Noninterference of cytochrome P4501A2 in the cytotoxicity of tacrine using genetically engineered V79 Chinese hamster cells for stable expression of the human or rat isoform and two human hepatocyte cell lines

Biochemical Pharmacology

Volumn 53, Issue 3, 1997, Pages 423-427

  Benoit, Guy G ^a   Naud, Carole F ^a   Simard, Marc A ^a   Astier, Alain L ^a  

^a HENRI MONDOR HOSPITAL   (France)

Author keywords

Chinese hamster cell lines; cytochrome P4501A2; genetically engineered cells; human hepatocyte cell lines; tacrine; toxicity

Indexed keywords

CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; PROTEIN; RNA; TACRINE; VELNACRINE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL STRAIN V 79; CELL VIABILITY; CHINESE HAMSTER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; GENETIC ENGINEERING; HUMAN; HUMAN CELL; LIVER CELL; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA SYNTHESIS;

ANIMALS; CELL LINE; CRICETINAE; CRICETULUS; CYTOCHROME P-450 CYP1A2; GENETIC ENGINEERING; HUMANS; LIVER; PROTEIN BIOSYNTHESIS; RATS; RNA; TACRINE;

EID: 0031052015     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00713-7     Document Type: Article

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