The pharmacokinetics of epidural lidocaine and bupivacaine during cesarean section

Anesthesia and Analgesia

Volumn 84, Issue 3, 1997, Pages 527-532

  Downing, John W ^a   Johnson, H Vernetta ^a   Gonzalez, Herbert F ^a   Arney, Timothy L ^a   Herman, Norman L ^b   Johnson, Raymond F ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BUPIVACAINE; LIDOCAINE;

ADULT; ARTICLE; CESAREAN SECTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; EPIDURAL ANESTHESIA; EPIDURAL DRUG ADMINISTRATION; FEMALE; HEMODYNAMICS; HUMAN; NORMAL HUMAN; OBSTETRIC ANESTHESIA; PLASMA CLEARANCE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANESTHESIA, EPIDURAL; BUPIVACAINE; CESAREAN SECTION; EPINEPHRINE; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; LIDOCAINE; PREGNANCY;

EID: 0031050996     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199703000-00011     Document Type: Article

References (25)

1. Gibbs CP, Krischer J, Peckham BM, et al. Obstetric anesthesia: a national survey. Anesthesiology 1986;65:298-306.
2. Lund PC, Cwik JC. A correlation of the differential penetration and the systemic toxicity of lidocaine, mepivacaine and prilocaine in man. Acta Anaesthesiol Scand Suppl 1966;23:475-82.
3. Braid DP, Scott DB. Dosage of lignocaine in epidural block in relation to toxicity. Br J Anaesth 1966;38:596-602.
4. Raj PP, Rosenblatt R, Miller J, et al. Dynamics of the local anesthetic compounds in regional anesthesia. Anesth Analg 1977;56:110-7.
5. Cole PC, McMorland GH, Jenkins LC, et al. Epidural blockade for cesarean section comparing lidocaine hydrocarbonate and lidocaine hydrochloride. Anesthesiology 1985;62:348-50.
6. Tucker GT, Mather LE. Pharmacology of local anaesthetic agents, pharmacokinetics of local anaesthetic agents. Br J Anaesth 1975;47:213-24.
7. Ramanathan J, Bottorff M, Jeter JN, et al. The pharmacokinetics and maternal and neonatal effects of epidural lidocaine in preeclampsia. Anesth Analg 1986;65:120-6.
8. Mazze RI, Dunbar RW. Plasma lidocaine concentrations after caudal, lumbar epidural, axillary block and intravenous regional anesthesia. Anesthesiology 1966;27:574-9.
9. Brum AGL, van Kleef JW, Gladines MPRR, et al. Epidural anesthesia with lidocaine and bupivacaine: effects of epinephrine on the plasma concentration profiles. Anesth Analg 1986; 65:1281-4.
10. Ohno H, Watanabe M, Saitoh J, et al. Effect of epinephrine concentration on lidocaine disposition during epidural anesthesia. Anesthesiology 1988;68:625-8.
11. Mather LE, Tucker GT, Murphy TM, et al. Effect of adding adrenaline to etdocaine and lignocaine in extradural anaesthesia. II. Pharmacokinetics. Br J Anaesth 1976a;48:989-94.
12. Tucker GT, Mather LE. Properties, absorption, and disposition of local anesthetic agents. In: Cousins MJ, Bridenbaugh PO, eds. Neural blockade in clinical anesthesia and management of pain. 2nd ed. Philadelphia: JB Lippincott, 1988:59-110.
13. Misra U, Pridie AK, Bower S, et al. Arterial and peripheral venous concentrations of bupivacaine following combined sciatic and femoral 3-in-1 block [abstract]. Br J Anaesth 1994;72: A.139.
14. Nolte H, al Saydali B, Weissenberg W. The concentration of free lidocaine in arterial, central venous and peripheral vein plasma following intravenous injection. Reg Anesth 1990;13:29-35.
15. Bachman MB, Biscoping J, Adams HA, et al. The significance of the sampling site in determination of plasma levels of local anaesthetics using 0.75% bupivacaine. Reg Anesth 1990;13: 16-20.
16. Tucker GT. Determination of bupivacaine (Marcaine) and other anilide-type local anesthetics in human blood and plasma by gas chromatography. Anesthesiology 1970;32:255-60.
17. Ha H, Funk B, Gerber H, Follath F. Determination of bupivacaine in plasma by high-performance liquid chromatography. Anesth Analg 1984;63:448-50.
18. Gillespie WR. Noncompartmental versus compartmental modelling in clinical pharmacokinetics. Clin Pharmacokinet 1991;20: 253-62.
19. Albright GA. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology 1979;51:285-7.
20. Reynolds F. A comparison of the potential toxicity of bupivacaine, lignocaine and mepivacaine during epidural blockade for surgery. Br J Anaesth 1971;43:567-71.
21. Liu PL, Feldman HS, Giasi R. Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine and tetracaine in awake dogs following rapid iv administration. Anesth Analg 1983;62:375-9.
22. Johnson RF, Herman N, Arney TL, et al. Bupivacaine transfer across the human term placenta. A study using the dual perfused human placental model. Anesthesiology 1995;82:459-68.
23. Morishima HO, Pedersen H, Santos AC, et al. Adverse effects of maternally administered lidocaine on the asphyxiated preterm fetal lamb. Anesthesiology 1989;71:110-5.
24. Mather LE, Cousins MJ. Local anesthetics and their current clinical use. Drugs 1979;18:185-205.
25. Reynolds F, Taylor G. Maternal and neonatal blood concentration of bupivacaine. Anaesthesia 1970;25:14-23.