Effect of lipid and propofol on oxidation of haemaglobin by reactive oxygen species

British Journal of Anaesthesia

Volumn 78, Issue 3, 1997, Pages 320-322

  Stratford, N ^a   Murphy, P ^b  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

Anaesthetics i.v., propofol; Blood, haemoglobin; Formulations, propofol; Metabolism, lipids

Indexed keywords

HEMOGLOBIN; HYPOXANTHINE; INTRAVENOUS ANESTHETIC AGENT; LIPID; PROPOFOL; REACTIVE OXYGEN METABOLITE; XANTHINE OXIDASE;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; HUMAN; LIPID PEROXIDATION; OXIDATION; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

EID: 0031053175     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/78.3.320     Document Type: Article

References (6)

1. Murphy PG, Bennett JR, Myers DS, Davies MJ, Jones JG. The effect of propofol on free radical-induced lipid peroxidation in rat liver microsomes. European Journal of Anesthesiology 1993; 10: 261-266.
2. Aarts L, van der Hee R, Dekker I, de Jong J, Langemeijer H, Bast A. The widely used anesthetic agent propofol can replace α-tocopherol as an antioxidant. FEBS Letters 1995; 357: 83-85.
3. Murphy PG, Davies MJ, Columb MO, Stratford N. Effect of propofol and thiopentone on free radical mediated oxidative stress of the erythrocyte. British Journal of Anaesthesia 1996; 76: 536-543.
4. Giulivi C, Davies KJA. A novel antioxidant role for hemoglobin. Journal of Biological Chemistry 1990; 265: 19453-19460.
5. Murphy PG, Myers DS, Davies MJ, Webster NR, Jones JG. The antioxidant potential of propofol (2, 6-diisopropylphenol). British Journal of Anaesthesia 1992; 68: 613-618.
6. Musacchio E, Rizzli V, Bianchi M, Bindola A, Galzigna L. Antioxidant action of propofol on liver microsomes, mitochondria and brain synaptosomes in the rat. Pharmacology and Toxicology 1991; 69: 75-77.