Charged amino acids near the pore entrance influence ion-conduction of a human L-type cardiac calcium channel

Molecular and Cellular Biochemistry

Volumn 166, Issue 1-2, 1997, Pages 125-134

  Bahinski, Anthony ^b   Yatani, Atsuko ^a   Mikala, Gabor ^c   Tang, Shaoqing ^d   Yamamoto, Satoshi ^e   Schwartz, Arnold ^a,c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Ca2+ affinity; Mg2+ binding; Pore vestibule; Pore lining region; Single channel conductance

Indexed keywords

ASPARTIC ACID; BARIUM ION; CALCIUM CHANNEL; CALCIUM ION; DIVALENT CATION; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; LITHIUM ION; MAGNESIUM ION; MEMBRANE PROTEIN; SODIUM ION;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CALCIUM CONDUCTANCE; CONTROLLED STUDY; HEART; HUMAN; MUTANT; NONHUMAN; OOCYTE; XENOPUS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ASPARTIC ACID; CALCIUM; CALCIUM CHANNELS; ELECTRIC CONDUCTIVITY; GLUTAMIC ACID; HEART; HUMANS; LYSINE; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS;

ANIMALIA;

EID: 0031045617     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006847632410     Document Type: Article

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