The reversal of multidrug resistance in multicellular tumor spheroids by SDZ PSC 833

Anticancer Research

Volumn 17, Issue 1 A, 1997, Pages 129-133

  Ehrlich, Paul H ^a   Moustafa, Zeinab A ^a   Archinal Mattheis, Ann E ^a   Newman, Michael J ^a   Bair, Kenneth W ^a   Cohen, Dalia ^a  

^a Sandoz Pharma Ltd   (Switzerland)

Author keywords

Multidrug resistance (MDR); P glycoprotein; SDZ PSC 833; Spheroids

Indexed keywords

DOXORUBICIN; PACLITAXEL; VALSPODAR;

ARTICLE; BREAST CARCINOMA; CELL AGGREGATION; CONTROLLED STUDY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MONOLAYER CULTURE; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; SOLID TUMOR; TUMOR SPHEROID;

CYCLOSPORINS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; HUMANS; NEOPLASMS; P-GLYCOPROTEIN; PACLITAXEL; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 0031051155     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Gottesman MM and Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385- 427, 1993.
2. Ford JM and Hait WN: Pharmacologic circumvention of multidrug resistance. Cytotechnology 12: 171-212, 1993.
3. Boesch D, Gavériaux C, Jachez B, Pourtier-Manzanedo A, Bollinger P and Loor F: In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res 57: 4226-4233, 1991.
4. Sutherland RM: Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240: 177-184, 1988.
5. Murphy BJ, Laderoute KR, Vreman HJ, Grant TD, Gill NS, Stevenson DK and Sutherland RM: Enhancement of heme oxygenase expression and activity in A431 squamous carcinoma multicellular tumor spheroids. Cancer Res 53: 2700-2703, 1993.
6. Theodorescu D Sheehan C and Kerbel RS: TGF-β gene expression depends on tissue architecture. In vitro Cell Dev Biol 29A: 105-108, 1993.
7. Erlichman C and Vidgen D: Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids, and xenografts in immune-deprived mice. Cancer Res 44: 5369-5375, 1984.
8. Erlichman C and Wu A: Resistance of MGH-U1 bladder cancer spheroids to vincristine. Anticancer Res 12: 1233-1236, 1992.
9. Kobayashi H, Man S, Graham CH, Kapitain SJ, Teicher BA and Kerbel RS: Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc Nat Acad Sci USA 90: 3294-3298, 1993.
10. Görlach A, Herter P, Hentschel H, Frosch PJ and Acker H: Effects of nIFN β and rIFN α on growth and morphology of two human melanoma cell lines: comparison between two- and three-dimensional culture. Int J Cancer 56: 249-254, 1994.
11. Wei LY and Roepe PD: Low external pH and osmotic shock increase the expression of human MDR protein. Biochemistry 33: 7229-7238, 1994.
12. Muller C, Laurent G and Ling V: P-glycoprotein stability is affected by serum deprivation and high cell density in multidrug-resistant cells. J Cellular Physiology 163: 538-544, 1995.
13. Sakata K, Kwok TT, Gordon GR, Waleh NS and Sutherland RM: Resistance of verapamil sensitization of multidrug-resistant cells grown as multicellular spheroids. Int J Cancer 59: 282-286, 1994.
14. Jachez B, Nordmann R and Loor F: Restoration of taxol sensitivity of multidrug resistant cells by the cyclosporine analogue SDZ PSC 833 and the cyclopeptolide SDZ 280-446. J Nat Cancer Inst 85: 478-483, 1993.
15. Zacherl J, Hamilton G, Thalhammer T, Riegler M, Cosentini EP, Ellinger A, Bischof G, Schweitzer M, Teleky B, Koperna T et al: Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH. Cancer Chemother Pharmacol 34: 125-132, 1994.
16. Archinal-Mattheis A, Rzepka RW, Watanabe T, Kokubu N, Itoh Y, Combates NJ, Bair KW and Cohen D: Analysis of the interactions of SDZ PSC 833 ([3′-keto-Bmt1]-[Val2]-Cyclosporine), a multidrug resistance modulator, with P-glycoprotein. Oncology Res 7: 603-610, 1995.
17. Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, Vaigro-Wolf A, Gray-Goodrich M, Campbell H, Mayo J and Boyd M: Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Nat Cancer Inst 83: 757-766, 1991.
18. Roy SN and Horwitz SB: A phosphoglycoprotein associated with taxol resistance in J774.2 cells. Cancer Res 45: 3856-3863, 1985.
19. Cianfriglia M, Willingham MC, Tombes M, Scagliotti GV, Frasca G and Chersi A: P-glycoprotein epitope mapping. I. Identification of a linear human-specific epitope in the fourth loop of the P-glycoprotein extracellular domain by MM4.17 murine monoclonal antibody to human multi-drug-resistant cells. Int J Cancer 56: 153-160, 1994.