The comparative efficacy of benzoyl peroxide 5%/erythromycin 3% gel and erythromycin 4%/zinc 1.2% solution in the treatment of acne vulgaris

British Journal of Dermatology

Volumn 136, Issue 2, 1997, Pages 235-238

  Chu, A ^a   Huber, F J ^b   Todd Plott, R ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b Dermik Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYL PEROXIDE; ERYTHROMYCIN; ZINC;

ACNE VULGARIS; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRY SKIN; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SKIN IRRITATION; TOPICAL DRUG ADMINISTRATION;

EID: 0031054704     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.1997.tb14903.x     Document Type: Article

References (18)

1. Kligman A, Leyden JJ, Stewart R. New use for benzoyl peroxide: a broad spectrum antimicrobial agent. Int J Dermatol 1977; 16: 413-17.
2. Chalker DK, Shalita A, Smith JG, Swann RW. A double-blind study of the effectiveness of a 3% erythromycin and 5% benzoyl peroxide combination in the treatment of acne vulgaris. J Am Acad Dermatol 1983; 9: 933-6.
3. Leyden JJ, Shalita A. Rational therapy for acne vulgaris: an update on topical treatment. J Am Acad Dermatol 1986; 15: 907-14.
4. Holland KT, Bojar RA, Cunliffe WJ et al. The effect of zinc and erythromycin on the growth of erythromycin-resistant and erythromycin sensitive isolates of Propionibacterium acnes: an in-vitro study. Br J Dermatol 1992; 126: 505-9.
5. Leyden JJ. An assessment of cumulative irritation associated with a combination of topical erythromycin and benzoyl peroxide. Cutis 1992; 49: 20-2.
6. Pierard GE, Pierard-Franchimont C. Effect of topical erythromycin-zinc formulation on sebum delivery. Evaluation by combined photometric-multi-step samplings with Sebutape. Clin Exp Dermatol 1993; 18: 410-13.
7. Van Hoogdalem EJ, Terpstra JJ, Baven ALM. Evaluation of the effect of zinc acetate on the stratum corneum penetration kinetics of erythromycin in healthy male volunteers. Skin Pharmacol 1996: 104-10.
8. Shalita AR, Chalker DK, Ellis CN et al. A multicenter, double-blind, controlled study of the combination of erythromycin/benzoyl peroxide, erythromycin alone and benzoyl peroxide alone in the treatment of acne vulgaris. Cutis 1992; 49: 1-4.
9. Leyden JJ. Open-label evaluation of topical antimicrobial and antiacne preparations for effectiveness versus Propionibacterium acnes in vivo. Cutis 1992; 49: 8-11.
10. Eady EA, Farmery MR, Ross JI et al. Effects of benzoyl peroxide and erythromycin alone in combination against antibiotic-sensitive and resistant skin bacteria from acne patients. Br J Dermatol 1994; 31: 331-6.
11. Eady EA, Bojar RA, Jones CE et al. The effects of acne treatment with a combination benzoyl peroxide and erythromycin on skin carriage of erythromycin resistant propionibacteria. Br J Dermatol 1996; 134: 107-13.
12. Harkaway KS, McGinley KJ, Foglia AN et al. Antibiotic resistance patterns in coagulase-negative staphylococci after treatment with topical erythromycin, benzoyl peroxide and the combination therapy. Br J Dermatol 1992; 126: 586-90.
13. Cunliffe WJ. Drug resistant propionibacteria: the beginning of the end of antibiotic therapy for acne? Oral presentation, European Academy of Dermatology and Venereology Meeting, October 12, 1995, Brussels, Belgium.
14. Leyden JJ, McGinley KJ, Cavalieri S et al. Propionibacterium acnes resistance to antibiotics in acne patients. J Am Acad Dermatol 1983; 8: 41-5.
15. Eady EA, Cove JH, Holland KT, Cunliffe WJ. Erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure. Br J Dermatol 1989; 121: 51-7.
16. Tucker SB, Townsend R, Cochran R, Flannigan SA. Comparison of topical clindamycin phosphate, benzoyl peroxide and a combination of the two for the treatment of acne vulgaris. Br J Dermatol 1984; 110: 487-92.
17. Cochran RJ, Tucker SB, Flannigan SA. Topical zinc therapy for acne vulgaris. Int J Dermatol 1985; 24: 188-90.
18. Bojar RA, Eady EA, Jones CE et al. Inhibition of erythromycin-resistant propionibacteria on the skin of acne patients by topical erythromycin with and without zinc. Br J Dermatol 1994; 130: 329-36.