A DNA polymerase or accessory protein exhibits structural and functional similarities to SV40 large tumor antigen

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 374, Issue 1, 1997, Pages 109-123

  Crouch, Elizabeth ^a   Miller, Susan ^a   Wilson, Van ^b   Busbee, David ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

DNA polymerase ; DNA polymerase accessory protein; DNA synthesis; SV40 T antigen

Indexed keywords

DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE ALPHA; HELICASE; RETINOBLASTOMA PROTEIN; VIRUS LARGE T ANTIGEN; DNA PRIMASE; RNA POLYMERASE; VIRUS T ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BACULOVIRUS; CELL CYCLE; CELL LINE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; INSECT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANIMAL; ARMYWORM; CELL CULTURE; CHEMISTRY; DNA REPLICATION; MOUSE; SIMIAN VIRUS 40; WESTERN BLOTTING;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BLOTTING, WESTERN; CELL LINE; DNA PRIMASE; DNA REPLICATION; MICE; RNA NUCLEOTIDYLTRANSFERASES; SIMIAN VIRUS 40; SPODOPTERA; TUMOR CELLS, CULTURED;

EID: 0031052725     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00231-X     Document Type: Article

References (37)

1. Goulian, M., Heard, C.J. and Grimm, S.L. (1990) Purification and properties of an accessory protein for DNA polymerase α/primase. J. Biol. Chem., 265(22), 13221-13230.
2. Goulian, M. and Heard, C.J. (1990) The mechanism of action of an accessory protein for DNA polymerase α/primase. J. Biol. Chem., 265(22), 13231-13239.
3. Busbee, D., Miller, S., Schroeder, M., Srivastava, V., Guntapalli, B., Merriam, E., Holt, S., Wilson, V. and Hart, R. (1995) DNA polymerase alpha function and fidelity: Dietary restriction as it affects age-related enzyme changes, in: R.W. Hart, D.A. Neuman and R.T. Robertson (Eds.), Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies, ILSI Press, Washington, DC.
4. Schroeder, M., Srivastava, V., Miller, S., Merriam, E., Holt, S., Wilson, V. and Busbee, D. (1996) An accessory protein enhances both DNA binding and activity of DNA polymerase α isolated from normal, but not transformed, human fibroblasts. Mutation Res., 316, 237-248.
5. Tsurimoto, T. and Stillman, B. (1991) Switching of DNA polymerase alpha and delta during initiation of leading and lagging strand synthesis, J. Biol. Chem., 266, 1961-1968.
6. Collins, K. and Kelly, T. (1991) Effects of T-antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase alpha-primase. Mol. Cell. Biol., 11, 2108-2115.
7. Waga, S., Bauer, G. and Stillman, B. (1994) Reconstitution of complete SV40 DNA replication with purified replication factors. J. Biol. Chem., 269, 10923-10934.
8. Erdile, L.F., Collins, K.L., Russo, A., Simancek, P., Small, D., Umbricht, C., Virshup, D., Cheng, L., Randall, S., Weinberg, D., Moarefi, I., Fanning, E. and Kelly, T. (1991) Initiation of SV40 DNA Replication: Mechanism and Control. Cold Spring Harbor Symp. Quant. Biol., 56, 303-313.
9. Wiekowski, M., Schwartz, M.W. and Stahl, H. (1988) Simian virus 40 large T antigen DNA helicase: characterization of the ATPase-dependent DNA unwinding activity and its substrate requirements. J. Biol. Chem., 263, 436-442.
10. McVey, D., Ray, S., Gluzman, Y., Berger, L., Wildeman, A.G., Marshak, D.R. and Tegtmeyer, P. (1993) cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen. J. Virol., 67, 5206-5215.
11. Dornreiter, I., Copeland, W.C. and Wang, T.S.-F. (1993) Initiation of Simian virus 40 DNA replication requires the interaction of a specific domain of human DNA polymerase α with large T antigen. Mol. Cell. Biol., 13, 809-820.
12. Moses, K. and Prives, C. (1994) A unique subpopulation of murine DNA polymerase alpha/primase specifically interacts with polyomavirus T antigen and stimulates DNA replication. Mol. Cell. Biol., 14, 2767-2776.
13. Dornreiter, I., Höss, A., Arthur, A.K. and Fanning, E. (1990) SV40 T antigen binds directly to the large subunit of purified DNA polymerase alpha. EMBO J., 9, 3329-3336.
14. Dornreiter, I., Erdile, L.F., Gilbert, I.U., von Winkler, D., Kelly, T.J. and Fanning, E. (1992) Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen. EMBO J., 11, 769-776.
15. Matsumoto, T., Toshihiko, E. and Hurwitz, J. (1990) Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system. Proc. Natl. Acad. Sci. USA, 87, 9712-9716.
16. Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W. (Eds.) (1991) Current Protocols in Immunology, Green Publishing Associates, Inc., New York.
17. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K. (Eds.) (1989) Current Protocols in Molecular Biology, Green Publishing Associates and Wiley Interscience, New York.
18. Höss, A., Moarefi, I., Scheidtmann, K.-H., Cisek, L.J., Corden, J.L., Dornreiter, I., Arthur, A.K. and Fanning, E. (1990) Altered phosphorylation pattern of simian virus 40 T antigen expressed in insect cells by using a baculovirus vector. J. Virol., 64, 4799-4807.
19. Wang, N.P., Chen, P.-L., Huang, S., Donoso, L.A., Lee, W.-H. and Lee, E.Y.-H.P. (1990) DNA-binding activity of retinoblastoma protein is intrinsic to its carboxyl-terminal region. Cell Growth Diff., 1, 233-239.
20. Goulian, M. and C.J. Heard (1989) Intact DNA polymerase α/primase from mouse cells. J. Biol. Chem., 264, 19407-19415.
21. Srivastava, V., Schroeder, M., Miller, S. and Busbee, D. (1993) A comparison of DNA polymerase α from untransformed and SV40-transformed human fibroblasts. Int. J. Biochem., 25, 1053-1063.
22. Savoysky, E., Suzuki, M., Tamai, K., Sakurai, T., Ohuchi, T., Akiyama, T., Kojima, K. and Yoshida, S. (1992) Efficient purification of a full length and biochemically active p110Rb, the retinoblastoma gene product. Biochem. Biophys. Res. Commun., 187, 697-702.
23. Ludlow, J.W., Glendening, C.L., Livingston, D.M. and DeCaprio, J.A. (1993) Specific enzymatic dephosphorylation of the retionblastoma protein. Mol. Cell. Biol., 13, 367-372.
24. Hays, R., Caputo, J., Chen, T.R., Macy, M., McClintock, P. and Reid, Y. (Eds.) (1994) ATCC Cell Lines and Hybridomas: 8th Edn., ATCC, Rockville, MD.
25. Stahl, H., Dröge, P. and Knippers, R. (1986) DNA helicase activity of SV40 large tumor antigen. EMBO J., 5, 1939-1944.
26. DeCaprio, J.A., Ludlow, J.W., Figge, J., Shew, J.-Y., Huang, C.-M., Lee, W.-H., Marsilio, E., Paucha, E. and Livingston, D.M. (1988) SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell, 54, 275-283.
27. Mole, S.E., Gannon, J.V., Anton, I.A., Ford, M.J. and Lane, D.P. (1989) Host proteins that bind to or mimic SV40 large T antign: using antibodies to look at protein interactions and their significance. Immunology (Suppl.), 2, 80-85.
28. Manfredi, J.J. and Prives, C. (1990) Binding of p53 and p105Rb is not sufficient for oncogenic transformation by a hybrid polyoma virus-simian virus 40 large T antigen. J. Virol., 64, 5250-5259.
29. Cegielska, A. and Virshup, D.M. (1993) Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase, casein kinase I. Mol. Cell. Biol., 13, 1202-1211.
30. Savoysky, E., Suzuki, M., Simbulan, C., Tamai, K., Ohuchi, T., Akiyama, T. and Yoshida, S. (1993) Immunopurified Rb protein inhibits SV40 T antigen-dependent stimulation of DNA polymerase alpha. Oncogene, 8, 319-325.
31. Lohman, T.M. (1993) Helicase catalyzed DNA unwinding. J. Biol. Chem., 268, 2269-2272.
32. Huang, S., Wang, N.-P., Tseng, B.Y., Lee, W.-H. and Lee, E.Y.-H.P. (1990) Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO J., 9, 1815-1822.
33. Zhu, J., Rice, P.W., Gorsch, L., Abate, M. and Cole, C.N. (1991) The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53. J. Virol., 65(12), 6872-6880.
34. Alberts, A.S., Thorburn, A.M., Shenolikar, S., Mumby, M.C. and Feramisco, J.R. (1993) Regulation of cell cycle progression and nuclear affinity of the retionblastoma protein by protein phosphatases. Proc. Natl. Acad. Sci. USA, 90, 388-392.
35. Lee, W.-H., Hollingsworth, R.E., Qian, Y.-W., Chen, P.-L., Hong, F. and Lee, E.Y.-H.P. (1991) RB protein as a cellular 'corral' for growth-promoting proteins. Cold Spring Harbor Symp. Quant. Biol., 56, 211-217.
36. Wiman, K.G. (1993) The retinoblastoma gene: role in cell cycle control and cell differentiation. FASEB J., 7 841-845.
37. Bernard, S. (1989) Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein. Proc. Natl. Acad. Sci. USA, 86, 6474-6478.