Prevalence of increased intracellular signal transduction in immortalized lymphoblasts from patients with essential hypertension and normotensive subjects

Journal of Hypertension

Volumn 15, Issue 1, 1997, Pages 29-33

  Gruska, Sybille ^a   Ihrke, Roland ^a   Stolper, Sören ^a   Kraatz, Günter ^a   Siffert, Winfried ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Calcium; G protein; Platelet activating factor; Sodium proton exchange

Indexed keywords

CALCIUM ION; FURA 2; THROMBOCYTE ACTIVATING FACTOR;

ADULT; AGED; ARTICLE; B LYMPHOBLAST; CALCIUM CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0031053573     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199715010-00003     Document Type: Article

References (9)

1. Siffert W, Düsing R: Sodium-proton exchange and primary hypertension - an update. Hypertension 1995, 26:649-655.
2. Rosskopf D, Frömter E, Siffert W: Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients - a cell culture model for human hypertension. J Clin Invest 1993, 92:2553-2559.
3. Rosskopf D, Härtung K, Hense J, Siffert W: Enhanced immunoglobulin formation of immortalized B cells from hypertensive patients. Hypertension 1995, 26:432-435.
4. + antiporter phenotype, abundance, and phosphorylation of immortalized lymphoblasts from humans with hypertension. Hypertension 1995, 25:971-977.
5. Siffert W, Rosskopf D, Moritz A, Wieland T, Kaldenberg-Stasch S, Kettler N, et al.: Enhanced Q protein activation in immortalized lymphoblasts from patients with essential hypertension. J Clin Invest 1995, 96:759-766.
6. Mazer BD, Sawami H, Tordai A, Gelfand EW: Platelet-activating factor-mediated transmembrane signaling in human B lymphocytes is regulated through a pertussis- and cholera toxin-sensitive pathway. J Clin Invest 1992, 90:759-765.
7. Wieland T, Liedel K, Kaldenberg-Stasch S, Meyer zu Heringdorf D, Schmidt M, Jakobs KH: Analysis of receptor-G protein interactions in permeabilized cells. Naunyn Schmiedebergs Arch Pharmacol 1995, 351:329-336.
8. Canessa M, Morgan K, Goldszer R, Moore TJ, Spalvins A: Kinetic abnormalities of the red blood cell sodium-proton exchange in hypertensive patients. Hypertension 1991, 17:340-348.
9. Busch S, Burckhardt B-C, Siffert W: Expression of the human sodium-proton exchanger NHE-1 in Xenopus laevis oocytes enhances sodium-proton exchange activity and establishes sodium-lithium countertransport. Pfülgers Arch 1995, 429:859-869.