Epidural metabolism of articaine to its metabolite articainic acid in five patients after epidural administration of 600 mg articaine

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 2, 1997, Pages 158-163

  Vree, Tom B ^a   Van Oss, Gertjan E C J M ^b   Gielen, Mathieu J M ^b   Booij, Leo H D J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RIJNSTATE HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICAINE; ARTICAINIC ACID; LOCAL ANESTHETIC AGENT;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; EPIDURAL ANESTHESIA; EPIDURAL DRUG ADMINISTRATION; FEMALE; HUMAN; MALE; URINARY EXCRETION;

EID: 0031050043     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06772.x     Document Type: Article

References (21)

1. Akerman, B., Aström, A., Ross, S., Telc, A. (1966) Studies on absorption, distribution and metabolism of labelled prilocaine and lidocaine in some animal species. Acta Pharmacol. Toxicol. 24: 389-395
2. Brinklov, M. M. (1977) Effectivity of carticaine, a new local anesthetic. A survey and a double blind investigation comparing carticaine with lidocaine in epidural analgesia. Acta Anaesth. Scand. 21: 5-16
3. Ferger, P., Marxkors, K. (1973) Ein neues Anästhetikum in der Zahnärztlichen Prosthetik. Dtsch. Zahnarztl. Z. 28: 87
4. Hendolin, H., Mattila, M. (1974) Hoe 40045, ein neues Lokalanästhetikum verglichen mit Lidocain bei Epiduralanästhesie. Prakt. Anästh. 9: 178-182
5. Kirch, W., Kitteringham, N., Lambers, G., Hajdu, P., Ohnhaus, E. E. (1983) Die klinische Pharmacokinetik von Articain nach intraoraler und intramuskulärer Applikation. Schweiz. Mschr. Zahnheilk. 93: 714-719
6. Koopman-Kimenai, P. M., Vree, T. B., Hasenbos, M. A. W. M., Weber, E. W. G., Verweij-van Wissen, C. P. W. G. M., Booij, L. H. D. J. (1991) Pharmacokinetics of nicomorphine and its metabolites in man after epidural administration. Pharm. Weekbl. Sci. 13: 142-147
7. Koopman-Kimenai, P. M., Vree, T. B., Booij, L. H. D. J., Hasenbos, M. A. W. M. (1995) Pharmacokinetics of epidurally administered nicomorphine with its metabolites and glucuronide conjugates in patients undergoing pulmonary surgery during combined epidural local anaesthetic block and general anaesthesia. Biopharm. Drug Dispos. 16: 507-520
8. Moller, R. A., Covino, B. G. (1993) Cardiac electrophysiologic effects of articaine compared with bupivacaine and lidocaine. Anesth. Analg. 76: 1266-1273
9. Muschawek, R., Rippel, R. (1974) Ein neuwe Lokalanästhetikum (Carticain) aus der Thiophenreihe. Prakt. Anästh. 9: 135-140
10. Proost, J. H., Meijer, D. K. W. (1992) MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring. Comput. Biol. Med. 22: 155-163
11. Simon, M. A. M., Gielen, M. J. M., Alberink, N., Vree, T. B., van Egmond, J. (1996) Intravenous regional anesthesia with 0-5% articaine, 0-5% lidocaine or 0-5% prilocaine. A double blind randomized study. Regional Anesthesia. In press
12. van Oss, G. E. C. J. M., Vree, T. B., Baars, A. M., Termond, E. F. S., Booij, L. H. D. J. (1988a) Klinische effecten en farmacokinetiek van een intraveneuze toediening van articainezuur in een vrijwilliger (Clinical effects and pharmacokinetics of iv articainic acid in a subject). Ned. Tschrft. Anesthesiol. 1: 21-25
13. van Oss, G. E. C. J. M., Vree, T. B., Baars, A. M., Termond, E. F. S., Booij, L. H. D. J. (1988b) Clinical effects and pharmacokinetics of articainic acid in one volunteer after intravenous administration. Pharm. Weekbl. Sci. 10: 284-287
14. van Oss, G. E. C. J. M., Vree, T. B., Baars, A. M., Termond, E. F. S., Booij, L. H. D. J. (1989) Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration. Eur. J. Anaesthesiol. 6: 49-56
15. Vree, T. B., Baars, A. M., van Oss, G. E. C. J. M., Booij, L. H. D. J. (1988) High-performance liquid chromatography and preliminary pharmacokinetics of articaine and its 2-carboxy metabolite in humans in serum and urine. J. Chromatogr. 424: 440-444
16. 1-glucuronidation and N4-acetylation of sulfadimethoxine in man. Pharm. Weekbl. Sci. 12: 51-60
17. 4-acetyl metabolites in plasma and urine of man. Pharm. Weekbl. Sci. 12: 243-247
18. Vree, T. B., van Ewijk-Beneken Kolmer, E. W. J., Wuis, E. W., Hekster, Y. A. (1992) Capacity-limited renal glucuronidation of probenecid by humans. Pharm. Weekbl. Sci. 14: 325-331
19. Vree, T. B., van den Biggelaar-Martea M., Verwey-van Wissen, C.P.W.G.M., van Ewijk-Beneken Kolmer, E.W.J. (1994) Probenecid inhibits the glucuronidation of indomethacin and O-desmethylindomethacin in humans. A pilot experiment. Pharm. World Sci. 16: 22-27
20. Vree, T. B., van den Biggelaar-Martea, M., Verwey-van Wissen, C. P. W. G. M. (1995a) Probenecid inhibits the renal clearance of frusemide and its acyl glucuronide. Br. J. Clin. Pharmacol. 39: 692-695
21. Vree, T. B., van den Biggelaar-Martea, M., Verwey-van Wissen, C. P. W. G. M. (1995b) Frusemide and its acyl glucuronide show a short and long phase in elimination kinetics and pharmacodynamic effect in man. J. Pharm. Pharmacol. 47: 964-969