Food restriction reduces aflatoxin B1 (AFB1)-DNA adduct formation, AFB1-glutathione conjugation, and DNA damage in AFB1-treated male F344 rats and B6C3F1 mice

Journal of Nutrition

Volumn 127, Issue 2, 1997, Pages 210-217

  Chou, Ming W ^a   Chen, Wen ^a,b  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

aflatoxin B1 glutathione conjugates; aflatoxin B1 DNA adducts; food restriction; mice; rats

Indexed keywords

AFLATOXIN B1; EPOXIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PYRIMIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONJUGATION; DIET RESTRICTION; DNA ADDUCT; DNA DAMAGE; DNA STRAND; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; MALE; MOUSE; NONHUMAN; RAT; SPECIES DIFFERENTIATION; TISSUE SPECIFICITY;

EID: 0031050301     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.2.210     Document Type: Article

References (41)

1. Adam, W., Curci, R. & Edwards, J. O. (1989) Dioxiranes: a new class of powerful oxidants. Acc. Chem. Res. 22: 205-211.
2. Allaben, W. T., Chou, M. W. & Pegram, R. A. (1991) Dietary restriction and lexicological endpoints: a historical perspective. In: Biological Effects of Dietary Restriction (Fishbein, L., ed.), pp. 42-54. Springer-Verlag, Berlin, Germany.
3. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (1989) Labeling of DNA by random oligonucleotide-primed synthesis. Curr. Prot. Mol. Biol. 1, 3.5.9(a) and 2.2.3(b), Wiley-Interscience, New York, NY.
4. 7 adducts and inducing different genetic responses. Chem. Res. Toxicol. 2: 114-122.
5. Bailey, G. S. (1994) Role of aflatoxin-DNA adducts in the cancer process. In: The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance (Eaton, D. L. & Groopman, J. D., eds.), pp. 137-148. Academic Press, New York, NY.
6. Basnakian, A. G. & James, S. J. (1994) A rapid and sensitive assay for the detection of DNA fragmentation during early phases of apoptosis. Nucleic Acids Res. 22: 2714-2715.
7. Beland, F. A., Fullerton, N. F. & Heflich, R. H. (1984) Rapid isolation, hydrolysis and chromatography of formaldehyde-modified DNA. J. Chromatogr. 308: 121-131.
8. 1: in vitro effect of vitamins. Mutat. Res. 188: 121-128.
9. Busby, W. F. & Wogan, G. N. (1984) Aflatoxins. In: Chemical Carcinogens (Searle, C. D., ed.), pp. 945-1136. Monograph 182, American Chemical Society, Washington, DC.
10. Casciano, D. A., Chou, M., Lyn-Cook, L. E. & Aidoo, A. (1996) Caloric restriction modulates chemically induced in vivo somatic mutation frequency. Environ. Mol. Mutagen. 27: 162-164.
11. 1-8,9-epoxide. Toxical. Lett. 78: 235-243.
12. Chou, M. W., Kong, J., Chung, K. T. & Hart, R. W. (1993a) Effect of caloric restriction on the metabolic activation of xenobiotics. Mutat. Res. 295: 223-235.
13. Chou, M. W., Wang, B., Von Tungeln, L. S., Beland, F. A. & Fu, P. P. (1987) Induction of rat hepatic cytochromes P-450 by environmental nitropolycyclic aromatic hydrocarbons. Biochem. Pharmacol. 36: 2449-2454.
14. Chou, M. W., Pegram, R. A., Turturro, A., Holson, R. & Hart, R. W. (1993b) Effect of caloric restriction on the induction of hepatic cytochrome P-450 and AH receptor binding in C57BL/6N and DBA/2J mice. Drug Chem. Toxicol. 16: 1-19.
15. 1-DNA formed in vivo in rat liver. Proc. Natl. Acad. Sci. U.S.A. 75: 1745-1749.
16. 1: correlations of patterns of metabolism and DNA modification with biological effects. Basic Life Sci. 24: 49-62.
17. Dunaif, G. E. & Campbell, T. C. (1987) Relative contribution of dietary protein level and aflatoxin B, dose in generation of presumptive preneoplastic foci in rat liver. J. Natl. Cancer Inst. 78: 365-369.
18. Eaton, D. L. & Gallagher, E. P. (1994) Mechanisms of aflatoxin carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 34: 135-172.
19. 1: patterns of DNA adduct formation, removal and excretion in relation to carcinogenesis. Drug Metab. Rev. 13: 581-602.
20. 1: in vitro effect of trace elements. Mutat. Res. 199: 85-93.
21. 1. Toxicol Lett. 61: 233-242.
22. Groopman, J. D., Sabbioni, G. & Wild, C. P. (1991) Molecular dosimetry of aflatoxin exposures. In: Molecular Dosimetry of Human Cancer: Epidemiological, Analytical and Social Considerations (Groopman, J. D. & Skipper, P., eds.), pp. 302-324. CRC Press, Boca Raton, FL.
23. Hoseyni, M. S. (1993) Risk assessment for aflatoxin: III. Modelling the relative risk of hepatocellular carcinoma. Risk Anal. 12: 123-128.
24. Koizumi, A., Weindruch, R. & Walford, R. L. (1987) Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J. Nutr. 117: 361-367.
25. Leakey, J.E.A., Cunny, H. C., Bazare, J., Webb, P. J., Feuers, R. J., Duffy, P. H. & Hart, R. W. (1989) Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system. Mech. Ageing Dev. 48: 145-155.
26. 1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo. Proc. Natl. Acad. Sci. U.S.A. 74: 1870-1874.
27. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
28. Lutz, W. K., Luthy, J. J., Sageisdorff, P. & Schlatter, C. (1980) In vivo covalent binding of aflatoxin B1 and aflatoxin M1 to liver DNA of rat, mouse and pig. Chem-Biol. Interaction 32: 249-256.
29. 1 causes guanine substitution in nucleic acids. Nature (Lond.) 267: 863-865.
30. Newberne, P. M. & Rogers, A. E. (1986) The role of nutrients in cancer causation. In: Nutrition and Cancer (Hayashi, Y., ed.), pp. 205-222. Japan Scientific Press, Tokyo, Japan.
31. Newberne, P. M., Weigert, J. & Kula, N. (1979) Effects of dietary fat on hepatic mixed-function oxidases and hepatocellular carcinoma induced by aflatoxin B1 in rats. Cancer Res. 39: 3986-3991.
32. Pariza, M. W. & Boutwell, R. K. (1987) Historical perspective: caloric and energy expenditure in carcinogenesis. Am. J. Clin. Nutr. 45: 151-156.
33. 3H]7,12-dimethylbenz[a]anthracene to mouse skin DNA. J. Gerontol. 38: 8-12.
34. Pollard, M. & Luckert, P. (1985) Tumorigenesis effects of direct- and indirect-acting chemical carcinogenesis in rats on a restricted diet. J. Natl. Cancer Inst. 74: 1347-1349.
35. 1. Chem. Res. Toxicol. 5: 202-210.
36. Sachan, D. S. & Das, S. K. (1982) Alterations of NADPH-generating and drug-metabolizing enzymes by feed restriction in male rats. J. Nutr. 112: 2301-2306.
37. 7-guanine. Carcinogenesis 11: 519-527.
38. 1-2,3-oxide; evidence for its formation in rat liver in vivo and by human liver microsomes in vitro. Biochem. Biophys. Res. Commun. 60: 1036-1043.
39. Tannenbaum, A. (1942) The genesis and growth of tumors. II. Effects of caloric restriction per se. Cancer Res. 2: 460-467.
40. Witt, W. M., Sheldon, W. G. & Thurman, J. D. (1991) Pathological endpoints in dietary restricted rodents-Fischer 344 rats and B6C3F1 mice. In: Biological Effects of Dietary Restriction (Fishbein, L., ed.), pp. 73-86. Springer-Verlag, Berlin, Germany.
41. Wogan, G. N. (1992) Aflatoxins as risk factors for hepatocellular carcinoma in humans. Cancer Res. (suppl.) 52: 2114-2118.