Alkylxanthine adenosine antagonists and epileptiform activity in rat hippocampal slices in vitro

Experimental Brain Research

Volumn 113, Issue 2, 1997, Pages 303-310

  Chesi, Alexander J R ^a,b   Stone, Trevor W ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adenosine A1 receptor; DPCPX; Hippocampus; Membrane partitioning; Purines; Rat

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; THEOPHYLLINE; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPIKE WAVE; TETANY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; HIPPOCAMPUS; MALE; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; XANTHINES;

EID: 0031058280     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02450328     Document Type: Article

References (66)

1. Alzheimer C, Sutor B, Bruggencate G ten (1989) Transient and selective blockade of adenosine A1-receptors by DPCPX causes sustained epileptiform activity in hippocampal CA3 neurones of guinea pigs. Neurosci Lett 99: 107-112
2. Ault B, Olney MA, Joyner JL, Boyer CE, Notrica MA, Soroko FE, Wang CM (1987) Pro-convulsant actions of theophylline and caffeine in the hippocampus - implications for the management of temporal lobe epilepsy. Brain Res 426: 93-102
3. Bahls FH, Ma KK, Bird TD (1991) Theophylline-associated seizures with "therapeutic" or low toxic serum concentrations: risk factors for serious outcomes in adults. Neurology 41: 1309-1312
4. 2-adrenoceptor agonist - characterization of pharmacological activity in vitro and in vivo. Br J Pharmacol 104: 665-671
5. Baumgold J, Nikodijevic O, Jacobson KA (1992) Penetration of adenosine antagonists into mouse brain as determined by ex vivo binding. Biochem Pharmacol 43: 889-894
6. Bertorelli R, Ferri N, Adami M, Ongini E (1996) Effects of selective agonists and antagonists for A1 or A2a adenosine receptors on sleep waking patterns in rats. Drug Dev Res 37: 65-72
7. Bisserbe JC, Pascal O, Deckert J, Maziere B (1992) Potential use of DPCPX as probe for in vivo localization of brain A1 adenosine receptors. Brain Res 599: 6-12
8. Boissard CG, Gribkoff VK (1993) The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro. Neuropharmacology 32: 149-155
9. Bourne HR, Nicoll R (1993) Molecular machines integrate coincident synaptic signals. Cell 79: 59-68
10. Bruns RF, Fergus JH (1990) Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes. Mol Pharmacol 38: 939-949
11. 3H]NECA in rat striatal membranes. Mol Pharmacol 29: 331-346
12. Bruns RF, Fergus JH, Badger EW, Bristol JA, Santay LA, Hartman JD, Hays SJ, Huang CC (1987) Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Arch Pharmacol 335: 59-63
13. Chen Y, Graham DI, Stone TW (1992) Release of endogenous adenosine and its metabolites by the activation of NMDA receptors in the rat hippocampus in vivo. Br J Pharmacol 106: 632-638
14. Chu NS (1981) Caffeine- and aminophylline-induced seizures. Epilepsia 22: 85-94
15. Collis MG, Hourani SM (1993) Adenosine receptor subtypes. TiPS 14: 360-366
16. Dawid-Milner MS, Silva-Carvalho L, Goldsmith GR, Spyer KM (1994) A potential role of central A1 adenosine receptors in the responses to hypothalamic stimulation in the anaesthesized cat. J Autonom Nerv Syst 49: 15-19
17. Delaney SM, Geiger JD (1996) Brain regional levels of adenosine and adenosine nucleotides in rats killed by high-energy focused microwave irradiation. J Neurosci methods 64: 151-156
18. i in rat ventricular myocytes. BrJ Pharmacol 111: 455-458
19. Dragunow M, Goddard GV, Laverty R (1985) Is adenosine an endogenous anticonvulsant? Epilepsia 26: 480-487
20. Dragunow M, Goddard GV, Laverty R (1987) Proconvulsant effects of theophylline on hippocampal afterdischarges. Exp Neurol 96: 732-735
21. Francis A, Fochtmann L (1994) Caffeine augmentation of electroconvulsive seizures. Psychopharmacology (Berl) 115: 320-324
22. Garaschuk O, Kovalchuk, Krishtal O (1992) Adenosine-dependent enhancement by methylxanthines of excitatory transmission in hippocampus of rats. Neurosci Lett 135: 10-12
23. Gerwins P, Nordstedt C, Fredholm BB (1990) Characterization of adenosine A1 receptors in intact DD1 MF-2 smooth muscle cells. Mol Pharmacol 38: 660-666
24. Griebel R, Saffroy-Spittler M, Misslin R, Remmy D, Vogel E, Bourguignon J (1991) Comparison of the behavioural effects of an adenosine A1/A2-receptor antagonist, CGS 15943A, and an A1-selective antagonist, DPCPX. Psychopharmacology (Berl) 103: 541-544
25. Hansch C, Steward AR, Anderson SM, Bentley D (1968) The parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics. J Med Chem 11: 1-16
26. Herbette LG, Vant Erve YMH, Rhodes DG (1989) Interaction of 1,4-dihydropyridine calcium channel antagonists with biological membranes - lipid bilayer partitioning could occur before drug binding to receptors. J Mol Cell Cardiol 21: 187-201
27. Ishikawa A, Kurihara E, Okada Y (1994) Excitatory effects of adenosine receptor agonists and antagonists on neurotransmission in guinea pig superior collicular slices. Neurosci Lett 171: 129-132
28. Klishin A, Tsintsadze T, Lozovaya N, Krishtal OA (1995) Latent NMDA receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons: Ca(2+)-dependent activation by blocking A(1) adenosine receptors. Proc Natl Acad Sci USA 92: 12431-12435
29. Knight RJ, Bowmer CJ, Yates MS (1993) The diuretic action of DPCPX, a selective A1 adenosine receptor antagonist. Br J Pharmacol 109: 271-277
30. Kostopulos G, Veronikis DK, Efthimiou I (1987) Caffeine blocks absence seizures in the tottering mutant mouse. Epilepsia 28: 415-420
31. Kuan C, Herzer WA, Jackson EK (1992) An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo. J Pharmacol Exp Ther 263: 657-662
32. Lobban M, Shakur Y, Beattie J, Houslay MD (1994) Identification of two splice variant forms of type IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions. Biochem J 304: 399-406
33. Lohse MJ, Klotz KN, Lindenborn-Fotinos J, Reddington M, Schwabe U, Olsson RA (1987) DPCPX - a selective high affinity antagonist radioligand for A1 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 336: 204-210
34. Lurie SN, Coffey CE (1990) Caffeine-modified electroconvulsive therapy in depressed patients with medical illness. J Clin Psychiatry 51: 154-157
35. 2+ current in hippocampal CA3 neurones. Neuron 10: 327-334
36. Morgan PF, Deckert J, Jacobson KA, Marangos PJ, Daly JW (1989) Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC). Life Sci 45: 719-728
37. Mori H, Mizutani T, Yoshimura M, Yamanouchi H, Shimada H (1992) Unilateral brain damage after prolonged hemiconvulsions in the elderly associated with theophylline administration. J Neurol Neurosurg Psychiatry 55: 466-469
38. Müller M, Osten B v., Schmid R, Piegler E, Gerngross I, Buchegger H, Eichler HG (1995) Theophylline kinetics in peripheral tissues in vivo in humans. Naunyn Schmiedebergs Arch Pharmacol 352: 438-441
39. Munakata M, Akaike N (1993) Theophylline affects three different potassium currents in dissociated rat cortical neurones. J Physiol (Lond) 471: 599-616
40. Murray TF, Zhang G, Franklin PH (1993) Manipulation of endogenous adenosine affects seizure susceptibility. Drug Dev Res 28: 410-415
41. Nakagawa Y, Gudenzi M, Mustafa SJ (1986) Calcium entry blocking activity of dilazep and other adenosine potentiating compounds in guinea pig atria. Eur J Pharmacol 122: 51-58
42. Nanoff C, Mitterauer T, Roka F, Hohenegger M, Freissmuth M (1995) Species differences in A1 adenosine receptor/G protein coupling - identification of a membrane protein that stabilizes the association of the receptor/G protein complex. Mol Pharmacol 48: 806-817
43. Norenberg MD, Chu NS (1977) Aminophylline-induced preictal alterations in cortical astrocytes. Exp Neurol 54: 340-351
44. Nowack L, Bregestovski P, Ascher P, Herbert A, Prochianz A (1984) magnesium gates glutamate-activated channels in mouse central neurones. Nature 307: 462-465
45. ++-related A1/A2 adenosine receptor cooperation. Eur J Neurosci 8: 1124-1131
46. Olpe HR, Steinmann MW, Ferrat T, Pozza MF, Greiner K, Brugger F, Froestl W, Mickel SJ, Bittinger H (1993) The actions of orally available GABAb antagonists on GABAergic transmission in vivo and in vitro. Eur J Pharmacol 233: 179-186
47. Palmer TM, Stiles GL (1994) The new biology of adenosine receptors. Adv Enzymol Relat Areas Mol Biol 69: 83-120
48. Parsons WJ, Stiles GL (1987) Heterologous desensitisation of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. J Biol Chem 262: 841-847
49. Parsons WJ, Ramkumar V, Stiles GL (1988) The new cardiotonic agent sulmazole is an adenosine A1 receptor antagonist and functionally blocks the inhibitory regulator Gi. Mol Pharmacol 33:441-448
50. Peters SG, Wochos DN, Peterson GC (1984) Status epilepticus as a complication of concurrent electroconvulsive and theophylline therapy. Mayo Clin Proc 59: 568-570
51. Prater MR, Taylor H, Munshi R, Linden J (1992) Indirect effect of guanine nucleotides on antagonist binding to adenosine receptors - occupation of cryptic binding sites by endogenous vesicular adenosine. Mol Pharmacol 42: 765-772
52. Prince DA, Stevens CF (1992) Adenosine decreases neurotransmitter release at central synapses. Proc Natl Acad Sci USA 89: 8568-8590
53. Rhodes DG, Sarmiento JG, Herbette LG (1985) Kinetics of binding of membrane-active drugs to receptor sites. Diffusion limited rates for a membrane-bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site. Mol Pharmacol 27: 612-623
54. Sakurai T, Okada Y (1992) Excitatory effect of adenosine on neurotransmission and the release of glutamate from hippocampal slices of guinea pig (abstract). J Physiol (Lond) 446: P380
55. Schiemann WP, Walther JM, Buxton ILO (1990) On the ability of endogenous udenosine to regulate purine nucleoside receptor binding of antagonists in smooth muscle cells. J Pharmacol Exp Ther 255: 886-892
56. Starke K, Reimann W, Zumstein A, Hertting G (1978) Effect of dopamine receptor agonists and antagonists on release of dopamine in the rabbit caudate nucleus in vitro. Naunyn Schmiedebergs Arch Pharmacol 305: 27-36
57. Stone TW, Simmonds HA (1991) Purines - basic and clinical aspects. Kluwer, Dordrecht
58. Stroher M, Nanoff C, Schütz W (1989) Differences in the GTP-regulation of membrane-bound and solubilized A1 receptors. Arch Pharmacol 340: 87-92
59. Swartz CM, Lewis RK (1991) Theophyllinc reversal of electroconvulsive therapy (ECT) seizure inhibition. Psychosomatics 32: 47-51
60. Wayman GA, Impey S, Wu Z, Kindsvogel W, Prichard L, Storm DR (1994) Synergistic activation of the type I adenylyl cyelase by Ca2+ and Gs-coupled receptors in vivo. J Biol Chem 269: 25400-25405
61. Weisman RS, Goldfrank LR, Rowland MA (1990) Theophylline. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA (eds) Goldfrank's toxicologic emergencies, 4th edn. Prentice Hall, London, pp 341-347
62. Wood PL, Kim HS, Boyar WC, Hutchison A (1989) Inhibition of nigrostriatal release of dopamine in the rat by adenosine receptor agonists - A1 receptor mediation. Neuropharmacology 28: 21-25
63. Wu YN, Mercuri NB, Johnson SW (1995) Presynaptic inhibition of gamma-aminobutyric acid B-mediated synaptic current by adenosine recorded in vitro in midbrain dopamine neurons. J Pharmacol Exp Ther 273: 576-581
64. Würl P (1994) Lebensgefährliche Coffeinintoxikation unter Verwendung von Kaffee als Rauschmittel. Wien Klin Wochenschr 106: 359-361
65. Young HS, Skita V, Mason RP, Herbette LG (1992) Molecular basis for the inhibition of 1,4-dihydropyridine Ca channel drugs binding to their receptors by a nonspecific site interaction mechanism. Biophys J 61: 1244-1255
66. Zetterstrom T, Vernet L, Ungerstedt U, Tossman U, Jonzon B, Fredholm BB (1982) Purine levels in the intact brain, studied with an implanted perfused hollow fibre. Neurosci Lett 29: 111-115