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Volumn 32, Issue 2, 1997, Pages 95-102
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Synthesis and pharmacological evaluation of some amino-acid-containing cyproheptadine derivatives as dual antagonists of histamine H1- and leukotriene D4-receptors
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Author keywords
Antiasthmatic acitivity; Antihistamine activity; Drug design; Dual antagonist; H1 receptor; In vitro asthma model; Leukotriene D4 antagonist
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Indexed keywords
2 BENZYLOXYCARBONYLAMINO 3 [4 (10,11 DIHYDRO 5H DIBENZO[A,D]CYCLOHEPTEN 5 YLOXY)PIPERIDIN 1 YL]PROPIONIC ACID;
7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID;
ANTIASTHMATIC AGENT;
ANTIHISTAMINIC AGENT;
CYPROHEPTADINE;
CYPROHEPTADINE DERIVATIVE;
LEUKOTRIENE D4;
LEUKOTRIENE D4 RECEPTOR;
LEUKOTRIENE RECEPTOR BLOCKING AGENT;
MEPYRAMINE;
TERFENADINE;
UNCLASSIFIED DRUG;
ANIMAL TISSUE;
ARTICLE;
ASTHMA;
BLOOD BRAIN BARRIER;
BRAIN CORTEX;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG RECEPTOR BINDING;
DRUG SYNTHESIS;
GUINEA PIG;
ILEUM;
IN VITRO STUDY;
MALE;
MOUSE;
NONHUMAN;
SMOOTH MUSCLE CONTRACTION;
STRUCTURE ACTIVITY RELATION;
TRACHEA;
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EID: 0031051342
PISSN: 02235234
EISSN: None
Source Type: Journal
DOI: 10.1016/S0223-5234(97)87535-6 Document Type: Article |
Times cited : (21)
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References (20)
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