Analytical description of the activation of multi-state receptors by continuous neurotransmitter signals at brain synapses

Biophysical Journal

Volumn 72, Issue 3, 1997, Pages 1127-1134

  Uteshev, Vladimir V ^a   Pennefather, Peter S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMATE RECEPTOR; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID; NEUROTRANSMITTER;

ARTICLE; CELL COMMUNICATION; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; INTERNEURON; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPSE VESICLE; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION;

EID: 0031047254     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78761-7     Document Type: Article

References (18)

1. Bartol, T. M., Jr., B. R. Land, E. E. Salpeter, and M. M. Salpeter. 1991. Monte Carlo simulation of miniature endplate current generation in the vertebrate neuromuscular junction. Biophys. J. 59:1290-1307.
2. Colquhoun, D., and A. G. Hawkes. 1977. Relaxation and fluctuations of membrane currents that flow through drug-operating ion channels. Proc. R. Soc. Lond. B. 199:231-262.
3. Colquhoun, D., and A. G. Hawkes. 1995. The principles of the stochastic interpretation of ion-channel mechanisms. In Single-Channel Recording, B. Sakmann and E. Neher, editors. Plenum Publishing Corp., New York and London. 397-479.
4. Holmes, W. R. 1995. Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation. Biophys. J. 69:1734-1747.
5. Jonas, P., G. Major, and B. Sakmann. 1993. Quantal components of unitary EPSCs at the mossy fiber synapse on CA3 pyramidal cells of rat hippocampus. J. Physiol. 472:615-663.
6. Khanin, R., H. Parnas, and L. Segel. 1994. Diffusion cannot govern the discharge of neurotransmitter in fast synapses. Biophys. J. 67:966-972.
7. Kullmann, D. M. 1994. Amplitude fluctuations of dual component EPSCs in hippocampal pyramidal cells: implications for long-term potentiation. Neuron. 12:1111-1120.
8. Kullmann, D. M., G. Erdemli, and F. Asztely. 1996. LTP of AMPA and NMDA receptor mediated signals: evidence for presynaptic expression and extrasynaptic glutamate spill-over. Neuron. 17:461-474.
9. Land B. R., E. E. Salpeter, and M. M. Salpeter. 1981. Kinetic parameters for acetylcholine interaction in intact neuromuscular junction. Proc. Natl. Acad. Sci. USA. 78:7200-7204.
10. Lester, R. A. J., and C. E. Jahr. 1992. NMDA channel behavior depends on agonist affinity. J. Neurosci. 12:635-643.
11. Ortega, J. M., and W. G. Poole. 1981. An Introduction to Numerical Methods for Differential Equations. Pitman, Boston.
12. Rubinstein, R. Y. 1981. Simulation and the Monte Carlo Method. John Wiley & Sons, New York.
13. Sakmann, B., and E. Neher. 1995. Single-Channel Recording. Plenum Publishing Corp., New York and London.
14. Stiles, J. R., D. van Helden, T. M. Bartol, Jr., E. E. Salpeter, and M. M. Salpeter. 1996. Miniature endplate current rise time <100 ms from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle. Proc. Natl. Acad. Sci. USA. 93: 5747-5752.
15. Uteshev, V. V., and P. S. Pennefather. 1996a. Phasic activation and state-dependent inhibition: an explicit solution for a three-state ion channel system. J. Theor. Biol. 181:11-23.
16. Uteshev, V. V., and P. S. Pennefather. 1996b. A mathematical description of mPSC generation at CNS synapses. Biophys. J. 71:1256-1266.
17. Van der Kloot, W. 1995. The rise time of miniature endplate currents suggest that acetylcholine may be released over a period of time. Biophys. J. 69:148-154.
18. Wathey, J. C., M. M. Nass, and H. A. Lester. 1979. Numerical reconstruction of the quantal event of nicotinic synapses. Biophys. J. 27:145-164.