Effect of heparin loading during congenital heart operation on thrombin generation and blood loss

Annals of Thoracic Surgery

Volumn 63, Issue 2, 1997, Pages 482-488

  Turner Gomes, Sophronia O ^a   Nitschmann, Evan P ^b   Norman, Geoffrey R ^b   Andrew, Maureen E ^b   Williams, William G ^b  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; THROMBIN;

ADOLESCENT; ARTICLE; CARDIOPULMONARY BYPASS; CHILD; CLINICAL ARTICLE; CONGENITAL HEART DISEASE; CYANOSIS; HEART SURGERY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL;

ADOLESCENT; ANTICOAGULANTS; BLOOD LOSS, SURGICAL; CARDIOPLEGIC SOLUTIONS; CARDIOPULMONARY BYPASS; CHILD; CHILD, PRESCHOOL; HEART DEFECTS, CONGENITAL; HEMODILUTION; HEPARIN; HUMANS; INFANT; PEPTIDE FRAGMENTS; PROTHROMBIN; THROMBIN;

EID: 0031045538     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(96)01215-5     Document Type: Article

References (20)

1. Dobell ARC, Trusler GA, Smallhorn JF, Williams WG. Atrial thrombi after the Fontan operation. Ann Thorac Surg 1986; 42:664-7.
2. Tamisier D, Vouhé PR, Vernant F, Leca F, Massot C, Neveux J-Y. Modified Blalock-Taussig shunts: results in infants less than 3 months of age. Ann Thorac Surg 1990;49:797-801.
3. Coles JG, Kielmanowicz S, Freedom RM, et al. Surgical experience with the modified Fontan procedure. Circulation 1987;76(Suppl 3):61-6.
4. Okita Y, Miki S, Kusuhara K, et al. Massive systemic venous thrombosis after Fontan operation: report of a case. Thorac Cardiovasc Surg 1988;36:234-6.
5. Turner-Gomes S, Nitschmann E, Benson L, Burrows P, Andrew M. Heparin is cleared faster in children with congenital heart disease than in adults. J Am Coll Cardiol 1993;21:59A.
6. Turner-Gomes SO, Mitchell L, Williams WG, Andrew M. Thrombin regulation in congenital heart disease after cardiopulmonary bypass operations. J Thorac Cardiovasc Surg 1994;107:562-8.
7. Fenton JW II. Regulation of thrombin generation and functions. Semin Thromb Hemost 1988;14:234-40.
8. Ofosu FA, Gray E. Mechanisms of action of heparin. Semin Thromb Hemost 1988;14:9-17.
9. Ofosu FA, Cerskus AL, Hirsh J, Smith LM, Modi GJ, Blajchman MA. The inhibition of the anticoagulant activity of heparin by platelets, brain phospholipids, and tissue factor. Br J Haematol 1984;57:229-38.
10. Pelzer H, Schwarz A, Heimburger N. Determination of human thrombin-antithrombin III complex in plasma with an enzyme-linked immunosorbent assay. Thromb Haemost 1988;59:101-6.
11. Pelzer H, Schwarz A, Stüber W. Determination of human prothrombin activation fragment 1+2 in plasma with an antibody against a synthetic peptide. Thromb Haemost 1991; 65:153-9.
12. Rowbotham BJ, Carroll P, Whitaker AN, et al. Measurement of crosslinked fibrin derivatives - use in the diagnosis of venous thrombosis. Thromb Haemost 1987;57:59-61.
13. Abildegaard U, Lie M, Odegard OR. Antithrombin (heparin cof actor) assay with "new" chromogenic substrates (S2238 and Chromozym TH). Thromb Res 1977;11:549-53.
14. Teien AN, Lie M, Abildegaard U. Assay of heparin in plasma using a chromogenic substrate for activated factor X. Thromb Res 1976;8:413-6.
15. Saleem A, Shenaq SS, Yawn DH, et al. Heparin monitoring during cardiopulmonary bypass. Ann Clin Lab Sci 1984;14: 474-9.
16. Culliford AT, Gitel SN, Starr N, et al. Lack of correlation between activated clotting time and plasma heparin during cardiopulmonary bypass. Ann Surg 1981;193:105-11.
17. Addonizio VP Jr, Smith JB, Strauss JF III, Colman RW, Edmunds LH Jr. Thromboxane synthesis and platelet secretion during cardiopulmonary bypass with bubble oxygenator. J Thorac Cardiovasc Surg 1980;79:91-6.
18. Bick RL. Hemostatic defects associated with cardiac surgery, prosthetic devices, and other extracorporeal circuits. Semin Thromb Hemost 1985;11:249-80.
19. Mammen EF, Koets MH, Washington BC, et al. Hemostasis changes during cardiopulmonary bypass surgery. Semin Thromb Hemost 1985;11:281-92.
20. Horkay F, Martin P, Rajah SM, Walker DR. Response to heparinization in adults and children undergoing cardiac operations. Ann Thorac Surg 1992;53:822-6.