Scleroderma: A disease related to damaged proteins?

Nature Medicine

Volumn 3, Issue 3, 1997, Pages 276-278

  Peng, Stanford L ^a   Fatenejad, Saeed ^a   Craft, Joe ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; PEPTIDE;

AUTOIMMUNITY; HUMAN; ISCHEMIA; NOTE; PRIORITY JOURNAL; SCLERODERMA;

AUTOANTIBODIES; AUTOANTIGENS; HUMANS; ISCHEMIA; SCLERODERMA, SYSTEMIC;

SCLERODERMA;

EID: 0031051740     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0397-276     Document Type: Note

References (12)

1. Seibold, J.R. Scleroderma. in Textbook of Rheumatology (eds. Kelley, W.N., Harris, E.D., Ruddy, S. & Sledge, C.B.) 1133-1162 (W.B. Saunders Company, Philadelphia, 1997).
2. Casciola-Rosen, L., Wigley, F. & Rosen, A. Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. J. Exp. Med. 185, 71-79 (1997).
3. Takeuchi, K., Turley, S.J., Tan, E.M. & Pollard, K.M. Analysis of the autoantibody response to fibrillarin in human disease and murine models of autoimmunity. J. Immunol. 154, 961-971 (1995).
4. Casciola-Rosen, L.A., Anhalt, G.J. & Rosen, A. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med. 182, 1625-1614 (1995).
5. Carvalho, D., Savage, C.O., Black, C.M. & Pearson, J.D. IgG anti-endothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines. J. Clin. Invest. 97, 111-119 (1996).
6. Sankar, S. et al. Modulation of transforming growth factor β receptor levels on microvascular endothelial cells during in vitro angiogenesis. J. Clin. Invest. 97, 1436-1446 (1996).
7. McAllister, K.A. et al. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nature Genet. 8, 345-351 (1994).
8. Bruckdorfer, K.R., Hillary, J.B., Bunce, T., Vancheeswaran, R. & Black, C.M. Increased susceptibility to oxidation of low-density lipoproteins isolated from patients with systemic sclerosis. Arth. Rheum. 38, 1060-1067 (1995).
9. Kuwana, M., Medsger, T.A., Jr. & Wright, T.M. T and B cell collaboration is essential for the autoantibody response to DNA topoisomerase I in systemic sclerosis. J. Immunol. 155, 2703-2714 (1995).
10. Lehmann, P.B., Sercarz, E.E., Forsthuber, T., Dayan, C.M. & Gammon, G. Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today 14, 203-208 (1993).
11. Lanzavecchia, A. How can cryptic epitopes trigger autoimmunity? J. Exp. Med. 181, 1945-1948 (1995).
12. Wigley, F.M. Raynaud's phenomenon and other features of scleroderma, including pulmonary hypertension. Curr. Opin. Rheumatol. 8, 561-568 (1996).