Synthesis, binding affinity and intrinsic activity of new anilide derivatives of serotonin at human 5-HT(1D) receptors

European Journal of Medicinal Chemistry

Volumn 32, Issue 2, 1997, Pages 129-134

  Perez, M ^a   Ayerbe, N ^a   Fourrier, C ^a   Sigogneau, I ^a   Pauwels, P J ^a   Palmier, C ^a   John, G W ^a   Valentin, J P ^a   Halazy, S ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

5 HT(1D) receptor agonist; Anilide; Migraine; Serotonin; Sumatriptan

Indexed keywords

ANILIDE; CYCLIC AMP; N [4 (METHANESULFONAMIDO)PHENYL] 2 [3 (2 AMINOETHYL) 1H INDOL 5 YLOXY]ACETAMIDE; NARATRIPTAN; RECEPTOR SUBTYPE; SEROTONIN 1D RECEPTOR; SEROTONIN RECEPTOR; SULFONAMIDE; SUMATRIPTAN; UNCLASSIFIED DRUG; ZOLMITRIPTAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; MIGRAINE; NONHUMAN; SAPHENOUS VEIN; STRUCTURE ACTIVITY RELATION; VASOCONSTRICTION;

EID: 0031050731     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)87539-3     Document Type: Article

References (23)

1. 1 Hoyer D, Clarke DE, Fozard JR et al (1994) Pharmacol Rev 46, 157-203
2. 2 Feniuk W, Humphrey PPA (1992) Drug Dev Res 26, 235-240
3. 3 Ferrari MD, Saxena PR (1993) Trends Pharmacol Sci 14, 129-133
4. 4 Moskowitz MA (1992) Trends Pharmacol Sci 13, 307-311
5. 5 Hamel E, Grégoire L, Lau B (1993) Eur J Pharmacol 242, 75-82
6. 6 Hamel E et al (1993) Mol Pharmacol 44, 242-246
7. 7 Rebeck GW, Maynard KI, Hyman BT, Moskowitz MA (1994) Proc Natl Acad Sci USA 11, 3666-3669
8. 8 Glen RC, Martin GR, Hill AP et al (1995) J Med Chem 38, 3566-3580
9. 9 Connor HE, O'Shaughnessy CT, Feniuyk W et al (1993) Proc Br Pharmacol Soc (Jan 5-7, Cambridge), abstr C107
10. 10 Street LJ, Baker R, Davey WB et al (1995) J Med Chem 38, 1799-1810
11. 11 Perez M, Pauwels P, Palmier C, John GW, Valentin JP, Halazy S (1995) Bioorg Med Chem Lett 5, 663-666
12. 12 Glennon RA, Hong SS, Bondarev M et al (1996) J Med Chem 39, 314-322
13. 13 Hong SS, Dukat M, Teitler M et al (1995) Med Chem Res 5, 690-699
14. 14 Perez M, Fourrier C, Sigogneau I et al (1995) J Med Chem 38, 3602-3607
15. 15 Castro JL, Baker R, Guiblin AR et al (1994) J Med Chem 37, 3023-3032
16. 16 Frank WC, Kim YC, Heck RF (1978) J Org Chem 15, 2947-2952
17. 17 Pauwels PJ, Palmier C, Colpaert FC (1995) Cell Pharmacol 2, 49-57
18. 18 Pauwels PJ, Van Compel P, Leysen JE (1993) Biochem Pharmacol 45, 375-383
19. 19 Martin GR, MacLennan SJ (1990) Naunyn-Schmiedeb Arch Pharmacol 342, 111-119
20. 20 Street LJ, Baker R, Castro JL et al (1993) J Med Chem 36, 1529-1538
21. 21 Valentin JP, Bonnafous R, Jorand C et al (1995) Pharmacol Res 31, 156
22. 22 Perez M, Pauwels PJ, Palmier C, John GW, Valentin JP, Halazy S (1995) Med Chem Res 5, 680-689
23. 23 Marquardt DW (1963) J Soc Indust Appl Math 11, 431