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M. Bate, Martinez-Arias A. Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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The Drosophila sine oculis locus encodes a homeodomain-containing protein required for development of the entire visual system
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Cheyette BNR, Green PJ, Martin K, Garren H, Hartenstein V, Zipursky SL. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for development of the entire visual system. Neuron. 12:1994;977-996.
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0028019609
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Sine oculis is a homeobox gene required for Drosophila visual system development
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Serikaku MA, O'Tousa JE. sine oculis is a homeobox gene required for Drosophila visual system development. Genetics. 138:1994;1137-1150.
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Serikaku, M.A.1
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Dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila
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Mardon G, Solomon NM, Rubin GM. dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development. 120:1994;3473-3486.
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Mardon, G.1
Solomon, N.M.2
Rubin, G.M.3
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9
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The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye
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Bonini NM, Leiserson WM, Benzer S. The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye. Cell. 72:1993;379-395.
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Bonini, N.M.1
Leiserson, W.M.2
Benzer, S.3
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10
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0028944665
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Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
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of outstanding interest. Ectopic expression of eyeless results in the formation of fully differentiated eyes on the legs, wings and antennae of Drosophila, demonstrating that eyeless, the Pax-6 homolog of flies, acts as a master control gene for eye morphogenesis.
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Halder G, Callaerts P, Gehring WJ. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. of outstanding interest Science. 267:1995;1788-1792 Ectopic expression of eyeless results in the formation of fully differentiated eyes on the legs, wings and antennae of Drosophila, demonstrating that eyeless, the Pax-6 homolog of flies, acts as a master control gene for eye morphogenesis.
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Science
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Halder, G.1
Callaerts, P.2
Gehring, W.J.3
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11
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Ectopic eye development in Drosophila induced by directed dachshund expression
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of outstanding interest. Targeted expression of dachshund in Drosophila is sufficient to direct ectopic retinal development in head, thorax and legs, similar to the effects of ectopic eyeless expression [10]. The authors show further that dachshund and eyeless induced the expression of each other and that dachsund is required for eyeless-induced ectopic retinal development. These results suggest that the control of eye development requires, even at the highest regulatory level, the complex interaction of multiple genes.
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Shen W, Mardon G. Ectopic eye development in Drosophila induced by directed dachshund expression. of outstanding interest Development. 124:1997;45-52 Targeted expression of dachshund in Drosophila is sufficient to direct ectopic retinal development in head, thorax and legs, similar to the effects of ectopic eyeless expression [10]. The authors show further that dachshund and eyeless induced the expression of each other and that dachsund is required for eyeless-induced ectopic retinal development. These results suggest that the control of eye development requires, even at the highest regulatory level, the complex interaction of multiple genes.
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(1997)
Development
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Shen, W.1
Mardon, G.2
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12
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0026345992
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Mouse Small eye results from mutations in a paired-liked homeobox-containing gene
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Hill RE, Favor J, Hogan BLM, Ton CCT, Saunders GF, Hanson IM, Prosser J, Jordan T, Hastie ND, Van Heyningen V. Mouse Small eye results from mutations in a paired-liked homeobox-containing gene. Nature. 345:1991;522-525.
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Nature
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Hill, R.E.1
Favor, J.2
Hogan, B.L.M.3
Ton, C.C.T.4
Saunders, G.F.5
Hanson, I.M.6
Prosser, J.7
Jordan, T.8
Hastie, N.D.9
Van Heyningen, V.10
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13
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0026315044
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Positional cloning and charactrization of a paired box and homebox containing gene from the aniridia region
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Ton CCT, Hirvonen H, Miwa H, Weil MM, Monaghan P, Jordan T, Van Heyningen V, Hastie ND, Meijers-Heijboer H, Drechsler M, et al. Positional cloning and charactrization of a paired box and homebox containing gene from the aniridia region. Cell. 67:1991;1059-1074.
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Ton, C.C.T.1
Hirvonen, H.2
Miwa, H.3
Weil, M.M.4
Monaghan, P.5
Jordan, T.6
Van Heyningen, V.7
Hastie, N.D.8
Meijers-Heijboer, H.9
Drechsler, M.10
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14
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0029617682
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Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development
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of special interest. Reports the isolation of Six3, a member of the Sixlso subclass of homeobox genes. Six3 is expressed in the anterior border of the developing neural plate and later on in eye development.
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Oliver G, Mailhos A, Wehr R, Copeland NG, Jenkins NA, Gruss P. Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. of special interest Development. 121:1995;4045-4055 Reports the isolation of Six3, a member of the Sixlso subclass of homeobox genes. Six3 is expressed in the anterior border of the developing neural plate and later on in eye development.
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(1995)
Development
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Oliver, G.1
Mailhos, A.2
Wehr, R.3
Copeland, N.G.4
Jenkins, N.A.5
Gruss, P.6
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On the evolution of eyes: Would you like it simple or compound?
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Zuker CS. On the evolution of eyes: would you like it simple or compound? Science. 265:1994;742-743.
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Science
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Zuker, C.S.1
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16
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0029131888
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New perspectives on eye evolution
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of special interest. In this review, the authors discuss the evolutionary implications of the finding that the vertebrate gene Pax-6 and the fly gene eyeless are molecularly and functionally conserved.
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Halder G, Callaerts P, Gehring WJ. New perspectives on eye evolution. of special interest Curr Opin Genet Dev. 5:1995;602-609 In this review, the authors discuss the evolutionary implications of the finding that the vertebrate gene Pax-6 and the fly gene eyeless are molecularly and functionally conserved.
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Curr Opin Genet Dev
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Halder, G.1
Callaerts, P.2
Gehring, W.J.3
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17
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0027323503
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The embryonic development of the Drosophila visual system
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Green P, Hartenstein AY, Hartenstein V. The embryonic development of the Drosophila visual system. Cell Tissue Res. 273:1993;583-598.
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Cell Tissue Res
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Green, P.1
Hartenstein, A.Y.2
Hartenstein, V.3
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0028131581
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Pattern formation in the visual centers of the Drosophila brain: Wingless acts via decapentaplegic to specify the dorsovental axis
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Kaphingst K, Kunes S. Pattern formation in the visual centers of the Drosophila brain: wingless acts via decapentaplegic to specify the dorsovental axis. Cell. 78:1994;437-448.
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Cell
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Kaphingst, K.1
Kunes, S.2
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19
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0028839101
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Mininbrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila
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of special interest. The recently identified minibrain (mnb) gene encodes a serine/threonine kinase that shares sequence similarities with cyclin-dependent protein kinases. In mnb mutants, the size of the optic lobe is greatly reduced, which the authors attribute to the abnormal spacing of neuroblasts in the outer proliferation center.
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Tejedor F, Zhu XR, Kaltenbach E, Ackermann A, Baumann A, Canal I, Heisenberg M, Fischbach KF, Pongs O. mininbrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila. of special interest Neuron. 14:1995;287-301 The recently identified minibrain (mnb) gene encodes a serine/threonine kinase that shares sequence similarities with cyclin-dependent protein kinases. In mnb mutants, the size of the optic lobe is greatly reduced, which the authors attribute to the abnormal spacing of neuroblasts in the outer proliferation center.
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Neuron
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, pp. 287-301
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Tejedor, F.1
Zhu, X.R.2
Kaltenbach, E.3
Ackermann, A.4
Baumann, A.5
Canal, I.6
Heisenberg, M.7
Fischbach, K.F.8
Pongs, O.9
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20
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0028880557
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The division abnormally delayed (dally) gene: A putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila
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of special interest. The dally gene, which encodes a putative integral membrane proteoglycan, is required for both divisions of the lamina precursor cells (LPCs) in the lamina anlage. In dally mutants, the first division is delayed, whereas the second, photoreceptor-triggered division does not take place at all. Interestingly, LPCs are still able to terminally differentiate as neurons.
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Nakato H, Futch TA, Selleck SB. The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila. of special interest Development. 121:1995;3687-3702 The dally gene, which encodes a putative integral membrane proteoglycan, is required for both divisions of the lamina precursor cells (LPCs) in the lamina anlage. In dally mutants, the first division is delayed, whereas the second, photoreceptor-triggered division does not take place at all. Interestingly, LPCs are still able to terminally differentiate as neurons.
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(1995)
Development
, vol.121
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Nakato, H.1
Futch, T.A.2
Selleck, S.B.3
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21
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0027788042
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The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina
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Heberlein U, Wolff T, Rubin GM. The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. Cell. 75:1993;913-926.
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Cell
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Heberlein, U.1
Wolff, T.2
Rubin, G.M.3
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22
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0027741258
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The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
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Ma C, Zhou Y, Beachy PA, Moses K. The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell. 75:1993;927-938.
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Cell
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Ma, C.1
Zhou, Y.2
Beachy, P.A.3
Moses, K.4
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The influence of retinal innervation on neurogenesis in the first optic ganglion of Drosophila
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Selleck SB, Steller H. The influence of retinal innervation on neurogenesis in the first optic ganglion of Drosophila. Neuron. 6:1991;83-99.
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Neuron
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Selleck, S.B.1
Steller, H.2
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Regulation of the G1 - S transition in postembryonic neuronal precursors by axon ingrowth
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Selleck SB, Gonzalez C, Glover DM, White K. Regulation of the G1 - S transition in postembryonic neuronal precursors by axon ingrowth. Nature. 355:1992;253-255.
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Nature
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Selleck, S.B.1
Gonzalez, C.2
Glover, D.M.3
White, K.4
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25
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0030576531
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Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain
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of outstanding interest. Hedgehog, which is expressed in differentiating photoreceptors in the eye and is required for the induction of differentiation in precursor cells lying anteriorly, is transmitted along retinal axons and serves as an inductive signal in the brain. Hedgehog is required for the completion of the terminal cell cycle of lamina precursor cells, as well as for some aspects of their terminal differentiation.
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Huang Z, Kunes S. Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain. of outstanding interest Cell. 86:1996;411-422 Hedgehog, which is expressed in differentiating photoreceptors in the eye and is required for the induction of differentiation in precursor cells lying anteriorly, is transmitted along retinal axons and serves as an inductive signal in the brain. Hedgehog is required for the completion of the terminal cell cycle of lamina precursor cells, as well as for some aspects of their terminal differentiation.
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(1996)
Cell
, vol.86
, pp. 411-422
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Huang, Z.1
Kunes, S.2
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0028872403
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Evidence that pioneer olfactory axons regulate telencephalon cell cycle kinetics to induce the formation of the olfactory bulb
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Gong Q, Shipley MT. Evidence that pioneer olfactory axons regulate telencephalon cell cycle kinetics to induce the formation of the olfactory bulb. Neuron. 14:1995;91-101.
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Neuron
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Gong, Q.1
Shipley, M.T.2
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0026453672
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Generation and early differentiation of glial cells in the first optic ganglion of Drosophila melanogaster
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Winberg ML, Perez SE, Steller H. Generation and early differentiation of glial cells in the first optic ganglion of Drosophila melanogaster. Development. 115:1992;903-911.
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Development
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Winberg, M.L.1
Perez, S.E.2
Steller, H.3
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Migration of glia along photoreceptor axons in the developing Drosophila eye
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Choi K-W, Benzer S. Migration of glia along photoreceptor axons in the developing Drosophila eye. Neuron. 12:1994;423-431.
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Neuron
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Choi, K.-W.1
Benzer, S.2
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29
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0028916322
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Defective glia induce neuronal apoptosis in the repo visual system of Drosophila
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of special interest. The reversed polarity (repo) gene is a pan-glial marker for the visual system. Mutations in repo cause abnormal terminal diffrentiation of the glia and lead to concomitant apoptosis of lamina neurons and glia, followed by retrograde degeneration of photoreceptors in the retina.
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Xiong WC, Montell C. Defective glia induce neuronal apoptosis in the repo visual system of Drosophila. of special interest Neuron. 14:1995;581-590 The reversed polarity (repo) gene is a pan-glial marker for the visual system. Mutations in repo cause abnormal terminal diffrentiation of the glia and lead to concomitant apoptosis of lamina neurons and glia, followed by retrograde degeneration of photoreceptors in the retina.
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Neuron
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Xiong, W.C.1
Montell, C.2
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Independent guidance of retinal axons in the developing visual system of Drosophila
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Kunes S, Wilson C, Steller H. Independent guidance of retinal axons in the developing visual system of Drosophila. J Neurosci. 13:1993;752-767.
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J Neurosci
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Kunes, S.1
Wilson, C.2
Steller, H.3
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31
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Competition and position-dependent targeting in the development of the Drosophila R7 visual projections
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Ashley JA, Katz FN. Competition and position-dependent targeting in the development of the Drosophila R7 visual projections. Development. 120:1994;1537-1547.
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(1994)
Development
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Ashley, J.A.1
Katz, F.N.2
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Topographically specific effects of ELf-1 on retinal axon guidance in vitro and retinal axon mapping in vivo
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Nakamoto M, Cheng H, Friedman GC, McLaughlin T, Hansen MJ, Yoon CH, O'Leary DDM, Flanagan JG. Topographically specific effects of ELf-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell. 86:1996;755-766.
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Cell
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Nakamoto, M.1
Cheng, H.2
Friedman, G.C.3
McLaughlin, T.4
Hansen, M.J.5
Yoon, C.H.6
O'Leary, D.D.M.7
Flanagan, J.G.8
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33
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Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps
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Tessier-Lavigne M. Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell. 82:1995;345-348.
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Cell
, vol.82
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Tessier-Lavigne, M.1
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34
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0029082312
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In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases
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Drescher U, Kremoser C, Handwerker C, Löschinger J, Noda M, Bonhoeffer F. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell. 82:1995;359-370.
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Cell
, vol.82
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Drescher, U.1
Kremoser, C.2
Handwerker, C.3
Löschinger, J.4
Noda, M.5
Bonhoeffer, F.6
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35
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Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map
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Cheng HJ, Nakamoto M, Bergemann AD, Flanagan JG. Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell. 82:1995;371-381.
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Cell
, vol.82
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Cheng, H.J.1
Nakamoto, M.2
Bergemann, A.D.3
Flanagan, J.G.4
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36
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0028890451
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Mutations disrupting neuronal connectivity in the Drosophila visual system
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of special interest. In an elegant histological screen, recessive mutations on the X and third chromosome that disrupt retinal connectivity were isolated. Genes were identified as candidates for playing direct roles in axonal outgrowth, target recognition and retinotopy.
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Martin KA, Poeck B, Roth H, Ebens AJ, Ballard LC, Zipursky SL. Mutations disrupting neuronal connectivity in the Drosophila visual system. of special interest Neuron. 14:1995;229-240 In an elegant histological screen, recessive mutations on the X and third chromosome that disrupt retinal connectivity were isolated. Genes were identified as candidates for playing direct roles in axonal outgrowth, target recognition and retinotopy.
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Neuron
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Martin, K.A.1
Poeck, B.2
Roth, H.3
Ebens, A.J.4
Ballard, L.C.5
Zipursky, S.L.6
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37
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0029943447
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Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein
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of outstanding interest. Molecular analysis of the dreadlocks (dock) gene, which was identified on the basis of its mutant phenotype and is characterized by defects in retinal axon guidance and targeting. The Dock protein is highly related to the human proto-oncogene Nck and is highly enriched in photoreceptor growth cones in the target region, suggesting that it is involved in signal transduction in the growth cone.
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Garrity PA, Rao Y, Salecker I, McGlade J, Pawson T, Zipursky SL. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. of outstanding interest Cell. 85:1996;639-650 Molecular analysis of the dreadlocks (dock) gene, which was identified on the basis of its mutant phenotype and is characterized by defects in retinal axon guidance and targeting. The Dock protein is highly related to the human proto-oncogene Nck and is highly enriched in photoreceptor growth cones in the target region, suggesting that it is involved in signal transduction in the growth cone.
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(1996)
Cell
, vol.85
, pp. 639-650
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Garrity, P.A.1
Rao, Y.2
Salecker, I.3
McGlade, J.4
Pawson, T.5
Zipursky, S.L.6
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38
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0027767583
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The irregular chiasm C-roughest locus of Drosophila, which affects axonal projectios and programmed cell death, encodes a novel immunoglobulin-like protein
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Ramos RGP, Igloi GL, Lichte B, Baumann U, Maier D, Schneider T, Bradstätter JH, Fröhlich A, Fischbach KF. The irregular chiasm C-roughest locus of Drosophila, which affects axonal projectios and programmed cell death, encodes a novel immunoglobulin-like protein. Genes Dev. 7:1993;2533-2547.
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Ramos, R.G.P.1
Igloi, G.L.2
Lichte, B.3
Baumann, U.4
Maier, D.5
Schneider, T.6
Bradstätter, J.H.7
Fröhlich, A.8
Fischbach, K.F.9
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39
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0029166015
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Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons
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of special interest. The irreC - rst protein is an immunoglobulin superfamily member that mediates homophilic adhesion in vitro. The protein is expressed in a highly dynamic pattern in subsets of young axons throughout the visual system. Ubiquitous expressions of the protein results in phenotypes similar to complete loss of protein, suggesting that spatial restriction of expression is essential for the function of the molecule.
-
Schneider T, Reiter C, Eule E, Bader B, Lichte B, Nie Z, Schimansky T, Ramos RGP, Fischbach KF. Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons. of special interest Neuron. 15:1995;259-271 The irreC - rst protein is an immunoglobulin superfamily member that mediates homophilic adhesion in vitro. The protein is expressed in a highly dynamic pattern in subsets of young axons throughout the visual system. Ubiquitous expressions of the protein results in phenotypes similar to complete loss of protein, suggesting that spatial restriction of expression is essential for the function of the molecule.
-
(1995)
Neuron
, vol.15
, pp. 259-271
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-
Schneider, T.1
Reiter, C.2
Eule, E.3
Bader, B.4
Lichte, B.5
Nie, Z.6
Schimansky, T.7
Ramos, R.G.P.8
Fischbach, K.F.9
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40
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0029818996
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Genetic analysis of Laminin A in Drosophila: Extracellular matrix containing laminin A is required for ocellar axon pathfinding
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of special interest. Partial loss-of-function mutations in laminin A are examined for axon pathfinding defects in the sensory neurons of the fly head. Ocellar pioneer axons fail to project to their target in the brain, while neighboring mechanosensory axons project normally, suggesting that differential expression of laminin receptors by different sensory growth cones may regulate pathway choice.
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