 2α in the rat. I. Behavioral, antinociceptive and anticonvulsant actions of intraventricular prostaglandins in the rat, Psychophannacology, 50 (1976) 89-94.
14. 3 in the mouse nervous system, Neuroscience, 62 (1994) 919-928.
15. Ushikubi, F., Hirata, M. and Narumiya, S., Molecular biology of prostanoid receptors: an overview. J. Lipid Mediators Cell Signalling. 12 (1995) 343-359.