Role of interleukin-6 in mediating mesangial cell proliferation and matrix production in vivo

Kidney International

Volumn 51, Issue 1, 1997, Pages 69-78

  Eitner, F ^a   Westerhuis, R ^a   Burg, M ^a   Weinhold, B ^a   Grone, H J ^a   Ostendorf, T ^a   Ruther, U ^a   Koch, K M ^a   Rees, A J ^a   Floege, J ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GLOMERULOPATHY; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MESANGIUM CELL; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRASTRUCTURE;

EID: 0031052252     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.9     Document Type: Article

References (60)

1. L.A. Slomowitz S. Klahr G.F. Schreiner I. Ichikawa Progression of renal disease N Engl J Med 319 1988 1547 1548
2. L.J. Striker E.P. Peten S.J. Elliot T. Doi G.E. Striker Mesangial cell turnover: Effect of heparin and peptide growth factors Lab Invest 64 1991 446 456
3. J. Floege M.W. Burns C.E. Alpers A. Yoshimura P. Pritz K. Gordon R.A. Seifert D.F. Bowen Pope W.G. Couser R.J. Johnson Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model Kidney Int 41 1992 297 309
4. C.M. Pesce L.J. Striker E. Peten S.J. Elliot G.E. Striker Glomerulosclerosis at both early and late stages is associated with increased cell turnover in mice transgenic for growth hormone Lab Invest 65 1991 601 605
5. T. Moriyama M. Fujibayashi Y. Funjiwara T. Kaneko C. Xia E. Imai T. Kamada A. Ando N. Ueda Angiotensin II stimulates interleukin-6 release from cultured mouse mesangial cells J Am Soc Nephrol 6 1995 95 101
6. C. Gomez Guerrero M.J. Lopez Armada E. Gonzalez J. Egido Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation J Immunol 154 1994 5247 5256
7. A. Amore F. Cavallo E. Bocchietto F. Bussolino B. Gianoglio L. Peruzzi M.G. Porcellini R. Coppo Cytokine mRNA expression by cultured rat mesangial cells after contact with environmental lectins Kidney Int 43 Suppl 39 1993 S41 S46
8. F. Abbott J.J. Ryan M. Ceska K. Matsushima C.E. Sarraf A.J. Rees Interleukin-1 beta stimulates human mesangial cells to synthesize and release interleukins-6 and -8 Kidney Int 40 1991 597 605
9. C. Ruef M. Kashgarian D.L. Coleman Mesangial cell-matrix interactions: Effects on mesangial cell growth and cytokine secretion Am J Pathol 141 1992 429 439
10. H.H. Radeke J.E. Gessner P. Uciechowski H.J. Magert R.E. Schmidt K. Resch Intrinsic human glomerular mesangial cells can express receptors for IgG complexes (Fc gamma RIII-A) and the associated Fc epsilon RI gamma-chain J Immunol 153 1994 1281 1292
11. M.E.A. van den Dobbelsteen F.J. van der Woude W.E.M. Schroeijers A.W. Bake L.A. van Es M.R. Daha Binding of dimeric and polymeric IgA to rat renal mesangial cells enhances the release of interleukin 6 Kidney Int 46 1994 512 519
12. C. Ruef K. Budde J. Lacy W. Northemann M. Baumann R.B. Sterzel D.L. Coleman Interleukin 6 is an autocrine growth factor for mesangial cells Kidney Int 38 1990 249 257
13. Y. Horii A. Muraguchi M. Iwano T. Matsuda T. Hirayama H. Yamada Y. Fujii K. Dohi H. Ishikawa Y. Ohmoto K. Yoshizaki T. Hirano T. Kishimoto Involvement of IL-6 in mesangial proliferative glomerulonephritis J Immunol 143 1989 3949 3955
14. C. Zoja A. Benigni G. Piccinini M. Figliuzzi L. Longaretti G. Remuzzi Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture Mediators Inflamm 2 1993 429 433
15. D. Malide P. Russo M. Bendayan Presence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients Hum Pathol 26 1995 558 564
16. Y. Horii M. Iwano E. Hirata H. Shiiki Y. Fujii K. Dohi H. Ishikawa Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis Kidney Int 43 Suppl 39 1993 S71 S75
17. A. Fukatsu S. Matsuo Y. Yuzawa H. Miyai A. Futenma K. Kato Expression of interleukin 6 and major histocompatibility complex molecules in tubular epithelial cells of diseased human kidneys Lab Invest 69 1993 58 67
18. R. Waldherr I.L. Noronha Z. Niemir C. Kruger H. Stein G. Stumm Expression of cytokines and growth factors in human glomerulo-nephritides Pediatr Nephrol 7 1993 471 478
19. K. Yoshioka T. Takemura K. Murakami M. Okada K. Yagi H. Miyazato K. Matsushima S. Maki In situ expression of cytokines in IgA nephritis Kidney Int 44 1993 825 833
20. K. Dohi M. Iwano A. Muraguchi Y. Horii T. Hirayama S. Ogawa H. Shiiki T. Hirano T. Kishimoto H. Ishikawa The prognostic significance of urinary interleukin 6 in IgA nephropathy Clin Nephrol 35 1991 1 5
21. K. Ohta N. Takano A. Seno A. Yachie T. Miyawaki H. Yokoyama N. Tomosugi E. Kato N. Taniguchi Detection and clinical usefulness of urinary interleukin-6 in the diseases of the kidney and the urinary tract Clin Nephrol 38 1992 185 189
22. R.B. Sterzel E. Schulze Lohoff M. Marx Cytokines and mesangial cells Kidney Int 43 Suppl 39 1993 S26 S31
23. M. Goldman D. Baran P. Druet Polyclonal activation and experimental nephropathies Kidney Int 34 1988 141 150
24. J. Floege N. Topley J. Hoppe T.B. Barrett K. Resch Mitogenic effect of platelet-derived growth factor in human glomerular mesangial cells: Modulation and/or suppression by inflammatory cytokines Clin Exp Immunol 86 1991 334 341
25. F. Abbott F.W.K. Tam J.J. Ryan A.J. Rees Human mesangial cells synthesize interleukin 1 alpha but not interleukin 1 beta, interleukin 1 receptor antagonist, or tumour necrosis factor Nephrol Dial Transplant 7 1992 997 1001
26. M. Ikeda U. Ikeda T. Ohara E. Kusano S. Kano Recombinant interleukin-6 inhibits the growth of rat mesangial cells in culture Am J Pathol 141 1992 327 334
27. C. Gordon N. Richards A.J. Howie K. Richardson J. Michael D. Adu P. Emery Urinary IL-6: A marker for mesangial proliferative glomerulonephritis Clin Exp Immunol 86 1991 145 149
28. V. Poli R. Balena E. Fattori A. Markatos M. Yamamoto H. Tanaka G. Ciliberto G.A. Rodan F. Costantini Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion Embo J 13 1994 1189 1196
29. T. Yamamoto C.B. Wilson Quantitative and qualitative studies of antibody-induced mesangial cell damage in the rat Kidney Int 32 1987 514 525
30. R.J. Johnson R.L. Garcia P. Pritzl C.E. Alpers Platelets mediate glomerular cell proliferation in immune complex nephritis induced by anti-mesangial cell antibodies in the rat Am J Pathol 136 1990 369 374
31. O. Skalli P. Ropraz A. Trzeciak G. Benzonana D. Gillessen G. Gabbiani A monoclonal antibody against alpha-smooth muscle actin: A new probe for smooth muscle differentiation J Cell Biol 103 1986 2787 2796
32. M. Altmannsberger K. Weber R. Droste M. Osborn Desmin is a specific marker for rhabdomyosarcomas of human and rat origin Am J Pathol 118 1985 85 95
33. R.J. Johnson C.E. Alpers A. Yoshimura D. Lombardi P. Pritzl J. Floege S.M. Schwartz Renal injury from angiotensin II-mediated hypertension Hypertension 19 1992 464 474
34. N.J. Gonchoroff J.A. Katzmann R.M. Currie E.L. Evans D.W. Houck B.C. Kline P.R. Greipp M.R. Loken S-phase detection with an antibody to bromodeoxyuridine. Role of DNAse pretreatment J Immunol Meth 93 1986 97 101
35. C.D. Dijkstra E.A. Dopp P. Joling G. Kraal The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macrophage subpopulations in the rat recognized by monoclonal antibodies EDI, ED2 and ED3 Immunology 54 1985 589 599
36. W.M. Bagchus M.F. Jeunink J. Rozing J.D. Elema A monoclonal antibody against rat platelets. Tissue distribution in vitro and in vivo Clin Exp Immunol 75 1989 317 323
37. V. Kliem R.J. Johnson C.E. Alpers A. Yoshimura W.G. Couser K.M. Koch J. Floege Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats Kidney Int 49 1996 666 678
38. R.J. Johnson H. Iida C.E. Alpers M.W. Majesky S.M. Schwartz P. Pritzl K. Gordon A.M. Gown Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation J Clin Invest 87 1991 847 858
39. H.C. Birnboim Rapid extraction of high molecular weight RNA from cultured cells and granulocytes for Northern analysis Nucl Acids Res 16 1988 1487 1497
40. V. Glisin R. Crkvenjakow C. Byus Ribonucleic acid isolation by cesium chloride centrifugation Biochemistry 13 1974 2633 2637
41. J. Sambrook E.F. Fritsch T. Maniatis Molecular Cloning: A Laboratory Manual 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor
42. M.L. Iruela-Arispe C.A. Diglio E.H. Sage Proteins produced by endothelial cells undergoing angiogenesis in vitro Arterioscler Thromb 21 1991 805 815
43. A.M. Karkar F.W.K. Tam A.E.I. Proudfoot A. Meager A.J. Rees Modulation of antibody-mediated glomerular injury in vivo by interleukin-6 Kidney Int 44 1993 967 973
44. J. Floege R.J. Johnson K. Gordon H. Iida P. Pritzl A. Yoshimura C. Campbell C.E. Alpers W.G. Couser Increased synthesis of extracellular matrix in mesangial proliferative nephritis Kidney Int 40 1991 477 488
45. C.E. Alpers R.A. Seifert K.L. Hudkins R.J. Johnson D.F. Bowen-Pope Developmental patterns of PDGF B-chain, PDGF-receptor and alpha-actin expression in human glomerulogenesis Kidney Int 42 1992 390 399
46. P. Leveen M. Pekny S. Gebre-Medhin B. Swollin E. Larsson C. Betsholtz Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities Genes Dev 8 1994 1875 1887
47. P. Soriano Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice Genes Dev 8 1994 1887 1896
48. V. Cattell J.W.B. Bradfield Focal mesangial proliferative glomerulonephritis in the rat caused by Habu snake venom Am J Pathol 87 1977 511 524
49. B. Ryffel M. Kammüller R. Robison L. Myers Pathology induced by interleukin-6 Toxicol Lett 64/65 1992 311 319
50. B. Ryffel B.D. Car H. Gunn D. Roman P. Hiestand M.J. Mihatsch Interleukin-6 exacerbates glomerulonephritis in (NZBxNZW)F-l mice Am J Pathol 144 1994 927 937
51. J. Floege E. Eng V. Lindner C.E. Alpers B.A. Young M.A. Reidy R.J. Johnson Rat glomerular mesangial cells synthesize basic fibroblast growth factor. Release, upregulated synthesis, and mitogenicity in mesangial proliferative glomerulonephritis J Clin Invest 90 1992 2362 2369
52. J. Floege E. Eng B.A. Young C.E. Alpers T.B. Barrett D.F. Bowen Pope R.J. Johnson Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats J Clin Invest 92 1993 2952 2962
53. J. Floege W. Kriz M. Schulze M. Susani D. Kerjaschki A. Mooney W.G. Couser K.M. Koch Basic FGF (FGF-2) augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy J Clin Invest 96 1995 2809 2819
54. Y. Jyo T. Sasaki H. Tamai T. Nohno N. Itoh G. Osawa Demonstration of fibroblast growth factor receptor mRNA in glomeruli in mesangial proliferative nephritis by in situ hybridization J Am Soc Nephrol 5 1994 784 (abstract)
55. H. Iida R. Seifert C.E. Alpers R.G.K. Gronwald P.E. Phillips P. Pritzl K. Gordon A.M. Gown R. Ross D.F. Bowen Pope R.J. Johnson Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat Proc Natl Acad Sci USA 88 1991 6560 6564
56. S. Okuda L.R. Languino E. Ruoslahti W.A. Border Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix J Clin Invest 86 1990 453 462
57. G.H. Tesch D.J. Nikolic-Paterson H.Y. Lan R.C. Atkins IL-1 receptor antagonist inhibits mesangial cell proliferation in rat anti-Thy-1 nephritis J Am Soc Nephrol 6 1995 886 (abstract)
58. V. Montinaro K. Hevey L. Aventaggiato K. Fadden A. Esparza A. Chen D.S. Finbloom A. Rifai Extrarenal cytokines modulate the glomerular response to IgA immune complexes Kidney Int 42 1992 341 353
59. A.M. Karkar J. Smith F.W.K. Tam A.E.I. Proudfoot A.J. Rees Abrogation of glomerular injury in nephrotoxic nephritis by continuous infusion of interleukin-6 J Am Soc Nephrol 6 1995 834 (abstract)
60. B.K. Finck B. Chan D. Wofsy Interleukin 6 promotes murine lupus in NZB/NZW F1 mice J Clin Invest 94 1994 585 591