Mechanisms of adaptive supersensitivity: Correlation of guinea pig atrial supersensitivity with modifications in adenylyl cyclase activity

Biochemical Pharmacology

Volumn 53, Issue 3, 1997, Pages 347-356

  Roberts, Mark I ^a   Stadel, Jeffrey M ^b   Torphy, Theodore J ^b   Fleming, William W ^a   Taylor, David A ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

adaptation; adenylyl cyclase; cardiac muscle; G proteins; guinea pig; supersensitivity

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CHOLERA TOXIN; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANYLYLIMIDODIPHOSPHATE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; PERTUSSIS TOXIN; PROTEIN SUBUNIT; RADIOLIGAND; RESERPINE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADAPTATION; ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GUINEA PIG; HEART ATRIUM; HEART LEFT ATRIUM; HEART RIGHT ATRIUM; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SUPERSENSITIVITY;

ADAPTATION, PHYSIOLOGICAL; ADENOSINE DIPHOSPHATE RIBOSE; ADENYLATE CYCLASE; ANIMALS; GTP-BINDING PROTEINS; GUINEA PIGS; HEART ATRIA; MALE; RECEPTORS, ADRENERGIC, BETA; RESERPINE;

EID: 0031051742     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00717-4     Document Type: Article

References (26)

1. Fleming WW and Westfall DP, Adaptive supersensitivity. In: Catecholamines, Handbook of Pharmacology (Eds. Trendelenburg U and Weiner N), Vol. 90/1, pp. 509-559. Springer, Heidelberg, 1988.
2. Fleming WW and Taylor DA, Cyclic AMP and adaptive supersensitivity in guinea-pig atria. J Neural Transm 34 (Suppl): 179-185, 1991.
3. Fleming, WW, McPhillips JJ and Westfall DP, Postjunctional supersensitivity and subsensitivity of excitable tissues to drugs. Ergeb Physiol 68: 55-119, 1973.
4. Hawthorn MH, Taylor DA and Fleming WW, Characteristics of adaptive supersensitivity in the left atrium of the guinea-pig. J Pharmacol Exp Ther 241: 453-457, 1987.
5. Tenner TE, Young J, Riker BJ and Ramanadham S, Non-specific supersensitivity induced by reserpine in guinea-pig cardiac ventricle tissue. J Pharmacol Exp Ther 246: 1-6, 1988.
6. Hawthorn MH and Broadley KJ, β-Adrenoceptor ligand binding and supersensitivity to isoprenaline of ventricular muscle after chronic reserpine pretreatment. Naunyn Schmiedebergs Arch Pharmacol 320: 240-245, 1982.
7. Roberts MI, Biser PS, Stadel JM, Taylor DA and Fleming WW, Adenylyl cyclase and G-proteins in supersensitive guinea pig ventricles. Mol Pharmacol 42: 784-791, 1992.
8. 125I]iodohydroxybenzylpindolol binding sites in the guinea-pig right atrium. J Pharmacol Exp Ther 223: 352-362, 1982.
9. i. Br J Pharmacol 100: 223-230, 1990.
10. Holmer SR and Homcy CJ, G proteins in the heart: A redundant and diverse transmembrane signaling network. Circulation 84: 1891-1902, 1991.
11. Seamon KB and Daly JW, Forskolin: Its biological and chemical properties. In: Advances in Cyclic Nucleotide and Protein Phosphorylation Research (Eds. Greengard P and Robison GA), Vol. 20, pp. 1-150. Raven Press, New York, 1986.
12. Laurenza A, McHugh-Sutkowski E and Seamon KB, Forskolin: A specific stimulator of adenylyl cyclase or a diterpine with multiple sites of action. Trends Pharmacol Sci 10: 442-447, 1989.
13. Levitski A, From epinephrine to cAMP. Science 241: 800-806, 1988.
14. Roberts MI, Stadel JM, Torphy TJ, Taylor DA and Fleming WW, Alterations in adenylyl cyclase activity may account for reserpine induced supersensitivity in guinea-pig left atria. Pharmacologist 33: 173, 1991.
15. Leyden AF, Pomerantz E and Bouchard EF, Pharmaceutical aspects of reserpine. J Am Pharm Assoc 45: 771-775, 1956.
16. Crout JR, Muskus AE and Trendelenberg U, Effect of tyramine on isolated guinea-pig right atria in relation to their noradrenaline stores. Br J Pharmacol 18: 600-611, 1962.
17. Taylor DA, Westfall DP, DeMoraes S and Fleming WW, The effect of pretreatment with reserpine on the diastolic potential of guinea-pig atrial cells. Naunyn Schmiedebergs Arch Pharmacol 293: 81-87, 1976.
18. McMurchie EJ, Patten GS, Charnock JS and McLennan PL, The interaction of dietary fatty acid and cholesterol on catecholamine-stimulated adenylate cyclase activity in the rat heart. Biochim Biophys Acta 898: 137-153, 1987.
19. Bradford MM, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
20. Salomon Y, Adenylate cyclase assay. Adv Cyclic Nucleotide Res 10: 35-55, 1979.
21. Laemmli UK, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
22. - cells. Mol Pharmacol 39: 702-710, 1991.
23. Luetje CW, Tieje KM, Christian JL and Nathanson NM, Differential tissue expression and developmental regulation of guanine nucleotide-binding regulatory proteins and their messenger RNAs in rat heart. J Biol Chem 263: 13357-13365, 1988.
24. i with antisera prepared against synthetic peptides. J Clin Invest 83: 2050-2062, 1989.
25. Clapham DE, Direct G protein activation of ion channels? Annu Rev Neurosci 17: 441-464, 1994.
26. Tang W-J and Gilman AG, Adenylyl cyclases. Cell 70: 869-872, 1992.