Synthesis and preliminary in vitro evaluation of a new memantine derivative 1-amino-3-[18F]fluoromethyl-5-methyl-adamantane: A potential ligand for mapping the N-methyl-D-aspartate receptor complex

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 39, Issue 3, 1997, Pages 241-250

  Samnick, Samuel ^a   Ametamey, Simon ^a   Gold, Markus R ^b   Schubiger, Pius A ^a  

^a PAUL SCHERRER INSTITUTE   (Switzerland)

^b Merz + Co   (Germany)

Author keywords

18F; Memantine derivatives; n.c.a. nucleophilic radiofluorination; NMDA receptor; PET

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

18F; ADAMANTANES; IN-VITRO EVALUATION; MEMANTINE; MEMANTINE DERIVATIVE; NCA NUCLEOPHILIC RADIOFLUORINATION; NMDA RECEPTOR; POTENTIAL LIGAND; RADIOFLUORINATION; RECEPTOR COMPLEX;

CHELATION;

ADAMANTANE DERIVATIVE; FLUORINE 18; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENCYCLIDINE;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; FLUORINATION; IN VITRO STUDY; ISOTOPE LABELING; LIPOPHILICITY; NONHUMAN; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY;

EID: 0031057808     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199703)39:3<241::AID-JLCR966>3.0.CO;2-V     Document Type: Article

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