A critical review of genetic studies of schizophrenia. II. Molecular genetic studies

Acta Psychiatrica Scandinavica

Volumn 95, Issue 2, 1997, Pages 73-80

  Portin, P ^a   Alanen, Y O ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Chromosome; Dopamine receptor; Gene; Linkage; Locus; Schizophrenia

Indexed keywords

HUMAN; MOLECULAR GENETICS; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA;

EID: 0031049348     PISSN: 0001690X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0447.1997.tb00377.x     Document Type: Review

References (128)

1. BASSETT A, MCGILLIVRAY BC, JONES BD, PANTZAR JT. Partial trisomy chromosome 5 co-segregating with schizophrenia. Lancet 1988: i: 799-801.
2. SHERRINGTON R, BRYNJOLFSSON J, PERTUSSON H et al. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 1988: 336: 164-167.
3. KENNEDY JL, GIUFFRA LA, MOISES HW et al. Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 1988: 336: 167-170.
4. KAUFMAN CA, DELISE E, LEHNER T, GILLIAN TC. Physical mapping, linkage analysis of the putative schizophrenia locus on chromosome 5q. Schizophr Bull 1989: 15: 441-452.
5. MCGUFFIN P, SARGEANT M, HETTI G, TIDMARSH S WHATLEY S, MARCHBANKS RM. Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region. New data and a reanalysis of previous reports. Am J Hum Genet 1990: 47: 524-535.
6. ASCHAUER HN, ASCHAUER-TRIEBER G, ISENBERG KE et al. No evidence for linkage between chromosome 5 markers and schizophrenia. Hum Hered 1990: 40: 109-115.
7. ST CLAIR D, BLACKWOOD D, MUIR W et al. No linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families. Nature 1989: 339: 305-309.
8. DATERA-WADLEIGH SD, GOLDIN LR, SHERRINGTON R et al. Exclusion of linkage to 5q11-13 in families with schizophrenia and other psychiatric disorders. Nature 1989: 340: 391-393.
9. GENEST P, DUMAS L, GENEST FB. Translocation chromosomique t(2;18)(q21:q23) chez un individu schizophrène et sa fille. Union Med Canad 1976: 105: 1676-1681.
10. ASCHAUER HN, FISHER G, ISENBERG KE et al. No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region. Eur Arch Psychiatr Clin Neurosci 1993: 243: 193-198.
11. GILL M, MCGUFFIN P, PARFITT E et al. A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11 Psychol Med 1993: 23: 27-44.
12. CROW TJ. Sex chromosomes and psychosis. The case for a pseudoautosomal locus. Br J Psychiatry 1988: 153: 675-683.
13. CROW TJ, DELISI LE, JOHNSTONE EC. Concordance by sex in sibling pairs with schizophrenia is paternally inherited: evidence for a pseudoautosomal locus. Br J Psychiatry 1989: 155: 92-97.
14. ISHIDA T, YONEDA H, SAKAI T et al. Pseudoautosomal region in schizophrenia: sex concordance of the affected sib pairs and the association study of eight DNA markers. Am J Med Genet 1993: 48: 151-155.
15. DELISI LE, DEVETO M, LOFTHOUSE R et al. Search for linkage to schizophrenia on the X and Y chromosomes. Am J Med Genet 1994: 54: 113-121.
16. CARLSSON A, LINDQVIST M. Effect of chlorpromazine and haloperidol on formation of methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol 1963: 20: 140-144.
17. VAN ROSSUM JM. The significance of dopamine-receptor blockade for the action of neuroleptic drugs. In: BILL H et al., ed. Neuropsychopharmacology. Amsterdam: Excerpta Medica Foundation, 1967: 321-329.
18. MATTHYSSE S. Antipsychotic drug actions: a clue to the neuropathology of schizophrenia? Fed Proc 1973: 32: 200-205.
19. SNYDER SH. Dopamine receptors, neuroleptics, and schizophrenia. Am J Psychiatry 1981: 138: 460-464.
20. SEEMAN P. Schizophrenia as a brain disease: the dopamine receptor story. Arch Neurology 1993: 50: 1093-1095.
21. SEEMAN P. Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1987: 1: 133-152.
22. SEEMAN P, VAN TOL HHM. Dopamine receptor pharmacology. Curr Opin Neurol Neurosurg 1993: 6: 602-608.
23. SANDER T, SCHMIDT LG. Molecular biological perspectives in treating neuropsychiatric disorders with dopamine drugs. Pharmacopsychiatry 1994: 27 (Suppl. 1): 11-14.
24. CROW TJ, HARRINGTON CA. Etiopathogenesis and treatment of psychosis. Annu Rev Med 1994: 45: 219-234.
25. CIVELLI O, BUNZOW JR, GRANDY DK et al. Molecular biology of dopamine receptors. Eur J Pharmacol 1991: 207: 277-286.
26. LEE T, SEEMAN P. Elevation of brain neuroleptics/dopamine receptors in schizophrenia. Am J Psychiatry 1980: 137: 191-197.
27. MACKAY AVP, IVERSEN LL, ROSSOR M et al. Increased brain dopamine receptors in schizophrenia. Arch Gen Psychiatry 1982: 39: 991-997.
28. 4 receptors elevated in schizophrenia. Nature 1993: 365: 441-445.
29. 4 dopamine receptors in post-mortem striatum from patients with schizophrenia. J Neurosci 1995: 15: 2186-2191.
30. 11C] raclopride. Arch Gen Psychiatry 1990: 47: 213-219.
31. 76Br] bromospiperone in untreated schizophrenic patients. Am J Psychiatry 1990: 147: 44-50.
32. HIETALA J, SYVÄLAHTI E, VUORIO K et al. Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients. Lancet 1995: 346: 1130-1131.
33. 4 receptor variants in the human population. Nature 1992: 358: 149-152.
34. 4-receptor variants in unrelated schizophrenic cases and controls. Am J Med Genet 1993: 48: 90-93.
35. 4-receptor gene shows no evidence of association with schizophrenia. Am J Med Genet 1994: 54: 256-258.
36. 1 dopamine receptor gene and several flanking DNA markers. Hum Hered 1993: 43: 58-62.
37. 2 dopamine receptor. In: New Research Abstracts. Annual Meeting of American Psychiatric Association, San Francisco, 1989: 50.
38. GERSHON ES, RIEDER MO. Major disorders of mind and brain. Sci Am 1992: 267: 89-95.
39. 2 receptor gene and schizophrenia. Psychiatr Res 1994: 53: 203-215.
40. 2 dopamine receptor gene region and schizophrenia. Arch Gen Psychiatry 1991: 48: 643-647.
41. 2 dopamine receptor gene region of chromosome 11q in 112 Irish multiplex families. Arch Gen Psychiatry 1993: 50: 205-211.
42. WANG ZW, BLACK D, ANDREASEN NC, CROWE RR. A linkage study of chromosome 11q in schizophrenia. Arch Gen Psychiatry 1993: 50: 212-216.
43. 3 receptor gene. J Med Genet 1992: 29: 858-860.
44. 3 receptor gene and schizophrenia. Am J Med Genet 1994: 54: 21-26.
45. 3 receptor gene polymorphism: probable effects of family history of schizophrenia. Am J Med Genet 1993: 48: 214-217.
46. 3 receptor gene. J Med Genet 1993: 30: 708-709.
47. 3 receptor polymorphism. Hum Psychopharmacol 1995: 10: 19-24.
48. 3 receptor gene. Acta Psychiatr Scand 1993: 87: 345-349.
49. 3 receptor gene. Hum Genet 1993: 92: 336-338.
50. 3 receptor gene in schizophrenia not confirmed. J Med Genet 1993: 30: 708.
51. 3 receptor gene and schizophrenia. Am J Psychiatry 1994: 151: 107-111.
52. 3 dopamine receptor gene. Am J Med Genet 1993: 48: 83-86.
53. 3 receptor locus. Am J Med Genet 1994: 54: 264-267.
54. 3 dopamine receptor gene locus in Icelandic pedigrees. Psychiatr Res 1993: 46: 69-78.
55. GERSHON ES, RIEDER RO. Major disorders of mind and brain. Sci Am 1992: 267: 89-95.
56. 4 dopamine receptor gene variant in an Italian schizophrenic kindred. Arch Gen Psychiatry 1994: 51: 288-293.
57. 4 receptor gene. Psychiatr Res 1994: 53: 77-86.
58. 4 receptor gene and schizophrenia. Am J Med Genet 1994: 54: 8-11.
59. 4 receptor gene in psychotic patients. Biol Psychiatry 1993: 34: 459-464.
60. COON H, BYERLEY W, HOLIK J et al. Linkage analysis in schizophrenia with five dopamine receptor genes in nine pedigrees. Am J Hum Genet 1993: 52: 327-334.
61. SUNAHARA RK, SEEMAN P, VAN TOL HHM, NIZNIK HB. Dopamine receptors and antipsychotic drug response. Br J Psychiatry 1993: 163 (Suppl. 22): 31-38.
62. 2 receptor gene in schizophrenic and delusional patients. Neuropsychobiology 1992: 26: 1-3.
63. 2 receptor gene in alcoholism or schizophrenia: analysis using denaturing gradient gel electrophroresis. J Am Med Assoc 1994: 271: 204-208.
64. 311→Cys). Biochem Biophys Res Commun 1993: 196: 1369-1375.
65. 2 receptor molecular variant with schizophrenia. Lancet 1994: 343: 703-704.
66. NANKO S, HATTORI M, DAI XY, FUKUDA R, KAZAMATSURI H. DRD2 Ser 311/Cys 311 polymorphism in schizophrenia. Lancet 1994: 343: 1044.
67. HATTORI M, NANKO S, DAI XY, FUKUDA R, KAZAMATSURI M. Mismatch PCR RFLP detection of DRD2 SER311CYS polymorphism and schizophrenia. Biochem Biophys Res Commun 1994: 202: 757-763.
68. BYERLEY W, COON H, HOFF M et al. Human dopamine transporter gene not linked to schizophrenia in multi-generational pedigrees. Hum Hered 1993: 43: 319-322.
69. LI T, YANG L, WIESE C et al. No association between alleles or genotypes at the dopamine transporter gene and schizophrenia. Psychiatr Res 1994: 52: 17-23.
70. 1 receptor gene in 131 schizophrenics and eight alcoholics: identification of polymorphism but lack of functionally significant sequence changes. Am J Med Genet 1995: 60: 165-171.
71. 5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. Hum Mol Genet 1995: 4: 507-514.
72. 2 receptor (DRD2) and chromosome 11q translocation sites. Psychol Med 1995: 25: 531-537.
73. ASHERSON P, MANT R, SARGEANT M et al. Exclusion of close linkage between GABA-A receptor subunit 1A gene and schizophrenia using a microsatellite repeat marker. 23rd Annual Symposium of the European Society of Human Genetics, Leuven, Belgium, 13-16 July. Clin Genet 1991: 40: 400.
74. A receptor subunit gene in patients with schizophrenia. Am J Med Genet 1993: 54: 12-20.
75. NANKO S, HATTORI M, KUWATA S et al. Neurotrophin-3 gene polymorphism associated with schizophrenia. Acta Psychiatr Scand 1994: 89: 390-392.
76. ST CLAIR D. Expanded CAG trinucleotide repeat of Huntington's disease gene in a patient with schizophrenia and normal striatal histology. J Med Genet 1994: 31: 658-659.
77. RUBINSZTEIN DC, LEGGO J, GOODBURN S et al. Study of the Huntington's disease (HD) gene CAG repeats in schizophrenic patients shows overlap of the normal and HD-affected ranges but absence of correlation with schizophrenia. J Med Genet 1994: 31: 690-693.
78. SANDERS AR, RINCON-LIMAS DE, CHAKRABORTY R et al. Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia. Schizophr Res 1992: 8: 211-221.
79. OWEN MJ, MANT R, PARFITT E et al. No association between RFLPs at the porphobilinogen deaminase gene and schizophrenia. Hum Genet 1992: 90: 131-132.
80. NIMGAONKAR VL, GANGULI R, WASHINGTON SS, CHAKRAVARTI A. Schizophrenia and porphobilinogen deaminase gene polymorphism: an association study. Schizophr Res 1992: 8: 51-58.
81. BYERLEY W, PLAETKE R, HOFF M et al. Tyrosine hydroxylase gene not linked to schizophrenia in 9 pedigrees. Psychiatr Genet 1993: 3: 29-31.
82. PULVER AE, KARAYIORGOU M, WOLYNIEC PS et al. Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1. Part 1. Am J Med Genet 1994: 54: 36-43.
83. PULVER AE, KARAYIORGOU M, LASSETER VK et al. Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1. Part 2. Am J Med Genet 1994: 54: 44-50.
84. COON H, HOLIK J, HOFF M et al. Analysis of chromosome 22 markers in nine schizophrenic pedigrees. Am J Med Genet 1994: 54: 72-79.
85. ICHINOSE H, OHYE T, FUJITA K et al. Quantification of mRNA of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in the substantia nigra in Parkinson's disease and schizophrenia. J Neural Transm (Parkinson's Dis Dem Sect) 1995: 8: 149-158.
86. MELONI R, LAURENT C, CAMPION D et al. A rare allele of a microsatellite located in the tyrosine hydroxylase gene found in schizophrenia patients. Comp Rend Acad Sci Ser III - Sci La Vie - Life Sci 1995: 318: 803-809.
87. HOVATTA I, SEPPÄLÄ J, PEKKARINEN P, TANSKANEN A, LÖNNQVIST J, PELTONEN L. Linkage analysis in two schizophrenic families originating from a restricted subpopulation in Finland. Psychiatr Genet 1994: 4: 143-152.
88. KARAYIORGOU M, KASCH L, LASSETER VK et al. Report from the Maryland epidemiology schizophrenia linkage study: no evidence for linkage between schizophrenia and a number of candidate and other genomic regions using a complex dominant model. Am J Med Genet 1994: 54: 345-353.
89. MCGUFFIN P, STURT E. Genetic markers in schizophrenia. Hum Hered 1986: 36: 65-88.
90. OWEN MJ, MCGUFFIN P. DNA and classical genetic markers in schizophrenia. Eur Arch Psychiatr Clin Neurosci 1991: 240: 197-203.
91. WANG S, SUN C, WALCZAK CA et al. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nature Genet 1995: 10: 41-46.
92. STRAUB RE, MACLEAN CJ, O'NEILL A et al. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nature Genet 1995: 11: 267-293.
93. MOWRY BJ, NANCARROW DJ, LENNON DP et al. Schizophrenia susceptibility and chromosome 6p24-22. Nature Genet 1995: 11: 233-234.
94. GURLING H, KALSI G, HUI-SUI CHEN A et al. Schizophrenia susceptibility and chromosome 6p24-22. Nature Genet 1995: 11: 234-235.
95. ANTONARAKIS SE, BLOUIN J-E, PULVER AE et al. Schizophrenia susceptibility and chromosome 6p24-22. Nature Genet 1995: 11: 235-236.
96. SCHWAB SG, ALBUS M, HALLMAYER J et al. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nature Genet 1995: 11: 325-327.
97. COON H, JENSEN S, HOLIK J et al. Genomic scan for genes pre-disposing to schizophrenia. Am J Med Genet 1994: 54: 59-71.
98. BARR CL, KENNEDY JL, PAKSTIS AJ et al. Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred. Am J Med Genet 1994: 54: 51-58.
99. MURRAY JC, BUETOW KH, WEBER JL et al. A comprehensive human linkage map with centimorgan density. Science 1994: 265: 2049-2054.
100. KENNEDY JL, GIUFFRA LA, MOISES HW et al. Molecular genetic studies in schizophrenia. Schizophr Bull 1989: 15: 383-391.
101. POLYMEROPOULOS MH, COON H, BYERLEY W et al. Search for a schizophrenia susceptibility locus on human chromosome 22. Am J Med Genet 1994: 54: 93-99.
102. VALLADA HP, GILL M, SHAM P et al. Linkage studies on chromosome 22 in familial schizophrenia. Am J Med Genet 1995: 60: 139-146.
103. KARAYIORGOU M, MORRIS MA, MORROW B et al. Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc Natl Acad Sci USA 1995: 92: 7612-7616.
104. PROPPING P, NÖTHEN MM. Schizophrenia: genetic tools for unraveling the nature of a complex disorder. Proc Natl Acad Sci USA 1995: 92: 7607-7608.
105. NANKO S, FUKUDA R, HATTORI M et al. No evidence of linkage or allelic association of schizophrenia with DNA markers at pericentric region of chromosome 9. Biol Psychiatry 1994: 36: 589-594.
106. BYERLEY W, HOFF M, HOLIK J et al. Linkage analysis between schizophrenia and index simple-sequence repeat loci for chromosome 21. Hum Hered 1995: 45: 49-52.
107. MOISES HW, YANG L, KRISTBJARNASON H et al. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genet 1995: 11: 321-324.
108. COMMENGES D, OLSON J, WIJSMAN E. The weighted rank pairwise correlation statistic for linkage analysis: simulation study and application to Alzheimer's disease. Genet Epidemiol 1994: 11: 201-212.
109. MCGUE M, GOTTESMAN II, RAO DC. Resolving genetic models for the transmission of schizophrenia. Genet Epidemiol 1985: 2: 99-110.
110. MCGUFFIN P, STURT E. Genetic markers in schizophrenia. Hum Hered 1986: 36: 65-88.
111. MCGUE M, GOTTESMAN II. Genetic linkage in schizophrenia: perspectives from genetic epidemiology. Schizophr Bull 1989: 15: 453-463.
112. KRINGLEN E. Genetic aspects of schizophrenia with special emphasis on twin research. In: KRINGLEN E et al., ed. Etiology of mental disorders. Oslo: Department of Psychiatry, University of Oslo, 1990: 63-79.
113. OWEN MJ, MCGUFFIN P. Association and linkage: complementary strategies for complex disorders. J Med Genet 1993: 30: 638-639.
114. TIENARI P, SORRI A, LAHTI I et al. Genetic and psychosocial factors in schizophrenia: the Finnish adoptive family study. Schizophr Bull 1987: 13: 477-484.
115. TIENARI P. Genes, family environment or interaction. Findings from an adoption study. In: KRINGLEN E et al., ed. Etiology of mental disorders. Oslo: Department of Psychiatry, University of Oslo, 1991: 33-48.
116. TIENARI P, WYNNE LC, MORING J et al. Genetic vulnerability or family environment? Implications from Finnish adoptive family study of schizophrenia. Psychiatr Fenn 1993: 24: 23-41.
117. WAHLBERG K-E. Parental communication and thought disorders of the offspring. An adoptive study (in Finnish, with English abstract and summary). Acta Universitatis Ouluensis, Series D Medica 305, Oulu, 1994: 1-172.
118. CLONINGER CR. Turning point in the design of linkage studies of schizophrenia. Am J Med Genet 1994: 54: 83-92.
119. KENDLER KS, EAVES LJ. Models for the joint effect of genotype and environment on liability to psychiatric illness. Am J Psychiatry 1986: 143: 279-289.
120. CHEN WJ, FARAONE SV, TSUANG MT. Linkage studies in schizophrenia: a simulation study of statistical power. Genet Epidemiol 1992: 9: 123-139.
121. LANDER E, KRUGLYAK L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 1995: 11: 241-247.
122. BOEHNKE M. Limits of resolution of genetic linkage studies: implications for the positional cloning of human disease genes. Am J Hum Genet 1994: 55: 379-390.
123. CARDNO AG, MCGUFFIN P. The molecular genetics of schizophrenia. Neuropath Appl Neurobiol 1994: 29: 344-349.
124. RUTTER M. Psychiatric genetics: research challenges and pathways forward. Am J Med Genet 1994: 54: 185-198.
125. BARON M. Genes and psychosis: old wine in new bottles? Acta Psychiatr Scand 1995: 92: 81-86.
126. STURT E, MCGUFFIN P. Can linkage and marker association resolve the genetic etiology of psychiatric disorders? Review and argument. Psychol Med 1985: 15: 455-462.
127. OWEN MJ. Will schizophrenia become a graveyard for molecular genetics? Psychol Med 1992: 22: 289-293.
128. ALANEN YO. Schizophrenia - its origins and need-adapted treatment (in Finnish; to be published in English), Porvoo, Helsinki, Juva: Werner Söderström OY, 1993.