Regulation of citrulline recycling in nitric oxide-dependent neurotransmission in the murine proximal colon

British Journal of Pharmacology

Volumn 120, Issue 4, 1997, Pages 707-713

  Shuttleworth, C W R ^a   Conlon, S B ^a   Sanders, K M ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Arginine; Argininosuccinate; Citrulline; Colon; Enteric nervous system; Gastrointestinal motility; Inhibitory junction potential; Nitric oxide

Indexed keywords

ARGININE; ARGININE METHYL ESTER; ATROPINE; CITRULLINE; NIFEDIPINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

AMINO ACID METABOLISM; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; FEMALE; HYPERPOLARIZATION; MALE; MICROELECTRODE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ARGININE; CITRULLINE; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FEMALE; MALE; MICE; MICE, INBRED BALB C; MUSCLE, SMOOTH; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE; SUBSTRATE CYCLING; SYNAPTIC TRANSMISSION; THIOUREA;

EID: 0031047613     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700949     Document Type: Article

References (31)

1. AOKI, E., SEMBA, R. & KASHIWAMATA, S. (1991). Evidence for the presence of L-arginine in the glia components of the peripheral nervous system. Brain Res., 559, 159-162.
2. BOECKXSTAENS, G.E., PELCKMANS, P.A., HERMAN, A.G. & VAN MAERCKE, Y.M. (1993). Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology, 104, 690-697.
3. BREDT, D.S. & SNYDER, S.H. (1989). Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. U.S.A., 86, 9030-9033.
4. BULT, H., BOECKXSTAENS, G.E., PELCKMANS, P.A., JORDAENS, F.H., VAN MAERCKE, Y.M. & HERMAN, A.G. (1990). Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature, 345, 346-347.
5. CHEN, F.Y. & LEE, T.J. (1995). Arginine synthesis from citrulline in perivascular nerves of cerebral artery. J. Pharmacol. Exp. Ther., 273, 895-901.
6. CONLON, S.B., SANDERS, K.M. & SHUTTLEWORTH, C.W.R. (1996). Effects of citrulline on nitric oxide-dependent neuromuscular transmission in murine colon. Gastroenterology, 110, A1064 (Abstract).
7. DALZIEL, H.H., THORNBURY, K.D., WARD, S.M. & SANDERS, K.M. (1991). Involvement of nitric oxide synthetic pathway in inhibitory junction potentials in canine proximal colon. Am. J. Physiol., 260, G789-G792.
8. ELLIS, J.L. & CONANAN, N. (1994). L-citrulline reverses the inhibition of nonadrenergic, noncholinergic relaxations produced by nitric oxide synthase inhibitors in guinea-pig trachea and human bronchus. J. Pharmacol. Exp. Ther., 269, 1073-1078.
9. FURFINE, E.S., HARMON, M.F., PAITH, J.E., KNOWLES, R.G., SALTER, M., KIFF, R.J., DUFFY, C., HAZELWOOD, R., OPLINGER, J.A. & GARVEY, E.P. (1994). Potent and selective inhibition of human nitric oxide synthases. J. Biol. Chem., 269, 26677-26683.
10. G-nitroarginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle. Br. J. Pharmacol., 99, 602-606.
11. GOLDHILL, J.M. FINKELMAN, F.D., MORRIS, S.C. & SHEADONOHUE, T. (1995). Neural control of mouse small intestinal longitudinal muscle: interactions with inflammatory mediators. J. Pharmacol. Exp. Ther., 274, 72-77.
12. HOYLE, C.H.V. & BURNSTOCK, G. (1989). Neuromuscular transmission in the gastrointestinal tract. In Handbook of Physiology, Sect. 6: The Gastrointestinal System. ed. Makhlouf, G.M. pp. 435-464. Washington D.C.: American Physiological Society.
13. KEEF, K.D., DU, C., WARD, S.M., MCGREGOR, D.B. & SANDERS, K.M. (1993). Enteric inhibitory neural control of human colon: role of nitric oxide. Gastroenterology, 105, 1009-1016.
14. LEDOW, A., MURRAY, J., CLARK, E.D. & CONKLIN, J.L. (1996). L-Citrulline reverses NOS inhibition in opossum esophagus: substrate recycling? Gastroenterology, 110, A703 (Abstract).
15. LOMAX, A.E., HARNEY, S.C., JACKSON, V.M. & WARD, S.M. (1996). Interaction of inhibitory neurotransmitters regulate electrical and mechanical activity in the murine colon. Gastroenterology, 110, A709 (Abstract).
16. LYSTER, D.J., BYWATER, R.A. & TAYLOR, G.S. (1995). Neurogenic control of myoelectric complexes in the mouse isolated colon. Gastroenterology, 108, 1371-1378.
17. MCCONALOGUE, K., FURNESS, J.B., VREMEC, M.A., HOLST, J.J., TORNOE, K. & MARLEY, P.D. (1995). Histochemical, pharmacological, biochemical and chromatographic evidence that pituitary adenylyl cyclase activating peptide is involved in inhibitory neurotransmission in the taenia of the guinea-pig caecum. J. Auton. Nerv. Syst., 50, 311-322.
18. NARAYANAN, K., SPACK, L., MCMILLAN, K., KILBOURN, R.G., HAYWARD, M.A., MASTERS, B.S.S. & GRIFFITH, O.W. (1995). S-Alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo. J. Biol. Chem., 270, 11103-11110.
19. OKASORA, T., BYWATER, R.A. & TAYLOR, G.S. (1986). Projections of enteric motor neurons in the mouse distal colon. Gastroenterology, 90, 1964-1971.
20. PATEJUNAS, G., BRADLEY, A., BEAUDET, A.L. & O'BRIEN, W.E. (1994). Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene. Somat. Cell Mol. Genet., 20, 55-60.
21. RAND, M.J. & LI, C.G. (1995). Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission. Ann. Rev. Physiol., 57, 659-682.
22. RATNER, S. (1973). Enzymes of arginine and urea synthesis. Adv. Enzymol., 39, 1-90.
23. SANDERS, K.M. & SMITH, T.K. (1986). Enteric neural regulation of slow waves in circular muscle of the canine proximal colon. J. Physiol., 377, 297-313.
24. SANDERS, K.M. & WARD, S.M. (1992). Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am. J. Physiol., 262, G379-G392.
25. SANG, Q. & YOUNG, H.M. (1996). Chemical coding of neurons in the myenteric plexus and external muscle of the small and large intestine of the mouse. Cell Tissue Res., 284, 39-53.
26. SHUTTLEWORTH, C.W.R., BURNS, A.J., WARD, S.M., O'BRIEN, W.E. & SANDERS, K.M. (1995). Recycling of L-citrulline to sustain nitric oxide-dependent enteric neurotransmission. Neuroscience, 68, 1295-1304.
27. SHUTTLEWORTH, C.W.R. & KEEF, K.D. (1995). Roles of peptides in enteric neuromuscular transmission. Regul. Pept., 56, 101-120.
28. SHUTTLEWORTH, C.W.R. & SANDERS, K.M. (1996). Involvement of nitric oxide in neuromuscular transmission in canine proximal colon. Proc. Soc. Exp. Biol. Med., 21, 16-23.
29. STARK, M.E., BAUER, A.J., SARR, M.G. & SZURSZEWSKI, J.H. (1993). Nitric oxide mediates inhibitory nerve input in human and canine jejunum. Gastroenterology, 104, 398-409.
30. STARK, M.E., BAUER, A.J. & SZURSZEWSKI, J.H. (1991). Effect of nitric oxide on circular muscle of the canine small intestine. J. Physiol., 444, 743-761.
31. STARK, M.E. & SZURSZEWSKI, J.H. (1992). Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology, 103, 1928-1949.