Analysis of CD9, CD32 and p67 signalling: Use of degranulated platelets indicates direct involvement of CD9 and p67 in integrin activation

British Journal of Haematology

Volumn 96, Issue 2, 1997, Pages 275-286

  Slupsky, Joseph R ^a,c   Cawley, John C ^a   Kaplan, Cécile ^b   Zuzel, Mirko ^a,d  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^b INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE   (France)

^c KERCKHOFF HEART CENTER   (Germany)

^d Duncan Building   (United Kingdom)

Author keywords

CD32; CD9; platelets; PTA1; signalling

Indexed keywords

CD32 ANTIGEN; CD9 ANTIGEN; FC RECEPTOR; INTEGRIN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PROTEIN P67; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE MEMBRANE;

EID: 0031051357     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.d01-2011.x     Document Type: Article

References (49)

1. Aitken, M.L., Ginsberg, M.H., Byers-Ward, V. & Plow. E.F. (1990) Effects of OKM-5, a monoclonal antibody to glycoprotein IV, on platelet aggregation and thrombospondin surface expression. Blood, 76, 2501-2509.
2. Anderson, G.P. & Anderson. C.L. (1990) Signal transduction by the platelet Fc receptor. Blood, 76, 1165-1172.
3. Anderson, G.P., van de Winkel, J.G.J. & Anderson, C.L. (1991) Anti-gpIIb/IIIa (CD41) monoclonal antibody-induced platelet activation requires Fc receptor-dependent cell-cell interaction. British Journal of Haematology, 79, 75-83.
4. Bachelot, C., Cano, E., Grelac, F., Saleun, S., Druker, B.J., Levy-Toledano, S., Fisher, S. & Rendu, F. (1992) Functional implications of tyrosine phosphorylation in platelets. Biochemical Journal, 284, 923-928.
5. Bachelot. C., Rendu, F., Boucheix, C., Hogg, N. & Levy-Toledano, S. (1990) Activation of platelets by mAB P256 specific for glycoprotein IIb-IIIa: possible evidence for role for IIb/IIIa in membrane signal transduction. European Journal of Biochemistry, 190, 177-183.
6. Badwey, J.A., Erickson, R.W. & Curnutte, J.T. (1991) Staurosporine inhibits the soluble and membrane-bound protein tyrosine kinases of human neutophils. Biochemical and Biophysical Research Communications, 178, 423-429.
7. Berndt, M.C., Mazurov, A.V., Vinogradov, D.V., Burns, G.F. & Chesterman, C.N. (1993) Topographical association of the platelet Fc-receptor with the glycoprotein IIb-IIIa complex. Platelets, 4, 190-195.
8. Blake, R.A., Walker, T.R. & Watson, S.P. (1993) Activation of human platelets by peroxyvanadate is associated with tyrosine phosphorylation of phospholipase Cγ and formation of inositol phosphates. Biochemical Journal, 280, 471-475.
9. Ferrell, J.E., Jr & Martin, G.S. (1988) Platelet tyrosine-specfic protein phosphorylation is regulated by thrombin. Molecular Cell Biology, 8, 3603-3610.
10. Golden, A. & Brugge, J.S. (1989) Thrombvin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proceedings of the National Academy of Sciences of the United States of America, 86, 905-901.
11. Haimovich, B., Lipfert, L., Brugge, J.S. & Shattil, S.J. (1993) Tyrosine phosphorylation and cytoskeletal reorganisation in platelets are triggered by interaction of integrin receptors with their immobilised ligands. Journal of Biological Chemistry, 268, 15868-15877.
12. Hato, T., Ikeda, K., Yasukawa, M., Watanabe, A. & Kobayashi, Y. (1988) Exposure of platelet fibrinogen receptors by a monoclonal antibody to CD9 antigen. Blood, 72, 224-229.
13. Hillery, C.A., Smyth, S.S. & Parise, L.V. (1991) Phosphorylation of human platelet glycoprotein IIIa (gpIIIa) in vitro. Journal of Biological Chemistry, 266, 14663-14669.
14. Horsewood, P., Hayward, C.P.M., Warkentin, T.E. & Kelton, J.G. (1991) Investigation of monoclonal antibody-induced platelet activation. Blood, 78, 1019-10126.
15. FAK. Journal of Cell Biology, 122, 473-483.
16. Hunziker, W., Koch, T., Whitney, J.A. & Mellman, I. (1990) Fc receptor phosphorylation during receptor-mediated control of B-cell activation. Nature, 345, 628-632.
17. Hynes, R.O. (1992) Integrins: versatility, modulation and signalling in cell adhesion. Cell, 69, 11-25.
18. Ierino, F.L., Hulett, M.D., McKenzie, I.F.C. & Hogarth, P.M. (1993) Mapping epitopes of human FcγRII (CDw 32) with monoclonal antibodies and recombinant receptors. Journal of Immunology, 150, 1794-1803.
19. Kaplan, K.L., Brockman, M.J., Chernoff, A., Leszik, G.R. & Drillings, M. (1979) Platelet αgranule proteins: studies on release and subcellular localisation. Blood, 53, 604-618.
20. Kinlough-Rathbone, R.L., Packham, M.A. Guccionne, M.A., Richardson, M., Harfenist, E.J. & Mustard, J.F. (1991) Characteristics of thrombin-degranulated human platelets: development of a method that does not use proteolytic enzymes for deaggregation. Thrombosis and Haemostasis, 65, 403-410.
21. Kozma, L.M., Rossomando, A.J. & Weber, M.J. (1991) Comparison of three methods for detecting tyrosine phosphorylated proteins. Methods in Enzymology, 201, 28-43.
22. Kroll, M.H. & Schafer, A.I. (1989) Biochemical mechanisms of platelet activation. Blood, 74, 1181-1195.
23. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
24. Lanza, F., Wolf, D., Fox, C.F., Kieffer, N., Seyer, J.M., Fried, V.A., Cougling, S.R., Phillips, D.R. & Jennings, L.K. (1991) cDNA cloning and expression of platelet p24/CD9: evidence for a new family of multiple membrane-spanning proteins. Journal of Biological Chemistry, 266, 10638-10645.
25. Letarte, M., Seehafer, J.G., Greaves, A., Masellis-Smith, A. & Shaw, A.R.E. (1993) Homotypic aggregation of pre-B leukemic cell lines by antibodies to VLA integrins correlates with their expression of CD9. Leukemia, 7, 93-103.
26. Masellis-Smith, A. & Shaw, A.R.E. (1994) CD9-regulated adhesion: anti-CD9 monoclonal antibodies induce pre-B-cell adhesion to bone marow fibroblasts through a de novo recognition of fibronectin. Journal of Immunology, 152, 2768-2777.
27. McCrae, K.R., Shattil, S.J. & Cines, D.B. (1990) Platelet activation induces increased Fcγ receptor expression. Journal of Immunology, 144, 3920-3927.
28. +2. Biochemical Journal, 269, 513-519.
29. Morel, M-C., Lecompte, T., Chapeix, P., Favier, R., Potecin, F., Samama, M., Salmon, C. & Kaplan, C. (1989) PL2-49, a monoclonal antibody against glycoprotein IIb which is a platelet activator. British Journal of Haematology, 71, 57-63.
30. Morii, N., Teru-uchi, T., Tominaga, T., Kumangai, N., Kozak, S., Ushikubi, F. & Narumiya, S. (1992) A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation. Journal of Biological Chemistry, 267, 20921-20926.
31. Mustard, J.F., Kinlough-Rathbone, R.L. & Packham, M.A. (1989) Isolation of human platelets from plasma by centrifugation and washing. Methods in Enzymology, 169, 3-11.
32. Ozaki, Y., Matsumoto, Y., Yatomi, Y., Higashihara, M. & Kume, S. (1991) Two-step mobilisation of arachidonic acid in platelet activation induced by low concentrations of TP82. a monoclonal antibody against CD9 antigen. European Journal of Biochemistry, 199, 347-354.
33. Packham, M.A., Livne, A-A., Ruben, D.H. & Rand, M.L. (1993) Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid. Biochemical Journal, 290, 849-856.
34. Parise, L.V., Criss, A.B., Nannizzi, L. & Wardell, M.R. (1990) Glycoprotein IIIa is phosphorylated in intact human platelets. Blood, 75, 2363-2368.
35. Pumiglia, K.M., Lau, L-F., Huang, C-K., Burroughs, S. & Feinstein, M.B. (1992) Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). Biochemical Journal, 286, 441-449.
36. Reimers, H-J., Baker, R.K. & Joist, J.H. (1987) Impaired thromboxane synthesis in preactivated human blood platelets: agonist-specific. irreversible desensitisation to thrombin. Thrombosis Research, 48, 535-548.
37. 2 synthesis from endogenous precursors in the presence of normal cyclooxygenase activity. Blood, 63, 858-865.
38. Rubenstein, E., Boucheix, C., Urso, I. & Carroll, R.C. (1991a) Fcγ receptor-mediated interplatelet activation by a monoclonal antibody against β2 microglobulin. Journal of Immunology, 147, 3040-3046.
39. Rubenstein, E., Kouns, W.C., Jennings, L.K., Boucheix, C. & Carroll, R.C. (1991b) Interaction of two gpIIb/IIIa monoclonal antibodies with platelet Fc receptor (FcγRII). British Journal of Haematology, 77, 80-86.
40. Scott, J.L., Dunn, S.M., Jin, B., Hillam, A.J., Walton, S., Berndt, M.C., Murray, A.W., Krissansen, G.W. & Burns, G.F. (1989) Characterisation of a novel membrane glycoprotein involved in platelet activation. Journal of Biological Chemistry, 264, 13475-13482.
41. Slupsky, J.R., Cawley, J.C., Griffith, L.S., Shaw, A.R.E. & Zuzel, M. (1992) Role of FcγRII in platelet activation by monoclonal antibodies. Journal of Immunology, 148, 3189-3194.
42. Slupsky, J.R., Seehafer, J.G., Tang, S-C., Masellis-Smith, A. & Shaw, A.R.E. (1989) Evidence that monoclonal antibodies against CD9 antigen induce specific association between CD9 and the platelet gpIIb/IIIa complex. Journal of Biological Chemistry, 264, 12289-12293.
43. Smythe, S.S., Joneckis, C.C. & Parise, L.V. (1993) Regulation of vascular integrins. Blood, 81, 2827-2843.
44. Stockschlader, M. & Scharf, R.E. (1989) Failure of preactivated human blood platelets to restore defective thromboxane synthesis despite prolonged incubation in plasma. Thrombosis and Haemostasis, 62, 1016-1022.
45. 2 in platelet cytotoxicity activated by receptors for immunoglobulin G and complement. Journal of Experimental Medicine, 177, 937-947.
46. 2+ and protein kinase C is the major factor in determining the level of secretion from human platelets. Biochemical Journal, 289, 277-282.
47. Worthington, R.E., Carroll, R.C. & Boucheix, C. (1990) Platelet activation by CD9 monoclonal antibodies is mediated by the FcγRII receptor. British Journal of Haematology, 74, 216-222.
48. Yatomi, Y., Ozaki, Y., Satoh, K. & Kume, S. (1995) Anti-CD9 monoclonal antibody elicits staurosporine inhibitable phosphatidylinositol 4,5-bisphosphate hydrolysis, phosphatidylinositol 3,4-bisphosphate synthesis, and protein-tyrosine phosphorylation in human platelets. FEBS Letters, 32, 285-290.
49. Zuzel, M., Walton, S., Burns, G.F., Berndt, M.C. & Cawley, J.C. (1991) A monoclonal antibody to a 67kD cell membrane glycoprotein directly induces persistent plalelet aggregation independently of granule secretion. British Journal of Haematology, 79, 466-473.