Process development for the production of the (S)-acid precursor of a novel elastase inhibitor (L-694,458) through the lipase-catalyzed kinetic resolution of a β-lactam benzyl ester

Journal of Fermentation and Bioengineering

Volumn 83, Issue 1, 1997, Pages 48-53

  Roberge, Christopher ^a   Cvetovich, Raymond J ^a   Amato, Joseph S ^a   Pecore, Victor ^a   Hartner, Frederick W ^a   Greasham, Randolph ^a   Chartrain, Michel ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

biocatalysis; bioconversion; bioresolution; L 694,458; lipase; lactam

Indexed keywords

BIOCONVERSION; BIOSYNTHESIS; ENZYME KINETICS; ESTERS; SURFACE ACTIVE AGENTS;

BIORESOLUTION; ELASTASE; ENANTIOMERIC EXCESS; LACTAM;

ENZYME INHIBITION;

BENZYL ALCOHOL; BETA LACTAM DERIVATIVE; DPM 777; ELASTASE INHIBITOR; N [1 (1,3 BENZODIOXOL 5 YL)BUTYL] 3,3 DIETHYL 2 [4 [(4 METHYL 1 PIPERAZINYL)CARBONYL]PHENOXY] 4 OXO 1 AZETIDINECARBOXAMIDE; TRIACYLGLYCEROL LIPASE; TRITON X 100; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CATALYST; CHIRALITY; CONTROLLED STUDY; DRUG SYNTHESIS; ENANTIOMER; ENZYME MECHANISM; HYDROLYSIS; NONHUMAN; PRECURSOR; PURIFICATION; RACEMIC MIXTURE;

EID: 0031054955     PISSN: 0922338X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0922-338X(97)87326-6     Document Type: Article

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