Nelson's syndrome: A review

Endocrinologist

Volumn 7, Issue 1, 1997, Pages 5-9

  Kemink, S A G ^a   Smals, A G H ^a   Hermus, A R M M ^a   Pieters, G F F M ^a   Kloppenborg, P W C ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; SOMATOSTATIN DERIVATIVE;

ADRENALECTOMY; CANCER RADIOTHERAPY; CORTICOTROPIN RELEASE; CUSHING SYNDROME; DISEASE ASSOCIATION; GENE MUTATION; HUMAN; NELSON SYNDROME; NEUROSURGERY; PATHOGENESIS; REVIEW;

EID: 0031051137     PISSN: 10512144     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019616-199707010-00002     Document Type: Review

References (50)

1. Nelson D, Meakin J, Dealy J, Matson D, Emerson K, Thorn G: ACTH-producing tumor of the pituitary gland. N Engl J Med 1958; 259: 161-4.
2. Nelson D, Meakin J, Thorn G: ACTH-producing pituitary tumors following adrenalectomy for Cushing's syndrome. Ann Intern Med 1960; 52: 560-9.
3. Liddle G: The George M. Kober Lecture. "Cushing's syndrome - 1980." Trans Assoc Am Physicians 1980; 93: 40-51.
4. Bamberger C, Schulte H, Chrousos G: Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocrine Reviews 1996; 17: 245-61.
5. Karl M, von Wichert G, Kempter E, et al.: Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene. J Clin Endocrinol Metab 1996; 81: 124-9.
6. Reuss W, Saeger W, Lüdecke D: Electron microscopical morphometry of well-differentiated and undifferentiated ACTH secreting adenomas in Cushing's disease and Nelson's syndrome. Virchows Archiv A Pathol Anat 1991; 419: 395-401.
7. Saeger W, Geisler F, Lüdecke D: Pituitary pathology in Cushing's disease. Pathol Res Pract 1988; 183: 592-5.
8. Fehn M, Farquharson M, Sautner D, Saeger W, Lüdecke D, McNicol A: Demonstration of pro-opiomelanocortin mRNA in pituitary adenomas and para-adenomatous gland in Cushing's disease and Nelson's syndrome. J Pathol 1993; 169: 335-9.
9. Oldfield E, Schulte H, Chrousos G, et al.: Corticotropin-releasing hormone (CRH) stimulation in Nelson's syndrome: response of adrenocorticotropin secretion to pulse injection and continuous infusion of CRH. J Clin Endocrinol Metab 1986; 62: 1020-6.
10. Goverde H, Martens G, Pesman G, Smals A: Multiple forms of bioactive and immunoreactive adrenocorticotropin in human pituitary and blood of patients with Nelson's syndrome. J Clin Endocrinol Metab 1993; 77: 443-7.
11. Nelson D, Sprunt J, Mims R: Plasma ACTH determinations in 58 patients before and after adrenalectomy for Cushing's syndrome. J Clin Endocrinol Metab 1966; 26: 722-8.
12. Hopwood N, Kenny F: Incidence of Nelson's syndrome after adrenalectomy for Cushing's disease in children. Am J Dis Child 1977; 131:1353-6.
13. Thomas C, Smith A, Benson M, Griffith J: Nelson's syndrome after Cushing's disease in childhood: a continuing problem. Surgery 1984; 96: 1067-77.
14. Kemink L, Pieters G, Hermus A, Smals A, Kloppenborg P: Patient's age is a simple predictive factor for the development of Nelson's syndrome after total adrenalectomy for Cushing's disease. J Clin Endocrinol Metab 1994; 79: 887-9.
15. Horký K, Kan̄ka J, Gregorová I, Tomsová Z, Dvoráková J: Je mozná predikce výoje Nelsonova syndromu u Cushingovy choroby po bilaterální adrenalektomii? Cas Lek Ces 1990; 129: 645-9.
16. Kasperlik-Zaluska A, Nielubowicz J, Wislawski J, et al.: Nelson's syndrome: incidence and prognosis. Clin Endocrinol 1983; 19: 693-8.
17. Kelly W, MacFarlane I, Longson D, Davies D, Sutcliffe H: Cushing's disease treated by total adrenalectomy: long-term observations of 43 patients. Quarterly Journal of Medicine, New Series LII 1983; 206: 224-31.
18. Moore T, Dluhy R, Williams G, Cain J: Nelson's syndrome: frequency, prognosis, and effect of prior pituitary irradiation. Ann Intern Med 1976; 85: 731-4.
19. Ambrosi B, Bochicchio D, Riva E, Faglia G: Effects of sodium valproate administration on plasma ACTH levels in patients with ACTH hypersecretion. J Endocrinol Invest 1983; 6: 305-6.
20. Jenkins P, Trainer P, Plowman P, et al.: The long term outcome after adrenalectomy and prophylactic pituitary radiotherapy in adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab 1994; 79: 165-71.
21. Moreira A, Castro M, Machado H: Longitudinal evaluation of adrenocorticotrophin and beta-lipotrophin plasma levels following bilateral adrenalectomy in patients with Cushing's disease. Clin Endocrinol 1993; 39: 91-6.
22. Sonino N, Zielezny M, Fava G, Fallo F, Boscaro M: Risk factors and long-term outcome in pituitary-dependent Cushing's disease. J Clin Endocrinol Metab 1996; 81: 2647-52.
23. Orth D, Liddle G: Results of treatment in 108 patients with Cushing's syndrome. N Engl J Med 1971; 285: 243-7.
24. Kuhn J, Proeschel M, Seurin D, Bertagna X, Luton J, Girard F: Comparative assessment of ACTH and Lipotropin plasma levels in the diagnosis and follow-up of patients with Cushing's syndrome: a study of 210 cases. Am J Med 1989; 86: 678-84.
25. Hewlett T, Plowman P, Wass J, Rees L, Jones A, Besser G: Megavoltage pituitary irradiation in the management of Cushing's disease and Nelson's syndrome: long-term follow-up. Clin Endocrinol 1989; 31: 309-23.
26. Littley M, Shalet S, Beardwell C, Ahmed S, Sutton M: Long-term follow-up of low-dose external pituitary irradiation for Cushing's disease. Clin Endocrinol 1990; 33: 445-55.
27. Grua J, Nelson D: ACTH-producing pituitary tumors. Endocrinol Metab Clin of North Am 1991; 20: 319-62.
28. Tyrrell J, Wilson C: Cushing's disease; therapy of pituitary adenomas. Endocrinol Metab Clin of North Am 1994; 23: 925-38.
29. Wilson C, Tyrell J, Fitzgerald P, Pitts L: Cushing's disease and Nelson's syndrome. Clin Neurosurg 1980; 27: 19-29.
30. Fukushima T: Transsphenoidal microsurgical treatment of Nelson's syndrome. Neurosurg Rev 1985; 8: 185-94.
31. Wislawski J, Kasperlik-Zaluska A, Jeske W, et al.: Results of microsurgical treatment by a transsphenoidal approach in 10 patients with Nelson's syndrome. J Neurosurg 1985; 62: 68-71.
32. Laws E: Surgical management of pituitary tumors. In Endocrine Tumors, edited by Mazzaferri E, Damaan N, pp. 215-220, Cambridge, MA, Blackwell Scientific Publications 1993.
33. Tran L, Blount L, Horton D, Sadeghi A, Parker R: Radiation therapy of pituitary tumors: results in 95 cases. Am J Clin Oncol 1991; 14: 25-9.
34. Littley M, Shalet S, Beardwell C, Ahmed S, Applegate S, Sutton M: Hypopituitarism following external radiotherapy for pituitary tumours in adults. Quarterly J Med 1989; 70: 145-60.
35. Littley M, Shalet S, Beardwell C, Robinson C, Sutton M: Radiation-induced hypopituitarism is dose-dependent. Clin Endocrinol 1989; 31: 363-73.
36. Sheline G: Radiation therapy of pituitary tumours. In Hormone Secreting Pituitary Tumours, edited by Givens JR, pp. 121-143, Chicago, Year Book Medical Publishers Inc, 1982.
37. Ganz J, Backlund E, Thorsen F: The effects of Gamma Knife Surgery of pituitary adenomas on tumor growth and endocrinopathies. Stereotact Funct Neurosurg 1993; 61 (suppl 1): 30-7.
38. Elias A, Gwinup G, Valenta L: Effects of valproic acid, naloxone, and hydrocortisone in Nelson's syndrome and Cushing's disease. Clin Endocrinol 1981; 15: 151-4.
39. Kelly W, Adams J, Laing I, Longson D, Davies D: Long-term treatment of Nelson's syndrome with sodium valproate. Clin Endocrinol 1988; 28: 195-204.
40. Kasperlik-Zaluska A, Drac-Kaniewska J, Migdalska B, Jeske W, Wísniewska-Wózniak T: The effect of sodium valproate on plasma ACTH and cortisol concentrations in Cushing's disease and Nelson's syndrome. Endokrynologia Polska 1988; 39: 245-52.
41. Loli P, Berselli M, Frascatani F, Muratori F, Tagliaferri M: Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion. J Endocrinol Invest 1984; 7: 93-6.
42. Gwinup G, Elias A, Choi B: Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma. Acta Endocrinol 1984; 105: 449-54.
43. Kasperlik-Zaluska A, Migdalska B, Jeske W, Drac-Kaniewska J, Wísniewska-Wózniak T: The effect of magnesium valproate on plasma ACTH concentrations in Nelson's syndrome. Acta Med Pol 1989; 30: 9-15.
44. Baranowska B, Jeske W, Misiorowski W, Dorobek W, Zgliczýnski S: The effect of Naloxone on the secretion of pituitary hormones in patients with Cushing's disease and Nelson's syndrome. Endokrynologia Polska 1986; 37: 203-10.
45. Kasperlik-Zaluska A, Jeske W, Migdalska B, Jastrzebska H: Failure of Indomethacin to suppress plasma adrenocorticotropin levels and β-endorphin-like immunoreactivity in Nelson's syndrome. Endokrynologia Polska 1987; 38: 243-6.
46. Jimenez Reina I, Leal-Cerro A, Garcia J, Garcia-Luna P, Astorga R, Bernal G: in vitro effects of Ketokonazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome. Acta Endocrinol 1989; 121: 185-90.
47. Tyrrell J, Lorenzi M, Gerich J: Inhibition by somatostatin of ACTH secretion in Nelson's syndrome. J Clin Endocrinol Metab 1975; 40: 1125-7.
48. Lamberts S, Uitterlinden P, Klijn F: The effect of the long-acting somatostatin analogue SMS 201-995 on ACTH secretion in Nelson's syndrome and Cushing's disease. Acta Endocrinol (Copenh) 1989; 120: 760-6.
49. Petrini L, Gasperi M, Pilosu R, Marcello A, Martino E: Long-term treatment of Nelson's syndrome by octreotide: a case report. J Endocrinol Invest 1994; 17: 135-9.
50. Guerin V, Ortega F, James-Deidier A. Continuous infusion of SMS 201-995 in Nelson's syndrome (abstract). J Endocrinol Invest 1990; 13 (suppl 2): 153.