Controlled trial of 4-ASA in ulcerative colitis

Digestive Diseases and Sciences

Volumn 42, Issue 2, 1997, Pages 354-358

  Beeken, W ^a   Howard, D ^b   Bigelow, J ^b   Trainer, T ^b   Roy, M ^b   Thayer, W ^b   Wild, G ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b NONE

Author keywords

4 aminosalicylic acid; controlled trial; treatment; ulcerative colitis

Indexed keywords

AMINOSALICYLIC ACID; PLACEBO;

ADULT; ARTICLE; BIOPSY; BLEEDING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SIGMOIDOSCOPY; ULCERATIVE COLITIS;

BIOPSY; COLITIS, ULCERATIVE; FECES; FEMALE; HUMANS; MALE; MIDDLE AGED; P-AMINOSALICYLIC ACID; RECTUM;

EID: 0031048821     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018874120749     Document Type: Article

References (14)

1. Peskar BM, Coersmeier CH: Effect of antiinflammatory drugs on human colonic leukotriene formation. In Inflammatory Bowel Diseases, Basic Research and Clinical Implications. H Goebell, BM Peskar, H Malchow (eds). Boston, MTP Press, 1988, pp 153-159
2. 2) inhibition by sulfasalazine (SAZ) and aminosalicylates: Extra- vs intracellular action. Gastroenterology 100:A556, 1991
3. Selby WS, Bennett MK, Jewell DP: Topical treatment of distal ulcerative colitis with 4-aminosalicylic acid enemas. Digestion 29:231-234, 1984
4. Ginsberg AL, Beck LS, McIntosh TM, Nochomovitz LE: Treatment of left-sided ulcerative colitis with 4-aminosalicylic acid enemas. A double-blind placebo-controlled trial. Ann Intern Med 108:195-199, 1988
5. Gandolfo J, Farthing M, Powers G, Eagen K, Goldberg M, Berman P, Kaplan M: 4-Aminosalicylic acid retention enemas in treatment of distal colitis. Dig Dis Sci 32:700-704, 1987
6. Campieri M, Lanfranchi GA, Bertoni F, Brignola AC, Bazzocchi G, Minguzzi MR, Labo G: A double-blind clinical trial to compare the effects of 4-aminosalicylic acid to 5-aminosalicylic in topical treatment of ulcerative colitis. Digestion 29:204-208, 1984
7. Nagy F, Karacsony G, Varro V: Experience with topical administration of 4-aminosalicylic acid in ulcerative colitis. Dis Colon Rectum 32:134-137, 1989
8. O'Donnell LJD, Arvind AS, Cameron D, Hoang P, Talbot IC, Jewell DP, Lennard-Jones JE, Farthing MJG: 4-Aminosalicylic acid enemas are as effective as prednisolone enemas in distal ulcerative colitis. Gastroenterology 98:A195, 1990
9. Ginsberg AL, Davis ND, Nochamovitz LE: Placebo-controlled, double-blind trial of oral 4-aminosalicylic acid in ulcerative colitis. Gastroenterology 98:A172, 1990
10. Nasr B, Bigelow J, Roff N, Beeken W: Luminal concentrations of orally ingested 4-ASA as determined by in vivo equilibrium dialysis. Aliment Pharmacol Ther 4:583-592, 1990
11. Schroeder KW, Tremaine WJ, Ilstrup DM: Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med 317:1625-1629, 1987
12. Lauritsen K, Hansen J, Ryde M, Rask-Madsen J: Colonic azodisalicylate metabolism determined by in vivo dialysis in healthy volunteers and patients with ulcerative colitis. Gastroenterology 86:1496-1500, 1984
13. Willoughby CP, Piris J, Truelove SC: The effect of topical N-acctyl 5-aminosalicylic acid in ulcerative colitis. Scand J Gastroenterol 15:715-719, 1980
14. Binder V, Halskov S, Hvidherg E, Aristensen E, Riis P, Tougaard L, Willumsen L: A controlled study of 5-acetaminosalicylic acid (5-AC-ASA) as enema in ulcerative colitis. Scand J Gastroenterol 16:1122, 1981 (abstract)