Evidence of apoptosis in neuroblastoma at onset and relapse. An analysis of a large series of tumors

Journal of Neuro-Oncology

Volumn 31, Issue 1-2, 1997, Pages 209-215

  Tonini, Gian Paolo ^a,b,c   Mazzocco, Katia ^a   Di Vinci, Angela ^c   Geido, Elio ^c   De Bernardi, Bruno ^d   Giaretti, Walter ^c  

^a Laboratory of Oncology   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c ADVANCED BIOTECHNOLOGY CENTER   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

Apoptosis; DNA fragmentation; Flow cytometry; N myc; Neuroblastoma; Terminal deoxynucleotidyl Transferase

Indexed keywords

CELL NUCLEUS DNA; DNA FRAGMENT;

APOPTOSIS; ARTICLE; CANCER REGRESSION; CANCER STAGING; CELL CYCLE PHASE; CONTROLLED STUDY; DNA CONTENT; DNA DEGRADATION; FLOW CYTOMETRY; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; METASTASIS; MORTALITY; NEUROBLASTOMA; ONCOGENE C MYB; PLOIDY; RELAPSE;

APOPTOSIS; DNA FRAGMENTATION; DNA, NEOPLASM; ELECTROPHORESIS, AGAR GEL; FLOW CYTOMETRY; GENES, MYC; HUMANS; LONGITUDINAL STUDIES; NEOPLASM STAGING; NEUROBLASTOMA; RECURRENCE; S PHASE; SENSITIVITY AND SPECIFICITY;

EID: 0031046785     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Tonini GP: Neuroblastoma: the result of multistep transformation? Stem Cells 11: 276-282, 1993
2. Gilbert F, Feder M, Balabam G, Brangman D, Lurie D, Podolsky R, Rinaldt V, Vinikoor N, Weisband J: Human neuroblastoma and abnormalities of chromosome 1 and 17. Cancer Res 44: 5444-5449, 1984
3. Fong CT, Dracopoli NC, White PS, Merril PT, Griffith RC, Housman DE, Brodeur GM: Loss of heterozygosity for short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci USA 86: 3753-3757, 1989
4. Lathi JM, Valentine M, Xiang J Heath LS, Campana D, Kidd VJ: Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet 7: 370-375, 1994
5. Reed JC, Meister L, Tanaka S, Cuddy M, Yum S, Geyer C, Pleasure D: Differential expression of bc12 protooncogene in neuroblastoma and other human tumor cell lines of neural origin. Cancer Res 51: 6529-6538, 1991
6. Castle VP, Heidelberger KP, Bromberg J, Ou X, Dole M, Nunez G: Expression of the apoptosis-suppressing protein bcl-2 in neuroblastoma is associated with unfavorable histology and N-myc amplification. Am J Pathol 143: 1543-1550, 1993
7. Gorczyca W, Bigman K, Mittelman A, Ahmed T, Gong J, Melamed ML, Darzynkiewicz Z: Induction of DNA strand breaks with apoptosis during treatment of leukemias. Leukemia 7: 659-670, 1993
8. Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462, 1995
9. Gorczyca W, Gong J, Darzynkiewicz Z: Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal-deoxynucleotidyl-transferase and nick-translation assays. Cancer Res 53: 1945-1951, 1993
10. Oberhammer F, Wilson JW, Dive C: Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50-kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 12: 3679-3684, 1993
11. Wyllie AH: Apoptosis (the 1992 Frank Rose Memorial Lecture) Br J Cancer 67: 205-208, 1993
12. Fukasawa Y, Ishikura H, Takada A, Yokoyama S, Iamamura M, Yoshiki T, Sato H: Massive apoptosis in infantile myofibromatosis. A putative mechanism of tumor regression. Am J Pathol 144: 480-485, 1994
13. Pritchard J, Hickman JA: Why does stage 4S neuroblastoma regress spontaneously? Lancet 344: 869-870, 1994
14. Oppenheim RW: Cell death during development of the neurvous system. Annu Rev Neurosci 14: 453-501, 1991
15. Tonini GP: Report of the Italian Pediatric Cancer Research Group on the Neuroblastoma Research Programme. Eur J Cancer 28A: 1000-1001, 1993
16. Tonini GP, Verdona G, De Bernardi B, Sansone R, Massimo L, Cornaglia-Ferraris P: N-myc oncogene amplification in a patient with IV-S neuroblastoma. Am J Hematol/Oncol 9: 8-10, 1987
17. Feinberg AP, Vogelstein B: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Addendum Ann Biochem 137: 266-267, 1984
18. Gravieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119: 493-501, 1992
19. Giaretti W, Nusse M, Bruno S, Di Vinci A, Geido E: A new method to discriminate G1, S, G2; M, and G1 post-mitotic cells. Exp Cell Res 182: 290-295, 1989
20. Giaretti W: A model of DNA aneuploidization and evolution in colorectal cancer. Lab Invest 71: 904-910, 1994
21. Di Vinci A, Geido E, Infusini E, Giaretti W: Neuroblastoma cell apoptosis induced by the synthetic retinoid N-(4-hydroxyphenyl)retinamide. Int J Cancer 59: 422-426, 1994
22. Ponzoni M, Bocca P, Chiesa V, Decensi A: Differential effects of N-(4-hydroxyphenyl)retinamide and retinoic acid on neuroblastoma cells: Apoptosis versus differentiation. Cancer Res 55: 853-856, 1995
23. Haas D, Ablin AR, Miller C: Complete pathologic maturation and regression of stage IVS neuroblastoma without treatment. Cancer 62: 818-825, 1988