Loss of heterozygosity at chromosome 7q in human breast cancer: Association with clinical variables

Anticancer Research

Volumn 17, Issue 1 A, 1997, Pages 93-98

  Kristjansson, Arni Kjalar ^a   Eiriksdottir, Gudny ^a   Ragnarsson, Gisli ^a   Sigurdsson, Asgeir ^a   Gudmundsson, Julius ^a   Barkardottir, Rosa Bjork ^a   Jonasson, Jon G ^a   Egilsson, Valgardur ^a   Ingvarsson, Sigurdur ^a  

^a LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

Breast cancer; Chromosome 7q; Clinicopathology; Loss of heterozygosity,; Tumor suppressor genes

Indexed keywords

DNA MARKER; MICROSATELLITE DNA; STEROID RECEPTOR;

ADULT; ARTICLE; BREAST CANCER; CANCER SURVIVAL; CELL CYCLE S PHASE; CHROMOSOME 13Q; CHROMOSOME 17Q; CHROMOSOME 1P; CHROMOSOME 3P; CHROMOSOME 7Q; CHROMOSOME 9P; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE DELETION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PLOIDY; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

BREAST NEOPLASMS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 7; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; MIDDLE AGED;

EID: 0031048452     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. McPherson K, Steel CM, Dixon JM: ABC of breast diseases. Breast cancer-epidemiology, risk factors and genetics. BMJ 309(6960): 1003-1006, 1994.
2. El-Ashry D, Lippman ME: Molecular biology of breast carcinoma. World J Surg 18: 12-20, 1994.
3. McGuire WL, Clark GM: Prognostic factors and treatment decisions in axillary-node negative breast cancer. N Engl J Med 326: 1756-1761, 1992.
4. Callahan R, Cropp C, Merlo GR, Diella F, Venesio T, Lidereau R, Cappa APM, Lisicia DS: Genetic and molecular heterogeneity of breast cancer cells. Clin Chim Acta 217: 63-73, 1993.
5. Devilee P, Cornelisse CJ: Somatic genetic changes in human breast cancer. Biochim Biophys Acta 1198: 113-130, 1994.
6. Iurlo A, Mecucci C, Orshoven AV, Michaux JL, Boogaerts M, Noens L, Bosly A, Louwagie A, Berghe HVD: Cytogenetic and clinical investigations in 76 cases with therapy related leukemia and myelodysplastic syndrome. Cancer Genet Cytogenet 43: 227-41, 1989.
7. Mamuris Z, Dumont J, Dutrillaux B, Aurias A: Chromosomal differences between acute nonlymphocytic leukemia in patients with prior solid tumors and prior hematologic malignancies. A study of 14 cases with prior breast cancer. Cancer Genet Cytogenet 42: 43-50, 1989.
8. Osella P, Carlson A, Wyandt H, Milunsky A: Cytogenetic studies of eight squamous cell carcinomas of the head and neck. Deletion of 7q, a possible primary chromosomal event. Cancer Genet Cytogenet 59: 73-78, 1992.
9. Atkin NB, Baker C: Chromosome 7q deletions: observations on 13 malignant tumors. Cancer Genet Cytonenet 67: 123-125, 1993.
10. Kere J, Donis-keller H, Ruutu T, de la Chapelle A: Chromosome 7 long-arm deletions in myeloid disorders: terminal DNA sequences are commonly conserved and breakpoints vary. Cytogenet Cell Genet 50: 226-229, 1989.
11. Neuman WL, Rubin CM, Rios RB, Larson RA, Le Beau MM, Rowley JD, Vardiman JW, Schwartz JL, Farber RA: Chromosomal loss and deletion are the most common mechanisms for loss of heterozygosity from chromosomes 5 and 7 in malignant mycloid disorders. Blood 79: 1501-1510, 1992.
12. Kuniyasu H, Yasui W, Yokozaki H, Akagi M, Akama Y, Kitahara K, Fujii K, Tahara E: Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas. Int J Cancer 59: 597-600, 1994.
13. Zenklusen JC, Thompson JC, Troncoso P, Kagan J, Conti CJ: Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. Cancer Res 54: 6370-6373, 1994.
14. Zenklusen JC, Thompson JC, Klein-Szanto AJP, Conti CJ: Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res 55: 1347-1350, 1995.
15. Zenklusen JC, Weitzel JN, Ball HG, Conti CJ: Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene. Oncogene 11: 359-363, 1995.
16. Zenklusen JC, Bieche I, Lidereau R, Conti CJ: (C-A)n microsatellite repeal D7S522 is the most commonly deleted region in human primary breast cancer. Proc Natl Acad Sci USA 91: 12155-12158, 1994.
17. Devilee P, van Vliet M, van Sloun P, Dijkshoorn NK, Hermans J, Pearson PL, Cornelisse CJ: Allelotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q. Oncogene 6: 1705-1711, 1991.
18. Sato T, Tanigami A, Yamakawa K, Akiyama F, Kasumi F, Sakamoto G, Nakamura Y: Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res 50: 7184-7189, 1990.
19. Deng G, Chen LC, Schott DR, Thor A, Bhargava V, Ljung MB, Chew K, Smith HS: Loss of heterozygosity and p53 gene mutation in breast cancer. Cancer Res 54: 499-505, 1994.
20. Bieche I, Champeme MH, Matifas F, Hacene K, Callahan R, Lidereau R: Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. Lancet 339: 139-143, 1992.
21. Champeme MH, Bieche I, Beuzelin M, Lidereau R: Loss of heterozygosity on 7q31 occurs early during breast tumorigenesis. Genes Chrom Cancer 12: 304-306, 1995.
22. Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M: Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol 13: 6036-6043, 1993.
23. Zenklusen JC, Oshimura M, Barren JC, Conti CJ: Inhibition of tumorigenicity of a murine squamous cell carcinoma (SCC) cell line by a putative tumor suppressor gene on human chromosome 7. Oncogcne 9: 2817-2825, 1994.
24. Maniatis T, Fritsch EF, and Sambrook J: Molecular Cloning: A loboratory Manual. Cold Spring Harbor Laboratory Press, New York, 1982.
25. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 16: 1215, 1988.
26. Barkardóttir RB, Arason A, Egilsson V, Gudmundsson J, Jonasdottir A, Jóhannesdóttir G: Chromosome 17q-linkage seems to be infrequent in Icelandic families at risk of breast cancer. Acta Oncol 34: 657-662, 1995.
27. Jonasson JG, Hrafnkelsson J: Nuclear DNA analysis and prognosis in carcinoma of the thyroid gland. Virchows Archiv 425: 349-355, 1994.
28. Eiriksdottir G, Bergthorsson JT, Sigurdsson H, Gudmundsson J, Skirnisdottir S, Egilsson V, Barkardottir RB, Ingvarsson S: Mapping of chromosome 3 alterations in human breast cancer using microsatellite PCR markers: Correlation with clinical variables. Int J Oncol 6: 369-375, 1995.
29. Bragadottir G, Eiriksdottir G, Sigurdsson A, Barkardottir RB, Gudmundsson J, Jonasson JG, Ingvarsson S: Loss of heterozygosity at chromosome 6q correlates with tumour progression and patient survival. Int J Oncol 7: 871-876, 1995.
30. Eiriksdottir G, Sigurdsson A, Jonason JG, Agnarsson BA, Sigurdsson H, Gudmundsson J, Bergthorsson JT, Barkardottir RB, Egilsson V, Ingvarsson S: Loss of heterozygosity on chromosome 9 in human breast cancer: Association with clinical variables and genetic changes at other chromosome regions. Int J Cancer 64: 378-382, 1995.
31. Gudmundsson J, Barkardottir RB, Eiriksdottir G, Baldursson T, Arason A, Egilsson V, Ingvarsson S: Loss of heterozygosity at chromosome in breast cancer: association of prognostic factors with genetic alterations. Br J Cancer 72: 696-701, 1995.
32. Skirnisdottir S, Eiriksdottir G, Baldursson T, Barkardottir RB, Egilsson V, Ingvarsson S: High frequency of allelic imbalance at chromosome region 16q22-23 in human breast cancer: correlation with high PgR and low S phase. Int J Cancer 64: 112-116, 1995
33. Sigurdsson H, Baldertorp B, Borg Å, Dalberg M, Ferno M, Killander D, Olsson H: Indicators of prognosis in node-negative breast cancer. N Engl J Med 322: 1045-1053, 1990.