Synthesis and pharmacological evaluation of some amino-acid-containing cyproheptadine derivatives as dual antagonists of histamine H1- and leukotriene D4-receptors

European Journal of Medicinal Chemistry

Volumn 32, Issue 2, 1997, Pages 95-102

  Zhang, M Q ^a   Van De Stolpe, A ^a   Zuiderveld, O P ^a   Timmerman, H ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Antiasthmatic acitivity; Antihistamine activity; Drug design; Dual antagonist; H1 receptor; In vitro asthma model; Leukotriene D4 antagonist

Indexed keywords

2 BENZYLOXYCARBONYLAMINO 3 [4 (10,11 DIHYDRO 5H DIBENZO[A,D]CYCLOHEPTEN 5 YLOXY)PIPERIDIN 1 YL]PROPIONIC ACID; 7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID; ANTIASTHMATIC AGENT; ANTIHISTAMINIC AGENT; CYPROHEPTADINE; CYPROHEPTADINE DERIVATIVE; LEUKOTRIENE D4; LEUKOTRIENE D4 RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MEPYRAMINE; TERFENADINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ASTHMA; BLOOD BRAIN BARRIER; BRAIN CORTEX; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; ILEUM; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION; TRACHEA;

EID: 0031051342     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)87535-6     Document Type: Article

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