Reduced intracellular accumulation of azole antifungal results in resistance in Candida albicans isolate NCPF 3363

FEMS Microbiology Letters

Volumn 147, Issue 2, 1997, Pages 189-193

  Lamb, D C ^a   Kelly, D E ^a   Manning, N J ^b   Kelly, S L ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

azole antifungal; Candida albicans; P450; resistance

Indexed keywords

ANTIFUNGAL AGENT; FLUCONAZOLE; KETOCONAZOLE; PYRROLE DERIVATIVE;

ARTICLE; CANDIDA ALBICANS; DRUG ACCUMULATION; DRUG RESISTANCE; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS, CHRONIC MUCOCUTANEOUS; DRUG RESISTANCE, MICROBIAL; FLUCONAZOLE; KETOCONAZOLE; MICROBIAL SENSITIVITY TESTS; STEROLS;

EID: 0031057360     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(96)00522-8     Document Type: Article

References (14)

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2. Kelly, S.L., Lamb, D.C., Corran, A.C., Baldwin, B.C. and Kelly, D.E. (1995) Mode of action and resistance to azole antifungals associated with the formation of 14α-methylergosta-8,24(28)-dien-3β,6α-diol. Biochem. Biophys. Res. Commun. 207, 910-915.
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5. Vanden Bossche, H., Marichal, P., Gorrens, J., Bellens, D., Moereels, H. and Jannssen, P.A.J. (1990) Mutation in cytochrome P450-dependent 14a-demethylase results in decreased affinity for azole antifungals. Biochem. Soc. Trans. 18, 56-59.
6. Watson, P.F., Rose, M.E., Ellis, S.W., England, H. and Kelly, S.L. (1989) Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals. Biochem. Biophys. Res. Commun. 164, 1170-1175.
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10. Sanglard, D., Kuchler, K., Ischer, F., Pagani, J.L., Monod, M. and Bille, J. (1995) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39, 2378-2386.
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