Effect of nicotine on large bowel mucus thickness, eicosanoids and faecal proteinase in ferrets

European Journal of Gastroenterology and Hepatology

Volumn 9, Issue 2, 1997, Pages 179-182

  Thomas, Gareth A O ^a   Pullan, Rupert D ^b   Zijlstra, Freek J ^c   Rankin, Ben J ^d   Russell, Michael A H ^e   Feyerabend, Colin ^e   Allen, Adrian ^d   Rhodes, John ^a  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b TORBAY HOSPITAL   (United Kingdom)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Eicosanoids; Faecal proteinase; Mucus thickness; Nicotine

Indexed keywords

COTININE; ICOSANOID; NICOTINE; PROTEINASE;

ANIMAL EXPERIMENT; ARTICLE; DRUG BLOOD LEVEL; FECES LEVEL; FERRET; LARGE INTESTINE; MALE; MUCUS; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; RABBIT; SMOKING; SUBCUTANEOUS DRUG ADMINISTRATION; THICKNESS;

EID: 0031048832     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199702000-00013     Document Type: Article

References (10)

1. Calkins BM: A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 1989, 34:1841-1854.
2. Pullan RD, Rhodes J, Ganesh S, et al.: Transdermal nicotine for active ulcerative colitis. N Engl J Med 1994, 330:811-815.
3. Thomas GAO, Rhodes J, Mani V, et al.: Transdermal nicotine as maintenance therapy for ulcerative colitis. N Engt J Med 1995, 332:988-992.
4. Zijlstra FJ, Srivastava ED, Rhodes M, et al.: Effect of nicotine on rectal mucus and mucosal eicosanoids. Gut 1994, 35:247-251.
5. Kerss S, Allen A, Garner A: A simple method for measuring thickness of the mucosa gel layer adherent to rat, frog and human gastric mucosa: influence of feeding, prostaglandin, N-acetylcysteine and other agents. Clin Sci 1982, 63:187-195.
6. Pullan RD, Thomas GAO, Rhodes M, et al.: Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut 1994, 35:353-359.
7. Van der Ham AC, Kort WJ, Beijma AM, et al.: Eicosanoid profile of healing colon anastomosis and peritoneal macrophages in the rat. Gut 1990, 30:807-811.
8. Zijlstra FJ, Wilson JHP: 15-HETE is the main eicosanoid present in mucus of ulcerative colitis. Prostaglandins Leukot Essent Fatty Acids 1991, 43:55-59.
9. Hutton DA, Pearson JP, Allan A, Foster SNE: Mucolysis of the colonic mucus barrier by faecal proteinases: inhibition by interacting polyacrylate. Clin Sci 1990, 78:265-271.
10. Feyerabend C, Russell MAH: A rapid gas-liquid chromatographic method for the determination of nicotine and cotinine in biological fluids. J Pharm Pharmacol 1990, 42:420-452.