Histologic changes in the intervertebral disc after intradiscal injections of methylprednisolone acetate in rabbits

Spine

Volumn 22, Issue 2, 1997, Pages 127-132

  Aoki, Masayuki ^a   Kato, Fumihiko ^a   Mimatsu, Kentaro ^a   Iwata, Hisashi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

calcification; Dope Medrol; intervertebral disc; intradiscal steroid injection (SIDT); methylprednisolone acetate; polyethylene glycol

Indexed keywords

CORTICOSTEROID; METHYLPREDNISOLONE; METHYLPREDNISOLONE ACEPONATE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIFICATION; CONTROLLED STUDY; CORTICOSTEROID THERAPY; HISTOLOGY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK HERNIA; INTRADISCAL DRUG ADMINISTRATION; LUMBAR DISK HERNIA; MALE; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; RABBIT; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CALCINOSIS; INJECTIONS, SPINAL; INTERVERTEBRAL DISK; LUMBAR VERTEBRAE; MALE; METHYLPREDNISOLONE; METHYLPREDNISOLONE HEMISUCCINATE; MICROSCOPY, ELECTRON; RABBITS; SPINAL DISEASES;

EID: 0031057677     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199701150-00001     Document Type: Article

References (20)

1. Anderson HC, Merker PC, Foug J. Formation of tumors containing bone after intramuscular injection of transformed human amnion cells (FL) into cortisone-treated mice. Am J Pathol 1964;44:507.
2. Anderson HC. Electron microscopic studies of induced cartilage development. J Cell Biol 1967;35:81-101.
3. Anderson HC. Vesicles associated with calcification in the epiphysial cartilage. J Cell Biol 1969;41:59-72.
4. Anderson HC. Osteogenic epithelial mesenchymal cell interactions. Clin Orthop 1976;119:211-24.
5. Bosky AL. Current concepts of the physiology and biochemistry of calcification. Clin Orthop 1981;157:225-57.
6. Chino N, Awad EA, Kottke FJ. Pathology of propylene glycol administered by perineural and intramuscular injection in rats. Arch Phys Med Rehab 1974;55:33-8.
7. Delaney TJ, Rowlingson JC, Carron H, Butler A. Epidural steroid effects on nerves and meninges. Anesth Analog 1980; 58:610-4.
8. Dequesnoy B, Debiais F, Heuline E, et al. Unsatisfactory results of intradiscal injection of triamcinolone hexacetonide in the treatment of sciatica caused by intravertebral disk herniadon. Presse Med 1992;21:1801-4.
9. Feffer HL. Treatment of low back pain and sciatic pain by the injection of hydrocortisone into degenerated intervertebral discs. J Bone Joint Surg [Am] 1956;38:585-92.
10. Feffer HL. Therapeutic intradiscal hydrocortisone: A long term study. Clin Orthop 1969;67:100-4.
11. Graham CE. Chemonucleolysis: A preliminary report on a double blind study comparing chemonucleolysis and intradiscal administration of hydrocortisone in the treatment of backache and sciatica. Orthop Clin North Am 1975;6:1211-7.
12. Johnson A, Ryan MD, Roche J. Depo-Medrol and myelographic arachnoiditis. Med J Aust 1991;155:18-20.
13. Kato F, Mimatsu K, Kawakami N, Ando T. Changes in the intervertebral disc after discography with intradiscal injection of corticosteroids observed by magnetic resonance imaging (MRI). J Neurol Orthop Med Surg 1993;14:210-6.
14. Leao L. Intradiscal injection of hydrocortisone and prednisolone in the treatment of low back pain. Rheumatism 1960; 16:72-7.
15. Menkes CJ, Vallee C, Giraudet-Le-Quintrec JS. Calcification of epidural space after the injection of triamcinolone hexacetonide. Presse Med 1989;18:1707.
16. Muro T. Treatment of lumbar disc herniation by intradiscal injection of corticosteroids: Follow-up study. International Intradiscal Therapy Society Third Annual Meeting, Marbella, Spain, March 7-11, 1990.
17. Nelson AN. Intraspinal therapy using methylprednisolone acetate. Twenty-three years of clinical controversy. Spine 1993; 18:278-86.
18. Roche J. Steroid-induced arachnoiditis. Med J Aust 1984; 140:281-4.
19. Simmonds JW, McMillin JN, Emery SF, Kimmich SJ. Intradiscal steroids. A prospective double-blind clinical trial. Spine 1992;17(Suppl):172-5.
20. Wilkinson HA, Schuman N. Intradiscal corticosteroids in the treatment of lumbar and cervical disc problems. Spine 1980;5:385-9.