Growth hormone secretion and synthesis are depressed in obesity- susceptible compared with obesity-resistant rats

Metabolism: Clinical and Experimental

Volumn 46, Issue 2, 1997, Pages 210-216

  Lauterio, Thomas J ^a   Perez, Frank M ^b  

^a Diabetes Institutes Foundation   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONE SYNTHESIS; INSULIN BLOOD LEVEL; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT GAIN;

EID: 0031055899     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90304-8     Document Type: Article

References (46)

1. Colditz GA: Economic costs of obesity. Am J Clin Nutr 55:503S-507S, 1992 (suppl)
2. Ernsberger P, Haskew P: Rethinking Obesity: An Alternative View of Its Health Implications. New York, NY, Human Sciences, 1987, pp 1-81
3. Bray GA: The Obese Patient. Philadelphia, PA, Saunders, 1976, pp 1-36
4. El-Khodary AZ, Ball MF, Stein B, et al: Effect of weight loss on the growth-hormone response to arginine infusion in obesity. J Clin Endocrinol Metab 33:42-48, 1971
5. Glass AR, Burman KD, Dahms WT, et al: Endocrine function in human obesity. Metabolism 30:89-104, 1981
6. Balsamo A, Cassio A, Mandini M, et al: Endocrine aspects of pediatric obesity, in Giorgi PL, Suskind RM, Catassi C (eds): The Obese Child, vol 2. Basel, Switzerland, Karger, 1992, pp 59-68
7. Binnerts A, Deurenberg P, Swart GR, et al: Body composition in growth hormone-deficient adults. Am J Clin Nutr 55:918-923, 1992
8. Kopelman PG, Noonan K: Growth hormone response to low dose intravenous injections of growth hormone releasing factor in obese and normal weight women. Clin Endocrinol (Oxf) 24:157-164, 1986
9. Tanaka K, Inoue S, Numata K, et al: Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine, and L-dopa in obesity. Metabolism 39:892-896, 1990
10. Ball MF, El-Khodary AZ, Canary JJ: Growth hormone response in the thinned obese. J Clin Endocrinol Metab 34:498-511, 1972
11. Crockford PM, Salmon PA: Hormones and obesity: Changes in insulin and growth hormone secretion following surgically induced weight loss. Can Med Assoc J 103:147-150, 1970
12. Rudman D, Feller AG, Cohn L, et al: Effects of human growth hormone on body composition in elderly men. Horm Res 36:73-81, 1991
13. Skaggs SR, Crist DM: Exogenous human growth hormone reduces body fat in obese women. Horm Res 35:19-24, 1991
14. Martin RJ, Harris RBS, Jones DD: Evidence for a central mechanism of obesity in the Zucker fatty rat (fa/fa) (42380). Proc Soc Exp Biol Med 183:1-10, 1986
15. Bestetti G, Abramo F, Guillaume-Gentil C, et al: Changes in the hypothalamic-pituitary-adrenal axis of genetically obese fa/fa rats: A structural, immunocytochemical, and morphometrical study. Endocrinology 126:1880-1887, 1990
16. Plotsky PM, Thrivikraman KV, Watts AG, et al: Hypothalamic-pituitary-adrenal axis function in the Zucker obese rat. Endocrinology 130:1931-1941, 1992
17. Martin RJ, Drewry M, Jewell D, et al: Growth hormone treatment reduces total body fat accumulation in Zucker obese rats. Int J Obes 13:327-335, 1989
18. Johnson PR, Greenwood MRC, Horwitz BA, et al: Animal models of obesity: Genetic aspects. Annu Rev Nutr 11:325-353, 1991
19. Mori T, Inoue S, Egawa M, et al: Impaired growth hormone secretion in VMH lesioned rats. Int J Obes 17:349-353, 1993
20. Dubey AK, Hanukoglu A, Hansen BC, et al: Metabolic clearance rates of synthetic human growth hormone in lean and obese male rhesus monkeys. J Clin Endocrinol Metab 67:1064-1067, 1988
21. Levin BE, Triscari J, Sullivan AC: Altered sympathetic activity during development of diet-induced obesity in rat. Am J Physiol 244:R347-R355, 1983
22. Levin BE, Finnegan MB, Marquet E, et al: Effects of diet and obesity on brown adipose metabolism. Am J Physiol 246:418-425, 1984
23. Lauterio TJ, Bond JP, Ulman EA: Development and characterization of a purified diet to identify obesity-susceptible and -resistant rat populations. J Nutr 124:2172-2178, 1994
24. Steel RGD, Torrie JH: Principles and Procedures of Statistics. New York, NY, McGraw-Hill, 1960, pp 1-481
25. Wilfinger WW, Larsen WJ, Downs TR, et al: An in vitro model for studies of intracellular communication in cultured rat anterior pituitary cells. Tissue Cell 16:483-491, 1984
26. Denef C, Hautekeet E, de Wolf A, et al: Pituitary basophils from immature male and female rats: Distribution of gonadotrophs and thyrotrophs as studied by unit gravity sedimentation. Endocrinology 103:724-730, 1978
27. Kacsoh B, Meyers JS, Crowley WR, et al: Maternal modulation of growth hormone secretion in the neonatal rat: Involvement of mother-offspring interactions. J Endocrinol 124:233-240, 1990
28. 2-adrenergic, somatostatin and growth hormone-releasing hormone systems. J Neuroendocrinol 3:529-537, 1991
29. Bjorntorp P: Abdominal obesity and the metabolic syndrome. Ann Med 24:465-468, 1992
30. Salomon F, Cuneo RC, Hesp R, et al: The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321:1797-1803, 1989
31. Kopelman PG, Noonan K, Goultan R, et al: Impaired growth hormone response to growth hormone releasing factor and insulin-induced hypoglycemia in obesity. Clin Endocrinol (Oxf) 23:87-94, 1985
32. Tanaka K, Inoue S, Shiraki J, et al: Age-related decrease in plasma growth hormone: Response to growth hormone-releasing hormone, arginine, and L-dopa in obesity. Metabolism 40:1257-1262, 1991
33. Astrup A, Buemann B, Western P, et al: Obesity as an adaptation to a high-fat diet: Evidence from a cross-sectional study. Am J Clin Nutr 59:350-355, 1994
34. Tucker LA, Kano MJ: Dietary fat and body fat: A multivariate study of 205 adult females. Am J Clin Nutr 56:616-622, 1992
35. Leidy JW Jr, Romano TM, Millard WJ: Developmental and sex-related changes of the growth hormone axis in lean and obese Zucker rats. Neuroendocrinology 57:213-223, 1993
36. Ahmad I, Finkelstein JA, Downs TR, et al: Obesity-associated decrease in growth hormone-releasing hormone gene expression: A mechanism for reduced growth hormone mRNA levels in genetically obese Zucker rats. Neuroendocrinology 58:332-337, 1993
37. Guillaume-Gentil C, Rohner-Jeanrenaud F, Abramo F, et al: Abnormal regulation of the hypothalamo-pituitary-adrenal axis in the genetically obese fa/fa rat. Endocrinology 126:1873-1879, 1990
38. Ahmad I, Steggles AW, Finkelstein JA: In situ hybridization study of obesity-associated alteration in growth hormone mRNA levels. Int J Obes 16:435-441, 1992
39. Arbona JR, Rahe CH, Kelley RL, et al: Differences in GH secretion from individual somatotropes in rats genetically selected for fast and slow growth. Am J Physiol 263:E748-E751, 1992
40. Ghigo E, Procopia M, Maccario M, et al: Repetitive GHRH administration fails to increase the response to GHRH in obese subjects: Evidence for a somatotrope defect in obesity? Horm Metab Res 25:305-308, 1993
41. Cordido F, Casanueva FF, Dieguez C: Cholinergic receptor activation by pyridostigmine restores growth hormone (GH) responsiveness to GH-releasing hormone administration in obese subjects: Evidence for hypothalamic somatostatinergic participation in the blunted GH release of obesity. J Clin Endocrinol Metab 68:290-293, 1989
42. Cordido F, Peñalva A, Dieguez C, et al: Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: Evidence for a marked somatotroph secretory capability in obesity. J Clin Endocrinol Metab 76:819-823, 1993
43. Bartness TJ, Polk DR, McGriff WR, et al: Reversal of high-fat diet-induced obesity in female rats. Am J Physiol 263:R790-R797, 1992
44. Gregory JW, Greene SA, Jung RT, et al: Changes in body composition and energy expenditure after six weeks' growth hormone treatment. Arch Dis Child 66:598-602, 1991
45. Cheema SK, Venkatraman J, Clandinin MT: Insulin binding to liver nuclei from lean and obese mice is altered by dietary fat. Biochim Biophys Acta 1117:37-41, 1992
46. Yamashita S, Melmed S: Effects of insulin on rat anterior pituitary cells. Inhibition of growth hormone secretion and mRNA levels. Diabetes 35:440-447, 1986