Two distinct populations of primary cytotoxic cells infiltrating into allografted tumor rejection sites: Infiltration of macrophages cytotoxic against allografted tumor precedes that of multiple sets of cytotoxic T lymphocytes with distinct specificity to alloantigens

Microbiology and Immunology

Volumn 41, Issue 2, 1997, Pages 149-159

  Yoshida, Ryotaro ^a   Matsuura, Akihiro ^b   Einaga, Kuniko ^a   Ushio, Yumiko ^a   Yamamoto, Naoki ^a   Yoneda, Yukio ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

FACS; Macrophages; Transplantation; Tumor

Indexed keywords

ALLOANTIGEN; CONCANAVALIN A;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; CELL POPULATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FIBROSARCOMA; FLOW CYTOMETRY; GRAFT REJECTION; IMMUNOMODULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN;

EID: 0031052361     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.1997.tb01180.x     Document Type: Article

References (40)

1. Ascher, N.L., Ferguson, R.M., Hoffman, R., and Simmons, R.L. 1979. Partial characterization of cytotoxic cells infiltrating sponge matrix allografts. Transplantation 27: 254-259.
2. Bach, F.H., and Sachs, D.H. 1987. Transplantation immunity. New Engl. J. Med. 317: 489-492.
3. Cate, R.L., Mattaliano, R.J., Hession, C., Tizard, R., Farber, N.M., Cheung, A., Ninfa, E.G., Frey, A.Z., Gash, D.J., Chow, E.P., Fisher, R.A., Bertonis, J.M., Torres, G., Wallner, B.P., Ramachandran, K.L., Ragin, R.C., Manganaro, T.F., MacLaughlin, D.T., and Donahoe, P.K. 1986. Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells. Cell 45: 685-698.
4. Eckels, D. 1990. Alloreactivity: allogeneic presentation of endogenous peptides or direct recognition of MHC polymorphism. Tissue Antigens 35: 49-55.
5. + cytotoxic T lymphocyte clones. J. Exp. Med. 156: 1280-1285.
6. Fisher, D.A., Hunt, S.W. III, and Hood, L. 1985. Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse. J. Exp. Med. 162: 528-545.
7. Hansel, T.T., Pound, J.D., Pilling, D., Kitas, G.D., Salmon, M., Gentle, T.A., Lee, S.S., and Thompson, R.A. 1989. Purification of human blood eosinophils by negative selection using immunomagnetic beads. J. Immunol. Methods 122: 97-103.
8. Heber-Katz, E., Schwartz, R.H., Matis, L.A., Hannum, C., Fairwell, T., Appella, E., and Hansburg, D. 1982. Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation. J. Exp. Med. 155: 1086-1099.
9. Hunig, T., and Bevan, M.J. 1981. Specificity of T cell clones illustrates altered self hypothesis. Nature 294: 460-462.
10. + cytotoxic T lymphocytes by dendritic cells. J. Exp. Med. 166: 182-194.
11. Kärre, K., Ljunggren, H.G., Piontek, G., and Kiesling, R. 1985. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319: 675-678.
12. Katoh, K., Takahashi, Y., Hayashi, S., and Kondoh, H. 1987. Improved mammalian vectors for high expression of G418 resistance. Cell Struct. Funct. 12: 575-580.
13. d histocompatibility antigen. Nucleic Acid Res. 11: 1567-1577.
14. Lechler, R.I., Batchelor, J.R., and Lombardi, G. 1991. The relationship between MHC restricted and allospecilic T cell recognition. Immunol. Lett. 29: 41-50.
15. Lechler, R.I., Lombardi, G., Batchelor, J.R., Reinsmoen, N., and Bach, F.H. 1990. The molecular basis of alloreactivity. Immunol. Today 11: 83-88.
16. Ljunggren, H.G., and Kärre, K. 1990. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol. Today 11: 237-244.
17. Mason, D.W., and Morris, P.J. 1986. Effector mechanisms in allograft rejection. Annu. Rev. Immunol. 4: 119-145.
18. d gene by T cells of the mouse. Immunogenetics 30: 156-161.
19. - T cell receptor αβ T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection. J. Exp. Med. 174: 193-201.
20. Nakayama, E., and Uenaka, A. 1985. Effect of in vivo administration of Lyt antibodies. Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection. J. Exp. Med. 161: 345-355.
21. + T cells. Proc. Natl. Acad. Sci. U.S.A. 91: 3171-3175.
22. Nussenzweig, M.C., Steinman, R.M., Gutchinov, B., and Cohn, Z.A. 1980. Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J. Exp. Med. 152: 1070-1084.
23. 2-microglobulin-transfected Daudi cells. J. Immunol. 141: 17-20.
24. Rosenthal, A.S., and Shevach, E.M. 1973. Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes. J. Exp. Med. 138: 1194-1212.
25. Sanchez-Bueno, A., Verkhusha, V., Tanaka, Y., Takikawa, O., and Yoshida, R. 1996. Interferon-γ-dependent expression of inducible nitric oxide synthase, interleukin-12, and interferon-γ-inducing factor in macrophages elicited by allografted tumor cells. Biochem. Biophys. Res. Commun. 224: 555-563.
26. Sherman, A.L., and Chattopadhyay, S. 1993. The molecular basis of allorecognition. Annu. Rev. Immunol. 11: 385-402.
27. Shimizu, Y., and DeMars, R. 1989. Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell-mediated lysis is inversely correlated with HLA class I antigen expression. Eur. J. Immunol. 19: 447-451.
28. Snell, G.D. 1976. Recognition structure determined by the H-2 complex. Transplant. Proc. 8: 147-156.
29. Steinmetz, M., Malissen, M., Hood, L.E., Orn, A., Maki, R.A., Dastoornikoo, G.R., Stephan, D., Gibb, E., and Romaniuk, R. 1984. Tracts of high or low sequence divergence in the mouse major histocompatibility complex. EMBO J. 3: 2995-3003.
30. Stephan, D., Sun, H., Lindahl, K., Meyer, E., Hammerling, G., Hood, L.E., and Steinmetz, M. 1986. Organization and evolution of D region class I genes in the mouse major histocompatibility complex. J. Exp. Med. 163: 1227-1244.
31. Storkus, W.J., Alexander, J., Payne, J.A., Dawson, J.R., and Cresswell, P. 1989. Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes. Proc. Natl. Acad. Sci. U.S.A. 86: 2361-2364.
32. Takikawa, O., Habara-Ohkubo, A., and Yoshida, R. 1990. IFN-γ is the inducer of indoleamine 2,3-dioxygenase in allografted tumor cells undergoing rejection. J. Immunol. 145: 1246-1259.
33. Takikawa, O., Oku, T., Yasui, H., and Yoshida, R. 1993. Synergism between IFN-γ and IL-1α/β in growth inhibition of an allografted tumor. J. Immunol. 151: 2070-2076.
34. Takikawa, O., Oku, T., Ito, N., Ushio, Y., Yamamoto, N., Yoneda, Y., Tsuji, J., Sanchez-Bueno, A., Verkhusha, V., and Yoshida, R. 1996. Multiple expression of Ly-6C and accumulation of a Ly-6C pre-mRNA in activated macrophages involved in rejection of an allografted tumor. Biochem. Biophys. Res. Commun. 226: 247-253.
35. + helper T cells recognizing class II alloantigens. J. Immunol. 144: 2425-2435.
36. Ushio, Y., Yamamoto, N., Sanchez-Bueno, A., and Yoshida, R. 1996. Failure to reject an allografted tumor after elimination of macrophages in mice. Microbiol. Immunol. 40: 489-498.
37. Yim, C.-Y., McGregor, J.R., Kwon, O.-D., Bastian, N.R., Rees, M., Mori, M., Hibbs, J.B., Jr., and Samlowski, W.E. 1995. Nitric oxide synthesis contributes to IL-2-induced antitumor responses against intraperitoneal Meth A tumor. J. Immunol. 155: 4382-4390.
38. Yoshida, R., Park, S.W., Yasui, H., and Takikawa, O. 1988. Tryptophan degradation in transplanted tumor cells undergoing rejection. J. Immunol. 141: 2819-2823.
39. Yoshida R., Takikawa, O., Oku, T., and Habara-Ohkubo, A. 1991. Mononuclear phagocytes: a major population of effector cells responsible for rejection of allografted tumor cells in mice. Proc. Natl. Acad. Sci. U.S.A. 88: 1526-1530.
40. Zinkernagel, R.M., and Doherty, P.C. 1974. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248: 701-702.