Induction of AIDS by simian immunodeficiency virus lacking NF-κB and SP1 binding elements

Journal of Virology

Volumn 71, Issue 3, 1997, Pages 1880-1887

  Ilyinskii, Petr O ^a   Simon, Meredith A ^a   Czajak, Susan C ^a   Lackner, Andrew A ^a   Desrosiers, Ronald C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEF PROTEIN; TRANSCRIPTION FACTOR SP1;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DELETION MUTANT; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; MOLECULAR CLONING; MONKEY DISEASE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROVIRUS; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0031054448     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.3.1880-1887.1997     Document Type: Article

References (28)

1. Clark, N. M., M. C. Hannibal, and D. M. Markovitz. 1995. The peri-κB site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells. J. Virol. 69:4854-4862.
2. Garcia, J. A., F. K. Wu, R. Mitsuyasu, and R. B. Gaynor. 1987. Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus. EMBO J. 6:3761-3770.
3. Gibbs, J. S., A. A. Lackner, S. M. Lang, M. A. Simon, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1995. Progression to AIDS in the absence of a gene for vpr or vpx. J. Virol. 69:2378-2383.
4. Guyader, M., M. Emerman, P. Sonigo, F. Clavel, L. Montagnier, and M. Alizon. 1987. Genome organization and transactivation of the human immunodeficiency virus type 2. Nature 236:662-669.
5. Hannibal, M. C., D. M. Markovitz, N. Clark, and G. J. Nabel. 1993. Differential activation of human immunodeficiency virus type 1 and 2 transcription by specific T-cell activation signals. J. Virol. 67:5035-5040.
6. Harrich, D., J. Garcia, F. Wu, R. Mitsuyasu, J. Gonzalez, and R. Gaynor. 1989. Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat. J. Virol. 63:2585-2591.
7. Hilfinger, J. M., N. Clark, M. Smith, K. Robinson, and D. M. Markovitz. 1993. Differential regulation of the human immunodeficiency virus type 2 enhancer in monocytes at various stages of differentiation. J. Virol. 67:4448-4453.
8. Ilyinskii, P. O., M. D. Daniel, M. A. Simon, A. A. Lackner, and R. C. Desrosiers. 1994. The role of upstream U3 sequences in the pathogenesis of simian immunodeficiency virus-induced AIDS in rhesus monkeys. J. Virol. 68:5933-5944.
9. Ilyinskii, P. O., and R. C. Desrosiers. 1996. Efficient transcription and replication of simian immunodeficiency virus in the absence of NF-κB and Sp1 binding elements. J. Virol. 70:3118-3126.
10. Jones, K. A., J. T. Kadonaga, P. A. Luciw, and R. Tjian. 1986. Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science 232:755-759.
11. Kawakami, K., C. Scheidereit, and R. G. Roeder. 1988. Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-κB) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro. Proc. Natl. Acad. Sci. USA 85:4700-4704.
12. Kestler, H., T. Kodama, D. Ringler, M. Marthas, N. Pedersen, A. Lackner, D. Regier, P. Sehgal, M. Daniel, N. King, and R. Desrosiers. 1990. Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science 248:1109-1112.
13. Kestler, H. W., III, D. J. Ringler, K. Mori, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651-662.
14. Leonard, J., C. Parrott, A. J. Buckler-White, W. Turner, E. K. Ross, M. A. Martin, and A. B. Rabson. 1989. The NF-κB binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity. J. Virol. 63:4919-4924.
15. Maciaszek, J. W., D. A. Talmage, and G. A. Viglianti. 1994. Synergistic activation of simian immunodeficiency virus and human immunodeficiency virus type 1 transcription by retinoic acid and phorbol ester through an NF-κB-independent mechanism. J. Virol. 68:6598-6604.
16. Markovitz, D. M., M. Hannibal, V. L. Perez, C. Gauntt, T. M. Folks, and G. J. Nabel. 1990. Differential regulation of human immunodeficiency viruses (HIVs): a specific regulatory element in HIV-2 responds to stimulation of the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 87:9099-9102.
17. Markovitz, D. M., M. J. Smith, J. Hilfinger, M. C. Hannibal, B. Petryniak, and G. J. Nabel. 1992. Activation of the human immunodeficiency virus type 2 enhancer is dependent on purine box and κB regulatory elements. J. Virol. 66:5479-5484.
18. Nabel, G., and D. Baltimore. 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711-712.
19. Naidu, Y. M., H. W. Kestler III, Y. Li, C. V. Butler, D. P. Silva, D. K. Schmidt, C. D. Troup, P. K. Sehgal, P. Sonigo, M. D. Daniel, and R. C. Desrosiers. 1988. Characterization of infectious molecular clones of simian immunodeficiency virus (SIVmac) and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly cloned SIVmac. J. Virol. 62:4691-4696.
20. Parrott, C., T. Seidner, E. Duh, J. Leonard, T. S. Theodore, A. Buckler-White, M. A. Martin, and A. B. Rabson. 1991. Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T lymphocytes. J. Virol. 65:1414-1419.
21. Perkins, N. D., N. L. Edwards, C. S. Duckett, A. B. Agranoff, R. M. Schmid, and G. J. Nabel. 1994. A cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation. EMBO J. 12:3551-3558.
22. Regier, D. A., and R. C. Desrosiers. 1990. The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus. AIDS Res. Hum. Retroviruses 6:1221-1231.
23. Renjifo, B., N. A. Speck, S. Winandy, N. Hopkins, and Y. Li. 1990. cis-Acting elements in the U3 region of a simian immunodeficiency virus. J. Virol. 64:3130-3134.
24. Rosen, C. A., J. G. Sodroski, and W. A. Haseltine. 1985. The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell 41:813-823.
25. Ross, E. K., A. J. Buckler-White, A. B. Rabson, G. Englund, and M. A. Martin. 1991. Contribution of NF-κB and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types. J. Virol. 65:4350-4358.
26. Simon, M. A., L. V. Chalifoux, and D. J. Ringler. 1992. Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution. AIDS Res. Hum. Retroviruses 8:327-337.
27. Winandy, S., B. Renjifo, Y. Li, and N. Hopkins. 1992. Nuclear factors that bind two regions important to transcriptional activity of the simian immunodeficiency virus long terminal repeat. J. Virol. 66:5216-5223.
28. Wykrzykowska, J. J., D. R. Pauley, A. A. Lackner, and M. A. Simon. 1996. Evaluation of anti-human antibodies for immunohistochemistry on archival nonhuman primate tissues. J. Med. Primatol. 25:71-77.