Interleukin-11 improves survival and reduces bacterial translocation and bone marrow suppression in burned mice

Journal of Pediatric Surgery

Volumn 32, Issue 2, 1997, Pages 312-315

  Schindel, David ^b   Maze, Rodney ^b   Liu, Qui ^b   Williams, David ^b   Grosfeld, Jay ^a  

^a RILEY HOSPITAL FOR CHILDREN   (United States)

^b NONE

Author keywords

bacterial translocation; bone marrow suppression; burn injury; cytokines; growth factors; Interleukin 11

Indexed keywords

BOVINE SERUM ALBUMIN; INTERLEUKIN 11;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BACTERIAL TRANSLOCATION; BONE MARROW SUPPRESSION; BURN; CONFERENCE PAPER; CONTROLLED STUDY; INTESTINE VILLUS; LYMPHOCYTE COUNT; MALE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCALD; SUBCUTANEOUS DRUG ADMINISTRATION; SURVIVAL; THROMBOCYTE COUNT;

EID: 0031057129     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3468(97)90200-1     Document Type: Conference Paper

References (20)

1. Maejima K, Deitch EA, Berg RD: Promotion by burn stress of the translocation of bacteria from the gastrointestinal tracts of mice. Arch Surg 119:166-172, 1984
2. Gamelli RL, He L, Liu H Marrow granulocyte-macrophage progenitor cell response to burn injury as modified by endotoxin and indomethacin. J Trauma 37:339-346, 1994
3. Carter PB, Collins FM: The route of enteric infection in normal mice. J Exp Med 139:1189-1203, 1974
4. Berg RD, Garlington AW: Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 23:403-411, 1979
5. Ryan CM, Bailey SH, Carter EA, et al: Additive effects of thermal injury and infection on gut permeability. Arch Surg 129:325-328, 1994
6. O'Dwyer ST, Michie HR, Ziegler TR, et al: A single dose of endotoxin increases intestinal permeability in healthy humans. Arch Surg 123:1459-1464, 1988
7. Carter EA, Tompkins RG, Schiffrin E, et al: Cutaneous thermal injury alters macronodular permeability of rat small intestine. Surgery 107:335-341, 1990
8. Kalmaz GD, Guest MM. Burn trauma: Role of thrombocytopenia in inhibition of megakaryocytopoiesis. Ann NY Acad 628.396-398, 1991
9. Deitch EA, Winterton J, Berg R: The gut as a portal of entry for bacteremia. Ann Surg 205:681, 1987
10. Deitch EA, Dazhong X, Qi L, et al: Bacterial translocation from the gut impairs systemic immunity. Surgery 109:269-276, 1991
11. Du XX, Williams DA Interleukin-11: A multifactorial growth factor derived from the hematopoietic microenvironment. Blood 83: 2030-2037, 1994
12. McKinley D, Wu Q, Yang-Feng T, et al: Genomic sequence and chromosomal location of human interleukin(IL)-11 gene. Genomics 13 814, 1992
13. Du XX, Doerschuk CM, Orazi A, et al: A bone marrow stromal-derived growth factor, IL-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy. Blood 83 33-37, 1994
14. Du XX, Williams DA: Update on development of Interleukin-11. Curr Opinion Hematol 2:182-188, 1995
15. Liu Q, Du XX, Schindel DT, et al: Trophic effects of interleukin-11 in rats with experimental short bowel syndrome. J Pediatr Surg 31:1047-1051, 1996
16. Carter PB, Collins FM: The route of enteric infection in normal mice. J Exp Med 139:1189-1201, 1974
17. Anderson KC, Morimoto C, Paul SR, et al Interleukin-11 promotes accessory cell dependant B-cell differentiation in humans. Blood 80:2797, 1992
18. Yin T, Schendel P, Yang Y-C Enhancement of in vitro and in vivo antigen-specific antibody responses by Interleukin-11 J Exp Med 175:211-216, 1992
19. Baumann H, Schendel P: Interleukin-11 regulates the hepatic expression of the same plasma protein genes as Interleukin-6. J Biol Chem 266:20424-20427, 1991
20. Du XX, Neben T, Goldman S, et al Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: Acceleration of recovery of peripheral blood neutrophils and platelets Blood 81.27-34, 1993