Testicular Histopathology in Congenital Lipoid Adrenal Hyperplasia: A Light and Electron Microscopic Study

Hormone Research in Paediatrics

Volumn 47, Issue 3, 1997, Pages 121-125

  Aya, Misaki ^a   Ogata, Tsutomu ^a   Sakaguchi, Akira ^a   Sato, Seiji ^a   Matsuo, Nobutake ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cholesterol conversion defect; Congenital lipoid adrenal hyperplasia; Leydig cells; Lipid accumulation

Indexed keywords

CHOLESTEROL; FAT DROPLET; PREGNENOLONE;

ARTICLE; CASE REPORT; CONGENITAL ADRENAL HYPERPLASIA; ELECTRON MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERGONADOTROPIC HYPOGONADISM; INTERSTITIUM; LEYDIG CELL; LIPID STORAGE; MALE; MICROSCOPY; ORCHIECTOMY; PRIORITY JOURNAL; SCHOOL CHILD; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOGONIUM; TESTIS DISEASE;

EID: 0031050124     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000185446     Document Type: Article

References (26)

1. New MI, Levine LS: Congenital Adrenal Hyperplasia. Berlin. Springer, 1984, pp 1-81.
2. Dcgenhart HJ: Prader's syndrome (congenital lipoid adrenal hyperplasia): in New Ml. Levine LS (cds): Adrenal Diseases in Childhood. Pc-diatr Adolesc Endocrinol. Basel. Karger, 1984. vol 13. pp 125-144.
3. Prader A. Gurtner HP: Das Syndrom dcs Pscu-dohcrmaphroditismus masculinusbei kongcni-taler Ncbcnniercnrindcnhypcrplasic ohne An-drogeniiberproduktion (adrenaler Pseudohcr-maphroditismus masculinus). Hclv Pacdialr Acta 1955;10:397-412.
4. Lin D. Sugawara T. Strauss JF. Clark BJ. Stoc-co DM. Saenger P. Rogol A. Miller WL: Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 1995: 267:1828-1831.
5. Tee M-K. Lin D. Sugawara T. Holt JA. Gui-guen Y. Buckingham B. Strauss JF, Miller WL: T A transversion 11 bp from a splice acceptor site in the human gene for steroidogenic acute regulatory protein causes congenital lipoid adrenal hyperplasia. Hum Mol Genet 1995;4:2299-2305.
6. Prader A. Siebenmann RE: Nebenniereninsuf-fizienz bei kongenitaler Lipoidhypcrplasie dcr Nebennieren. Helv Paediatr Acta 1957:12: 569-595.
7. Tsutsui Y, Hirabayashi N, Ito G: An autopsy case of congenital lipoid hyperplasia of the adrenal cortex. Acta Pathol Jpn 1970:20:227-237.
8. Muller J, Torsson A, Nielsen M-D, Peterson KE, Christoffersen J, Skakkebaeck NE: Gonadal development and growth in 46.XX and 46.XY individuals with p450-scc deficiency (congenital lipoid adrenal hyperplasia). Horm Res 1991:36:203-208.
9. Ogata T. Matsuo N. Salto M. Prader A: The testicular lesion and sexual differentiation in congenital lipoid adrenal hyperplasia. Helv Paediatr Acta 1988;43:531-538.
10. Hadziselimovic F: Testis and scrotum: Testicular development: in Gillenwater JY. Gravhack JT. Howards SS. Duckett JW (eds): Adult and Pediatric Urology. St Louis, Mosby, 1987. pp 1932-1947.
11. Paniagua R, Nistal M: Morphological and his-lometric study of human spermatogonia from birth to the onset of puberty. J Anat 1984:139: 535-552.
12. Hadziselimovic F: Histology and ultrastructure of normal and cryptorchid testes: in Hadziselimovic F (ed): Cryptorchidism: Management and Implications. Berlin. Springer. 1983, pp 35-58.
13. Hcdinger CE: Histopathology of undesccndcd testes. Eur J Pediatr 1982:139:266-271.
14. Hadziselimovic F: Endocrinology of the hypo-thalamo-pituitarv-gonadal axis; in Hadziselimovic F (ed): Cryptorchidism: Management and Implications. Berlin. Springer. 1983. pp 59-70.
15. Canlorbe P. Toublanc JE. Roger M. Job JC: Etude de la fonction endocrine dans 125 cas de cryptorchidics. Ann Med Interne 1974:125: 365-369.
16. 5-3p-hvdroxyste-roid dehydrogenase activities in rat testes. Steroids 1978:31:189-203.
17. Chcmcs HE. Rivarola MA. Bergada C: Effect of hCG on the interstitial cells and androgen production in immature rat testis. J Reprod Fertil 1976:46:279-282.
18. Christiansen AK. Peacock K: Increase in Lcy-dig cell number in testes of adult rats treated chronically with an excess of human chorionic gonadotropin. Biol Reprod 1980:22:383-391.
19. Ketclslegers JM. Ilctzel WD. Sherins RJ. Catt KJ: Developmental changes in testicular gonadotropin receptors: Plasma gonadotropins and plasma testosterone in the rat. Endocrinology 1978;103:212-222.
20. Mancini RE. Castro A. Seigur AC: Histologic localization of follicle-stimulating and luteinizing hormones in the rat testis. J Histochcm Cytochem 1967:15:516-525.
21. Orth J. Christensen K: Localization of l25I-labeled FSH in the testes of hypophysecto-mized rats by autoradiography at the light and electron microscope levels. Endocrinology 1977:101:262-278.
22. Means AR: Male reproductive system: Biological effects of follicle-stimulating hormone on the testis; in Hamilton DW. Grcep RO (eds): Endocrinology. Washington. American Physiological Society. 1975, pp 203-218.
23. Alphen MMA, Kant HJG, Rooij DG: Follicle-stimulating hormone stimulates spermatogenesis in the adult monkey. Endocrinology 1977: 101:262-278.
24. Murphy HD: Sertoli cell stimulation following intratesticular injections of FSH in the hvpoph-ysectomized rat. Proc Soc Exp Biol Med 1965: 118:1202-1205.
25. Means AR. Fakunding JL. Huckins C. Tindall DJ. Vitale R: Follicle-stimulating hormone, the Sertoli cell, and spermatogenesis. Recent Prog Horn Res 1976:32:477-527.
26. Schindler AM. Diaz P. Cuendct A. Shizoncnko PC: Cryptorchidism: A morphological study of 670 biopsies. Helv Paediatr Acta 1987:42:145-158.