Hepatic amino acid and protein metabolism in non-anorectic, moderately cachectic tumor-bearing rats

Journal of Hepatology

Volumn 26, Issue 2, 1997, Pages 396-408

  Blaauw, Ivo De ^a   Deutz, Nicolaas E P ^a   Boers, Willem ^b   Von Meyenfeldt, Maarten F ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b Trop Med AIDS E0127 Acad M   (Netherlands)

Author keywords

acute phase proteins; amino acids; cancer; gluconeogenesis; metabolism; protein turnover; ureagenesis

Indexed keywords

ALPHA 2 MACROGLOBULIN; AMINO ACID; UREA;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CACHEXIA; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; ISOTOPE LABELING; LIVER FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT; SARCOMA; TUMOR;

EID: 0031050628     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80058-X     Document Type: Article

References (63)

1. Kern KA, Norton JA. Cancer cachexia. J Parenter Enteral Nutr. 12:1988;286-298.
2. Norton JA, Shamberger R, Stein TP, Milne GW, Brennan MF. The influence of tumor-bearing on protein metabolism in the rat. J Surg Res. 30:1981;456-462.
3. Douglas RG, Shaw JH. Metabolic effects of cancer. Br J Surg. 77:1990;246-254.
4. Christensen HN. Interorgan amino acid nutrition. Physiol Rev. 62:1982;1193-1233.
5. Souba WW. Glutamine and Cancer. Ann Surg. 218:1993;715-728.
6. Fahr MJ, Kornbluth J, Blossom S, Schaeffer R, Klimberg VS, Harry M. Glutamine enhances immunoregulation of tumor growth. J Parenter Enteral Nutr. 18:1994;471-476.
7. Welbourne TC, King AB, Horton K. Enteral glutamine supports hepatic glutathione efflux during inflammation. J Nutr Biochem. 4:1993;236-242.
8. Billiar TR, Curran RD. Kupffer cell and hepatocyte interactions: a brief overview. J Parenter Enteral Nutr. 14:1990;175S-180S.
9. Warren RS, Jeevanandam M, Brennan MF. Protein synthesis in the tumor-influenced hepatocyte. Surger. 98:1985;275-282.
10. Holroyde CP, Gabuzda TG, Putnam RC, Paul P, Reichard GA. Altered glucose metabolism in metastatic carcinoma. Cancer Res. 35:1975;3710-3714.
11. Lundholm K, Edstrom S, Karlberg I, Ekman L, Schersten T. Glucose turnover, gluconeogenesis from glycerol, and estimation of net glucose cycling in cancer patients. Cancer. 50:1982;1142-1150.
12. Inculet RI, Peacock JL, Gorschboth CM, Norton JA. Gluconeogenesis in the tumor-influenced rat hepatocyte: importance of tumor burden, lactate, insulin, and glucagon. J Natl Cancer Inst. 79:1987;1039-1046.
13. Burt ME, Lowry SF, Gorschboth C, Brennan MF. Metabolic alterations in a noncachectic animal tumor system. Cancer. 47:1981;2138-2146.
14. Lowry SF, Foster DM, Norton JA, Berman M, Brennan MF. Glucose disposal and gluconeogenesis from alanine in tumor-bearing Fischer 344 rats. J Natl Cancer Inst. 66:1981;653-658.
15. Nurjhan N, Bucci A, Periello G, Stumvoll M, Dailey G, Bier DM, Toft I, Jenssen TG, Gerich JE. Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J Clin Invest. 95:1995;272-277.
16. Chance WT, Cao L, Kim MW, Nelson JL, Fischer JE. Reduction of tumor growth following treatment with a glutamine antimetabolite. Life Sci. 42:1988;87-94.
17. Ekman L, Lundholm KG, Blackburn GL, Grant JP, Young VR. Is the liver or the periphery limiting for hepatic utilization of amino acids in cancer-induced malnutrition. Amino Acids, Metabolism and Medical Applications. 1983;213-217 John Wright, PSG Inc, London.
18. Beck SA, Tisdale MJ. Nitrogen excretion in cancer cachexia and its modification by a high fat diet in mice. Cancer Res. 49:1989;3800-3804.
19. Karlberg HI, Kern KA, Fischer JE. Albumin turnover in sarcoma-bearing rats in relation to cancer anorexia. Am J Surg. 145:1983;95-101.
20. Krause R, James JH, Humphrey C, Fischer JE. Plasma and brain amino acids in Walker 256 carcinosarcoma-bearing rats. Cancer Res. 39:1979;3065-3069.
21. Waldegrave W. Chairman Council of European Community. Guide for the Care and Use of Laboratory Animals. 1986;European Community, Brussels, Belgium. Publication 86/609.
22. Boyland E, Warren FL. The induction of tumours by methylcholanthrene in two strains of mice. J Path Bact. 45:1937;171-177.
23. Chen MK, Espat NJ, Bland KI, Copeland EM, Souba WW. Influence of progressive tumor growth on glutamine metabolism in skeletal muscle and kidney. Ann Surg. 217:1993;655-667.
24. Popp MB, Morrison SD, Brennan MF. Total parenteral nutrition in a methyl-cholanthrene-induced rat sarcoma model. Cancer Treat Rep. 65:1981;137-143. (Suppl 5).
25. de Blaauw I, Deutz NEP, von Meyenfeldt MF. Glutamine depletion and increased gut permeability in non-anorectic, nonweight-losing tumor-bearing rats. Gastroenterology. 108:1995;A721.
26. Morrison SD. In vivo estimation of size of experimental tumors. J Natl Cancer Inst. 71:1983;407-408.
27. van Gool J, van Vugt H, Helle M, Aarden LA. The relation among stress, adrenaline, interleukin 6 and acute phase proteins in the rat. Clin Immunol Immunopathol. 57:1990;200-210.
28. Dejong CHC, Kampman MT, Deutz NEP, Soeters PB. Altered glutamine metabolism in rat portal drained viscera and hindquarter during hyperammonemia. Gastroenterology. 102:1992;936-948.
29. de Blaauw I, Deutz NEP, von Meyenfeldt MF. In vivo amino acid metabolism of gut and liver during short and prolonged starvation. Am J Physiol. 270:1996;G298-G306.
30. Dejong CHC, Deutz NEP, Soeters PB. Renal ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat. J Clin Invest. 92:1993;2834-2840.
31. van Eijk HMH, Huinck MP, Rooyakkers DR, Deutz NEP. Automated simultaneous isolation and quantitation of labeled amino acid fractions from plasma and tissue by ion-exchange chromatography. Chromatogr B Biomed Appl. 660:1994;251-257.
32. Deutz NEP, Reijven PL, Anthanasas G, Soeters PB. Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs. Clin Sci. 83:1992;607-614.
33. Heeneman S, Deutz NEP. Effects of decreased glutamine supply on gut and liver metabolism in vivo in rats. Clin Sci. 85:1993;437-44.
34. Thomas JH, Gillham B, Thomas J, Gillham B. Plasma amino acids and utilization of amino acids by tissues. 2nd Edn. Wills' Biochemical Basis of Medicine. 1989;238-247 Wright, London.
35. Biolo G, Fleming Ry, Maggi SP, Wolfe RR. Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiol. 44:1995;E75-E84.
36. Shinnick FL, Harper AE. Branched-chain amino acid oxidation by isolated rat tissue preparations. Biochim Biophys Acta. 437:1976;477-486.
37. Warren RS, Jeevanandam M, Brennan MF. Comparison of hepatic protein synthesis in vivo vs. in vitro in the tumor bearing rat. J Surg Res. 42:1987;43-50.
38. Seglen PO, Solhein AE, Grinde B, Gordon PB, Schwarze PE, Gjessing RM, Poli A. Amino acid control of protein synthesis and degradation in isolated rat hepatocytes. Ann NY Acad Sci. 349:1980;1-17.
39. Norusis MJ. Statistical Package for Social Sciences (SPSS)/PC+ V4.0 Base Manual for the IBM PC/XT/AT and PS/2. 1989;SPSS Inc, Chicago, IL, USA.
40. Jennings G, Elia M. The acute-phase response to turpentine-induced abscesses in malnourished rats at different environmental temperatures. Metabolism. 41:1992;141-147.
41. de Blaauw I, Deutz NEP, Von Meyenfeldt MF. Increased whole body glutamine turnover in cancer is not matched by increased hindquarter glutamine release. Gastroenterology. 108:1995;A722.
42. Fafournoux P, Remesy C, Demigne C. Fluxes and membrane transport of amino acids in rat liver under different protein diets. Am J Physiol. 259:1990;E614-E625.
43. Heindorff HA. The hepatic catabolic stress response. Hormonal regulation of urea synthesis after surgery. Dan Med Bull. 40:1993;224-234.
44. Chance WT, Muggia Sullam M, Chen MH, Murphy RF, Fischer JE. Reversal of tumor-induced biochemical abnormalities by insulin treatment in rats. J Natl Cancer Inst. 77:1986;497-503.
45. Lowry SF, Norton JA, Gorschboth CM, Brennan MF. Glucose turnover and gluconeogenesis during hypocaloric glucose infusion in tumor-bearing F344 male rats. J Natl Cancer Inst. 64:1980;291-296.
46. Stovroff MC, Fraker DL, Norton JA. Cachectin activity in the serum of cachetic, tumour-bearing rats. Arch Surg. 124:1989;94-99.
47. Fearon KCH, McMillan Dc, Preston T, Winstanley P, Cruickshank AM, Shenkin A. Elevated circulating interleukin-6 is associated with an acute-phase response but reduced fixed hepatic protein synthesis in patients with cancer. Ann Surg. 213:1991;26-31.
48. Smith BK, Conn CA, Kluger MJ. Experimental cachexia: effects of MCA sarcoma in the Fischer rat. Am J Physiol. 265:1993;E376-R384.
49. Ardawi MS. Effects of epidermal growth factor and glutamine-supplemented parenteral nutrition on the small bowel of septic rats. Clin Sci. 82:1992;573-580.
50. Andersson c, Gelin J, Iresjo BM, Lundholm K. Acute-phase proteins in response to tumor growth. J Surg Res. 55:1993;607-614.
51. Andus T, Bauer J, Gerok W. Effects of cytokines on the liver. Hepatology. 13:1991;364-375.
52. Bereta J, Kurdowska A, Koj A, Hirano T, Kishimoto T, Content J, Fiers W, Van Damme J, Gauldie J. Different preparations of natural and recombinant human interleukin-6 (IFN-beta 2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes. Int J Biochem. 21:1989;361-366.
53. Singh J, Grigor MR, Thompson MP. Glucose Homeostasis in rats bearing a transplantable sarcoma. Cancer Res. 40:1980;1699-1706.
54. Philippidis H, Ballard FJ. The development of gluconeogenesis in rat liver. Effect of glucagon and ether. Biochem J. 120:1970;385-392.
55. Hers HG, Hue L. Gluconeogenesis and related aspects of glycolysis. Annu Rev Biochem. 52:1983;617-653.
56. Jennings G, Bourgeois C, Elia M. The magnitude of the acute phase protein response is attenuated by protein deficiency in rats. J Nutr. 122:1992;1325-1331.
57. Harper AE, Miller RH, Block KP. Branched chain amino acid metabolism. Annu Rev Nutr. 4:1984;409-454.
58. Sampson DA, Masor M, Jansen GR. Protein synthesis in rat tissues during lactation: no effect of diethyl ether anaesthesia. Biochem J. 224:1984;681-683.
59. Bessesen A, Morland J. Effects of anesthetics on protein synthesis in isolated rat hepatocytes: inhibition by diethyl ether in contrast to no influence by pentobarbital and tentanyl. Acta Pharmacol Toxicol Copenh. 57:1985;23-29.
60. Bessesen A, Smith Kielland A, Gadeholt G, Morland J. Reduced synthesis of hepatic and plasma proteins in rats during diethyl ether anaesthesia. Acta Pharmacol Toxicol Copenh. 54:1984;241-246.
61. James WPT, Coward WA, Waterlow JC, Stephen JML. Metabolism of plasma proteins. Nitrogen Metabolism in Man. 1981;457-473 ASC, London.
62. 2-macroglobulin. Biochem J. 238:1986;359-364.
63. Kilberg MS. Amino acid transport in isolated rat hepatocytes. J Membr Biol. 69:1982;1-12.