Drug receptor mechanisms in smooth muscle: β-chloroethylamine-sensitive and -resistant receptor mechanisms

Japanese Journal of Pharmacology

Volumn 73, Issue 1, 1997, Pages 1-22

  Takayanagi, Issei ^a   Koike, Katsuo ^a   Satoh, Mitsutoshi ^a   Okayasu, Ayako ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

Drug receptor mechanism; M3 Cholinoceptor; Signal transduction; 1 Adrenoceptor; Chloroethylamine

Indexed keywords

2 CHLOROETHYLAMINE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; BENZOYLCHOLINE; BUTYLTRIMETHYLAMMONIUM; BUTYRYLCHOLINE; CALCIUM; CALCIUM ION; CALMODULIN; CARBACHOL; CHLOROETHYLCLONIDINE; CHOLINE DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; HEPTYLTRIMETHYLAMMONIUM; HEXANOYLCHOLINE; HIMBACINE; MUSCARINIC M3 RECEPTOR; MYOSIN LIGHT CHAIN KINASE INHIBITOR; OTENZEPAD; PARTIAL AGONIST; PILOCARPINE; PIRENZEPINE; PROPIONYLCHOLINE IODIDE; PROPYLBENZILOYLCHOLINE MUSTARD; PROTEIN KINASE C; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL TISSUE; BINDING AFFINITY; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; DRUG RECEPTOR BINDING; GUINEA PIG; ILEUM; NONHUMAN; RABBIT; RECEPTOR AFFINITY; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; THORACIC AORTA;

EID: 0031053850     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.73.1     Document Type: Review

References (89)

1. Stephenson RP: A modification of receptor theory. Br J Pharmacol 11, 379-393 (1956)
2. Nickerson M: Receptor occupancy and tissue receptor. Nature 178,697-698 (1956)
3. Van Rossum JM and Ariëns E J : Receptor reserve and threshold-phenomena. II. Arch Int Pharmacodyn Ther 136, 385-413 (1962)
4. Hulme EC, Birdsall NJM and Buckley NJ: Muscarinic receptor subtype. Annu Rev Pharmacol Toxicol 30, 633-673 (1990)
5. Hisayama T, Kumagai N and Takayanagi I: Two apparently distinct muscarinic cholinoceptor mechanisms in guinea-pig taenia caecum. Jpn J Pharmacol 46, 414-417 (1988)
6. Takayanagi I, Hisayama T, Kiuchi Y and Sudo H: Propylbenzilylcholine mustard discriminates between two subtypes of muscarinic cholinoceptors in guinea-pig taenia caecum. Arch Int Pharmacodyn Ther 298, 210-219 (1989)
7. Young JM, Hiley R and Burgen ASV: Homologues of benzilylcholine mustard. J Pharm Pharmacol 24, 950-954 (1972)
8. Takayanagi I, Harada M and Koike K: A difference in receptor mechanisms for muscarinic full and partial agonist. Jpn J Pharmacol 56, 23-31 (1991)
9. Dörje F, Wess J, Lambrecht G, Tacke R, Mutschier E and Brann MR: Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 256, 727-733 (1991)
10. Caulfield MP: Muscarinic receptors: characterization, coupling and function. Pharmacol Ther 58, 319-379 (1993)
11. Friebe TP, Mutschier E and Lambrecht G: Muscarinic receptor subtype: pharmacological characterization, molecular structure, location, function and receptor-effector coupling. Pharm Ztg Wiss 138, 3-11 (1993)
12. Wess J: Molecular basis of muscarinic acetylcholine receptor function. Trends Pharmacol Sei 14, 308-313 (1993)
13. Hammer R, Berrie CP, Birdsall NJM, Burgen ASV and Hulme EC: Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature 283, 90-92 (1980)
14. Hammer R, Giraldo E, Schiavi GB, Monferini E and Ladinsky H: Binding profile of a novel cardioselective muscarinic receptor antagonist, AF-DX116, to membranes of peripheral tissues and brain in the rat. Life Sci 38, 1653-1662 (1986)
15. Anwar-ul S, Gilani H and Cobbin LB: The cardioselectivity of himbacine: a muscarine receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol 332, 16-20 (1986)
16. Barlow RB, Berry KJ, Glenton PAM, Nikolaou NM and Son KS: A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea pig atrial pacemaker cells at 29 °C and in ileum at 29°C and 37°C. Br J Pharmacol 58, 613-620 (1976)
17. Harada M, Koike K and Takayanagi I: Characterization of subtype of propylbenzilylcholine mustard (PrBCM)-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle. Jpn J Pharmacol 59, 485-487 (1992)
18. Takayanagi I, Koike K and Saito K: Propylbenzilylcholine mustard-sensitive and -resistant muscarinic receptors in cardiac muscle. Gen Pharmacol 22, 691-694 (1991)
19. Christophe J, De Neef P, Robberecht P and Waelbroeck M: Propylbenzilylcholine mustard is selective for rat heart muscarinic receptors having a low affinity for agonists. Br J Pharmacol 88, 63-70 (1986)
20. Fukuda K, Kubo T, Maeda A, Akiba I, Bujo H, Nakai J, Mishina M, Higashida H, Neher E, Marty A and Numa S: Selective effector coupling of muscarinic acetylcholine receptor subtypes. Trends Pharmacol Sci 10, Supp, 4-10 (1989)
21. Jakobs KH, Aktories K and Schultz G: GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists. Naunyn Schmiedebergs Arch Pharmacol 310, 113-119 (1979)
22. + and GTP. J Cyclic Nucleotide Res 5, 367-375 (1979)
23. Brown SL and Brown JH: Muscarinic stimulation of phosphatidylinositol metabolism in atria. Mol Pharmacol 24, 351-356 (1983)
24. Brown JH and Masters SB: Muscarinic regulation of phosphatidylinositol turnover and cyclic nucleotide metabolism in the heart. Fed Proc 43, 2613-2617 (1984)
25. Masters SB, Harden TK and Brown JH: Relationship between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells. Mol Pharmacol 26, 149-155 (1984)
26. Pfaffinger PJ, Martin JM, Hunter D, Nathans NM and Hille B: GTP-binding proteins couple cardiac muscarinic receptors to a K channel. Nature 317, 536-538 (1985)
27. Breitwieser GE and Szabo G: Uncoupling of cardiac muscarinic and α-adrenergic receptors from ion channels by a guanine nucleotide analogue. Nature 317, 538-540 (1985)
28. Peralta EG, Ashkenazi A, Winslow JW, Ramachandran J and Capon DJ: Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes. Nature 334, 434-437 (1988)
29. Kiuchi Y, Kumagai N, Hisayama T and Takayanagi I: Guanosine 5′-triphosphate converts some populations of propylbenzilylcholine mustard-sensitive muscarinic cholinoceptor sites to sites resistant to the drug in intestinal smooth muscle. Jpn J Pharmacol 55, 329-338 (1991)
30. Birdsall NJM, Burgen ASV and Hulme EC: The binding of agonists to brain muscarinic receptors. Mol Pharmacol 14, 723-736 (1978)
31. Ehlert FJ, Roeske WL and Yamamura HI: Muscarinic receptor: Regulation by guanine nucleotides, ion and N-ethylmaleimide. Fed Proc 40, 153-159 (1981)
32. Harden TK, Meeker RB and Martin MW: Interaction of a radiolabeled agonist with cardiac muscarinic cholinergic receptors. J Pharmacol Exp Ther 227, 570-577 (1983)
33. Uchida S, Matsumoto K, Mizushima A, Osugi T, Higuchi H and Yoshida H: Effects of guanine nucleotide and sulfhydryl reagent of subpopulations of muscarinic acetylcholine receptors in mammalian hearts: possible evidence for interconversion of super-high and low affinity agonist binding sites. Eur J Pharmacol 100, 291-298 (1984)
34. 2 receptors consist of two different types, both regulated by GTP. Eur J Pharmacol 135, 403-409 (1987)
35. Adachi S, Koike K and Takayanagi I: Pharmacological characteristics of indoline derivatives in muscarinic receptor subtypes. Pharmacology 53, 250-258 (1996)
36. 1-adrenergic receptors revealed by chloroethylclonidine. Mol Pharmacol 32, 505-510 (1987)
37. 2+ signalling mechanism and plays a different physiological role. Mol Pharmacol 38, 725-736 (1990)
38. 1-adrenoceptor mechanisms for phenylephrine and tizanidine in rabbit thoracic aorta and common iliac artery. Can J Physiol Pharmacol 69, 1819-1824 (1991)
39. 1-agonists, norepinephrine and clonidine, by selective antagonists of their subtypes in rabbit thoracic aorta. Jpn J Pharmacol 60, 169-177 (1992)
40. 1B-adrenoceptors in the presence of guanosine 5′-triphosphate in rabbit thoracic aorta. Jpn J Pharmacol 63, 1-8 (1993)
41. Ozaki H, Sato K, Satoh T and Karaki H: Simultaneous recordings of calcium signals and mechanical activity using fluorescent dye fura 2 in isolated strips of vascular smooth muscle. Jpn J Pharmacol 45, 429-433 (1987)
42. Sato K, Ozaki H and Karaki H: Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2. J Pharmacol Exp Ther 246, 294-300 (1988)
43. 2+ level. Naunyn Schmiedebergs Arch Pharmacol 341, 80-87 (1990)
44. 2+ localization and sensitivity in vascular smooth muscle. Trends Pharmacol Sei 10, 320-325 (1989)
45. Nishimura J, Khalil RA and van Breemen C: Agonist-induced vascular tone. Hypertension 13, 835-844 (1989)
46. Konno F and Takayanagi I: Relationship between the contractile responses and their coupling second messenger systems for muscarinic drugs in the guinea pig ileal longitudinal muscle. Arch Int Pharmacodyn Ther 301, 15-29 (1989)
47. 2+ concentration in isolated longitudinal muscle of guinea pig ileum. Jpn J Pharmacol 53, 525-528 (1990)
48. 2+ for contraction in guinea pig intestinal smooth muscle. Eur J Pharmacol 187, 139-142 (1990)
49. Takayanagi I, Ohtsuki H, Saito K, Koike K and Satoh M: Propylbenzilylcholine mustard (PrBCM)-sensitive cholinoceptors and contractile response to partial agonist in guinea pig ileal muscle. Jpn J Pharmacol 56, 151-158 (1991)
50. 2+ concentration in the presence of clonidine, an adrenergic partial agonist, than in the presence of norepinephrine. J Pharmacobiodyn 12, 781-786 (1989)
51. 2+ more effectively for contraction in aortic smooth muscle. Can J Physiol Pharmacol 68, 1329-1333 (1990)
52. Adelstein RS and Eisenberg E: Regulation and kinetics of the actin-myosin-ATP interaction. Annu Rev Biochem 49, 921-956 (1980)
53. Chatterjee M and Tejada M: Phorbol ester-induced contraction in chemically skinned vascular smooth muscle. Am J Physiol 251, C356-C361 (1986)
54. 3 of Clostridium botulinum. Mol Cell Biol 8, 418-426 (1988)
55. Kitazawa T, Kobayashi S, Horiuchi K, Somlyo AV and Somlyo AP: Receptor-coupled, permeabilized smooth muscle. J Biol Chem 264, 5339-5342 (1989)
56. Hirata K, Kikuchi A, Sasaki T, Kuroda S, Kaibuchi K, Matsuura Y, Seki H, Saida K and Takai Y: Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem 267, 8719-8722 (1992)
57. Lee MW and Severson DL: Signal transduction in vascular smooth muscle: diacylglycerol second messengers and PKC action. Am J Physiol 267, C659-C678 (1994)
58. Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase. Science 258, 607-614 (1992)
59. Pears CJ and Parker PJ: Domain interactions of protein kinase C. J Cell Sci 100, 683-686 (1991)
60. i. Am J Physiol 262, H754-H762 (1992)
61. 2+-sensitivity in a-toxin-permeabilized rabbit mesenteric artery. Circ Res 71, 951-959 (1992)
62. 2+-sensitization in rabbit thoracic aorta. Eur J Pharmacol 265, 133-139 (1994)
63. Park S and Rasmussen H: Carbachol-induced protein phos- phorylation changes in bovine tracheal smooth muscle. J Biol Chem 261, 15734-15739 (1986)
64. Blakeley AG, Brown DA, Cunnane TC, French AM, McGrath JC and Scott NC: Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens. Nature 294, 759-761 (1981)
65. Colburn JC, Michnoff CH, Hsu LC, Slaughter CA, Kamm KE and Stull JT: Sites phosphorylated in myosin light chain in contracting smooth muscle. J Biol Chem 263, 19166-19173 (1988)
66. Nishiye E, Somlyo AV, Török K and Somlyo AP: The effects of MgADP on cross-bridge kinetics: A laser flash photolysis study of guinea-pig smooth muscle. J Physiol (Lond) 460, 247-271 (1993)
67. 2+-sensitization. Eur J Pharmacol 290, 19-27 (1995)
68. Hori M, Sato K, Sakata K, Ozaki H, Takano-Ohmuro H, Tsuchiya T, Sugi H, Kato I and Karaki H: Receptor agonists induce myosin phosphorylation-dependent and phosphorylation-independent contractions in vascular smooth muscle. J Pharmacol Exp Ther 261, 506-512 (1992)
69. Ohanian V, Ohanian J, Shaw L, Scarth S, Parker PJ and Heagerty AM: Identification of protein kinase C isoforms in rat mesenteric small arteries and their possible role in agonistinduced contraction. Circ Res 78, 806-812 (1996)
70. Morii N, Sekine A, Ohashi Y, Nakao K, Imura H, Fujiwara M and Narumiya S: Purification and properties of the cytosolic substrate for botulinum ADP-ribosyltransferase. J Biol Chem 263, 12420-12426 (1988)
71. Hall A: The cellular functions of small GTP-binding protein. Science 249, 635-640 (1990)
72. Narumiya S, Sekine A and Fujiwara M: Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product. J Biol Chem 263, 17255-17257 (1988)
73. 3. Biochem Biophys Res Commun 158, 209-213 (1989)
74. 3 from porcine brain cytosol and its characterization as a GTP-binding protein highly homologous to the rho gene product. FEBS Lett 243, 70-76 (1989)
75. Sekine A, Fujiwara M and Narumiya S: Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. J Biol Chem 264, 8602-8605 (1989)
76. Kitazawa T, Masuo M and Somlyo AP: G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle, Proc Natl Acad Sei USA 88, 9307-9310 (1991)
77. 2+-sensitivity for contraction in rabbit thoracic aorta. Gen Pharmacol 26, 357-362 (1995)
78. Clark T, Ngai PK, Sutherland C, Gröschel-Stewart U and Walsh MP: Vascular smooth muscle caldesmon. J Biol Chem 261, 8028-8035 (1986)
79. Abe M, Takahashi T and Hiwada K: Simplified co-purification of vascular smooth muscle calponin and caldesmon. J Biochem 107, 507-509 (1990)
80. Abe M, Takahashi T and Hiwada K: Effect of calponin on actin-activated myosin ATPase activity. J Biochem 108, 835-838 (1990)
81. Takayanagi I: Pharmacological studies on drug receptor mechanisms. Yakugaku Zasshi 116, 417-440 (1996) (Abstract, figures and tables in English)
82. Nishimura J and van Breemen C: Direct regulation of smooth muscle contractile elements by second messengers. Biochem Biophys Res Commun 163, 929-935 (1989)
83. Anabuki J, Hori M, Ozaki H, Kato I and Karaki H: Mechanisms of pinacidil-induced vasodilation. Eur J Pharmacol 190, 373-379 (1990)
84. Singer HA: Phorbol ester-induced stress and myosin light chain phosphorylation in swine carotid medial smooth muscle. J Pharmacol Exp Ther 252, 1068-1074 (1990)
85. 2+ sensitivity in β-escin skinned smooth muscle. Jpn J Pharmacol 67, 1-7 (1995)
86. Koike K and Takayanagi I: A possible mechanism in interaction of a partial agonist with β-adrenoceptor in guinea-pig taenia caecum: Effects of Gpp(NH)p on its two different binding sites. Jpn J Pharmacol 38, 169-176 (1985)
87. Koike K and Takayanagi I: A beta-adrenergic partial agonist (befunolol) discriminates two different affinity sites. Jpn J Pharmacol 42, 325-328 (1986)
88. Takayanagi I, Koike K and Nakagoshi A: Beta-adrenergic partial agonists and two different affinity sites in beta-adrenoceptor. In Recent Research on Neurotransmitter Receptors, Edited by Yoshida H, pp 41-52, Excerpta Medica, Amsterdam (1986)
89. Takayanagi I, Koike K and Nakagoshi A: Interactions of some partial agonists with high and low affinity binding sites in β-adrenoceptors. Can J Physiol Pharmacol 65, 18-22 (1987)