Not nonsense but antisense - Applications of antisense oligonucleotides in different fields of medicine

Wiener Klinische Wochenschrift

Volumn 109, Issue 2, 1997, Pages 40-46

  Oberbauer, Rainer ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

antisense; DNA; gene therapy; oligonucleotide; review

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE;

CANCER; CARDIOVASCULAR DISEASE; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE TARGETING; GENE THERAPY; HUMAN; MEDICAL RESEARCH; REVIEW; TRANSCRIPTION REGULATION; VIRUS INFECTION;

ANIMALS; CARDIOVASCULAR DISEASES; GENE THERAPY; HUMANS; NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; VIRUS DISEASES;

EID: 0031055810     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. Gamper M, Ganter B, Polito MR, Haas D (1992) RNA processing modulates the expression of the arcDABC operon in Pseudomonas aeruginosa. J Mol Biol 226: 943-957
2. Maher LJ 3rd (1996) Prospects for the therapeutic use of antigene oligonucleotides. Cancer Invest 14: 66-82
3. Wagner RW (1994) Gene inhibition using antisense oligodeoxynucleotides. Nature 372: 333-335
4. Srinivasan SK, Iversen P (1995) Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides. J Clin Lab Anal 9: 129-137
5. Zon G (1995) Antisense phosphorothioate oligodeoxynucleotides: introductory concepts and possible molecular mechanisms of toxicity. Toxicol Lett 83: 419-424
6. Albert PR, Morris SJ (1994) Antisense knockouts: molecular scalpels for the dissection of signal transduction. Trends Pharmacol Sci 15: 250-254
7. Zeng G, Ariga T, Gu XB, Yu RK (1995) Regulation of glycolipid synthesis in HL-60 cells by antisense oligonucleotidesto glycosyltransferase sequences: effect on cellular differentiation. Proc Natl Acad Sci USA 92: 8670-8674
8. Lipp P, Schwaller B, Niggli E (1995) Specific inhibition of Na-Ca exchange function by antisense oligonucleotides. FEBS Lett 364: 198-202
9. Oberbauer R, Schreiner GF, Biber J, Murer H, Meyer TW (1996) In vivo suppression of the renal Na+/Pi cotransporter by antisense oligonucleotides. Proc Natl Acad Sci USA 93: 4903-4906
10. Oberbauer R, Schreiner GF, Meyer TW (1995) Renal uptake of an 18-mer phosphorothioate oligonucleotide. Kidney Int 48: 1226-1232
11. Lefebvre d'Hellencourt C, Diaw L, Guenounou M (1995) Immunomodulation by cytokine antisense oligonucleotides. Eur Cytokine Netw 6: 7-19
12. Gershlick A, Brack MJ, More RS, Syndercombe-Court D, Balcon R (1993) Angiographic restenosis after angioplasty: comparison of definitions and correlation with clinical outcome. Coron Artery Dis 4: 73-81
13. Kahn JK, Rutherford BD, McConahay DR, Johnson WL, Giorgi LV, Hartzler GO (1990) Short- and long-term outcome of percutaneous transluminal coronary angioplasty in chronic dialysis patients. Am Heart J 119: 484-489
14. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Zhang L, Kaneda Y, Ogihara T, Dzau VJ (1993) Single intraluminal delivery of antisense cdc-2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci USA 90: 8474-8478
15. Simons M, Edelman ER, DeKeyser JL, Langer R, Rosenberg RD (1992) Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature 359: 67-70
16. Villa AE, Guzman LA, Poptic EJ, Labhasetwar V, D'Souza S (1995) Effects of antisense c-myc oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ Res 76: 505-513
17. Autieri MV, Yue TL, Ferstein GZ, Ohlstein E (1995) Antisense oligonucleotides to the p65 subunit of NF-kB inhibit human vascular smooth muscle cell adherence and proliferation and prevebt neointima formation in rat carotid arteries. Biochem Biophys Res Commun 24: 827-836
18. Bennett MR, Anglin S, McEwan JR, Jagoe R, Newby AC, Evan GI (1994) Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligonucleotides. J Clin Invest 93: 820-828
19. Biro S, Fu YM, Yu ZX, Epstein SE (1993) Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration. Proc Natl Acad Sci USA 90: 654-658
20. Bennett MR, Schwartz SM (1995) Antisense therapy for angioplasty restenosis. Some critical considerations. Circulation 92: 1981-1993
21. Stepkowski SM, Tu Y, Condon TP, Bennett CF (1994) Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities. J Immunol 153: 5336-5346
22. Wahlestedt C, Golanov E, Yamamoto S, Yee F, Ericson H, Yoo H, Inturrisi CE, Reis DJ (1993) Antisense oligonucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature 363: 260-263
23. Nesterova M, Cho-Chung YS (1995) A single-injection protein kinase A-directed antisense treatment to inhibit tumor growth. Nature Med 1: 528-533
24. Narayanan R (1994) Antisense therapy of cancer. In vitro 8: 787-793
25. Yung WK (1994) New approaches to molecular therapy of brain cancers. Curr Opin Neurol: 501-505
26. Whitesell L, Rosolen A, Neckers LM (1991) In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide. Antisense Rev Dev 1: 343-350
27. Skorski T, Nieborowska-Skorska M, Nicolaides NC, Szczylik C, Iversen P, Iozzo RV, et al. (1994) Suppression of Philadelphial leukemia cell growth in mice by bcr-abl antisense oligonucleotide. Proc Natl Acad Sci USA 91: 4504-4508
28. De-Lord C, Clutterbuck RD, Powles RL, Min T, Titley JC, Millar JL (1993) Human Philadelphia chromosome-positive chronic myeloid leukemia: a potential model for antisense therapy. Exp Hematol 21: 826-828
29. Dewanjee MK, Ghafouripour AK, Kapadvanjwala M, Dewanjee S, Serafini AN, Lopez DM, et al. (1994) Noninvasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model. J Nucl Med 35: 1054-1063
30. Whitton JL (1994) Antisense treatment of viral infection. Adv Virus Res 44: 267-303
31. Fenster SD, Wagner RW, Froehler BC, Chin DJ (1994) Inhibition of human immunodeficiency virus type-1 env expression by C-5 propyne oligonucleotides specific for rev-response element stem-loop V. Biochemistry 33: 8391-8393
32. Gao WY, Hanes RN, Vazquez-Padua MA, Stein CA, Cohen JS, Cheng YC (1990) Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides. Antimicrob Agents Chemother 34: 808-812
33. Moriya K, Matsukura M, Kurokawa K, Koike K (1996) In vivo inhibition of hepatitis B virus gene expression by antisense phosphorothioate oligonucleotides. Biochem Biophys Res Commun 218: 217-223
34. Shan YF, Gao HY, Ji H, Qiu MS, Wang DB (1994) Antiviral effects on mouse leukemia virus replication by oligodeoxynucleotides in vitro and in vivo. Chin Med J Engl 107: 146-150