Elevated levels of NO in both unchallenged and LPS-challenged C. parvum-primed mice are attributable to the activity of a cytokine-inducible isoforms of iNOS

Journal of Leukocyte Biology

Volumn 61, Issue 1, 1997, Pages 24-32

  Smith, Sidney R ^a   Manfra, Denise ^a   Davies, Liza ^a   Terminelli, Carol ^a   Denhardt, Georgetta ^a   Donkin, Jennifer ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

inhibitors; interleukin 10; lipopolysaccharide; nitric oxide synthase

Indexed keywords

AMINOGUANIDINE; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECOMBINANT INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES;

EID: 0031054849     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.61.1.24     Document Type: Article

References (25)

1. Vladutiu, A. O. (1995) Role of nitric oxide in autoimmunity. Clin. lmmunol. Immunopathol. 76, 1-11.
2. Mayhan, W. G. (1992) Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5′-diphosphate and bradykinin. Inflamm. 16, 295-305.
3. Marcinkewicz, J., Crabowska, A., Chain, B. (1995) Nitric oxide upregulates the release of inflammatory mediators by mouse macrophages. Eur. J. lmmunol. 25, 947-951.
4. G-monomethyl-L-arginine: A role for cyclic GMP. Blood 74, 1885-1887.
5. Evans, T., Carpenter, A., Kinderman, H., Cohen, J. (1993) Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ. Shock 41, 77-81.
6. Morris, S. M., Jr., Billiar, T. M. (1994) New insights into the regulation of inducible nitric oxide synthesis. Am. J. Physiol. 266, E829-E839.
7. Curran, R. D., Billiar, T. R., Steuhr, D. J., Ochoa, J. B., Harbrecht, B. G., Flint, S. G., Simmons, R. L. (1990) Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann. Surg. 212, 462-471.
8. Deng, W., Thiel, B., Tannenbaum, C. S., Hamilton, T. A., Steuhr, D. J. (1993) Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages. J. Immunol. 151, 322-329.
9. Griscavage, J. M., Rogers, N. E., Sherman, M. P., Ignarro, L. J. (1993) Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide, j. lmmunol. 151, 6329-6337.
10. Sheffler, L. A., Wink, D. A., Melillo, G., Cox, G. W. (1995) Exogenous nitric oxide regulates IFN-γ plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages. J. lmmunol. 155, 886-894.
11. Liu, S., Adcock, I. M., Old, R. W., Barnes, P. J., Evans, T. W. (1993) Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA. Biochem. Biophys. Res. Commun. 196, 1208-1213.
12. Sato, K., Miyakawa, K., Takeya, M., Hattori, R., Yui, Y., Sunamoto, M., Ichimori, Y., Ushio, Y., Takahashi, K. (1995) Immunohistochemical expression of inducible nitric oxide synthase (iNOS) in reversible endotoxic shock studied by a novel monoclonal antibody against rat iNOS. J. Leukcoc. Biol. 57, 36-44.
13. Wright, C. E., Rees, D. D., Moncada, S. (1992) Protective and pathological roles of nitric oxide in endotoxic shock. Cardiovasc. Res. 26, 48-57.
14. G-monomethyl-L-arginine inhibits endotoxin-induced nitrite/nitrate biosynthesis while promoting hepatic damage. J. leukoc. Biol. 48, 568-569.
15. Luss, H., DiSilvio, M., Litton, A. L., Vedia, L. M., Nussler, A. K., Billiar, T.R. (1994) Inhibition of nitric oxide synthesis enhances the expression of inducible nitric oxide synthase mRNA and protein in a model of chronic liver inflammation. Biochem. Biophys. Res. Commun. 204, 635-640.
16. Evans, T., Carpenter, A., Silva, A., Cohen, J. (1992) Differential effects of monoclonal antibodies to tumor necrosis factor alpha and gamma Interferon on induction of hepatic nitric oxide synthase in experimental gramnegative sepsis. Infect. Immun. 60, 4133-4139.
17. Evans, T. J., Strivens, E., Carpenter, A., Cohen, J. (1993) Differences in cytokine response and induction of nitric oxide synthase in endotoxinresistant and endotoxin-sensitive mice after intravenous gram-negative infection. J. Immunol 150, 5033-5040.
18. Schmidi, H. H. H. W., Wilke, P., Evers, B., Bohme, E. (1989) Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol. Biochem. Biophys. Res. Commun. 165, 284-291.
19. 15N] nitrate in biological fluids. Anal. Biochem. 126, 131-138.
20. Cunha, F. Q., Moncada, S., Liew, F. Y. (1992) Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in mouse macrophages. Biochem. Biophys. Res. Commun. 182, 1155-1159.
21. Cenci, E., Romani, L., Menacacci, A., Spaccapelo, R., Schiafella, E., Pucetti, P., Bestoni, F. (1993) Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur. J. Immunol. 23, 1034-1038.
22. Romani, L., Pucetti, P., Menacacci, A., Cenci, E., Spaccapelo, R., Tonnetti, L., Grobmann, U., Bestoni, F. (1994) Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J. Immunol. 152, 3514-3521.
23. Geller, D. A., DiSilvio, M., Nussler, A. K., Wang, S. C., Shapiro, R. A., Simmons, R. L., Billiar, T. R. (1993) Nitric oxide synthase expression is induced in hepatocytes in vivo during hepatic inflammation. J. Surg. Res. 55, 427-432.
24. Smith, S. R., Calzetta, A., Bankowski, J., Kenworthy-Bott, L., Terminelli, C. (1993) Lipopolysaccharide-induced cytokine production and mortality in mice treated with Corynebacterium parvum. J. Leukoc. Biol. 54, 23-29.
25. Laubach, V. E., Shesely, E. G., Smithies, O., Sherman, P. A. (1995) Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc. Natl. Acad. Sci. USA 92, 10688-10692.