Efficacy and mechanisms of dopexamine in the prevention of ischemia-reperfusion induced organ damage: Role of oxygen free radicals

Clinical and Experimental Hypertension

Volumn 19, Issue 1-2, 1997, Pages 181-190

  Jacinto, Severina M ^a   Chintala, Madhu S ^a   Lokhandwala, Mustafa F ^a   Jandhyala, Bhagavan S ^a  

^a UNIVERSITY OF HOUSTON   (United States)

Author keywords

dopamine 1 (DA 1) receptor; dopexamine; hemorrhagic shock; oxygen free radicals; renal function; 2 adrenoceptor

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOBUTAMINE; DOPAMINE 1 RECEPTOR; DOPEXAMINE; FENOLDOPAM; FREE RADICAL; ICI 558551; OXYGEN RADICAL; PRENALTEROL; SALBUTAMOL; UNCLASSIFIED DRUG; XANTHINE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; CHRONOTROPISM; CONFERENCE PAPER; DOG; HEMORRHAGIC SHOCK; INOTROPISM; INTRAVENOUS DRUG ADMINISTRATION; ISCHEMIA; KIDNEY BLOOD FLOW; KIDNEY FAILURE; KIDNEY FUNCTION; NONHUMAN; REPERFUSION;

EID: 0031045536     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.3109/10641969709080814     Document Type: Conference Paper

References (12)

1. 2+ gain during reoxygenation after hypoxia in rabbit myocardium. Am. J. Physiol., 242:H437-H449, 1982.
2. Hamcas, A., Park, C.-K., Palazzo, R., Liptay, M., Cooper, J., Schuster, D. P.: Modifying pulmonary ischemia-reperfusion injury by altering ventilatory strategies during ischemia. J. Appl. Physiol., 73(5):2112-2119, 1992.
3. 2-ventilated canine pulmonary lobe. J. Appl. Physiol., 63(1):111-115, 1987.
4. Cheung, J. Y., Bonventre, J. V., Malis, C. D., Leaf, A.: Calcium and ischemic injury. N. Engl. J. Med., 26:1670-1676, 1986.
5. Hearse, D. J., Tosaki, A.: Free radicals and calcium: Simultaneous interacting triggers as determinants of vulnerability to reperfusion-induced arrhythmias in the rat heart. J. Mol. Cell Cardiol., 20:213-223, 1988.
6. Hearse, D. J., Humphrey, S. M., Bullock, G. R.: The oxygen paradox and the calcium paradox: Two facets of the same problem? J. Mol. Cell. Cardiol., 10:641-668, 1978.
7. 2-adrenoreceptors. Br. J. Pharmacol., 85:599-608, 1985.
8. Farmer, J. B.: Research into the cardiovascular effects of dopexamine hydrochloride. Clin. Inten. Care, 2:9-11, 1991.
9. Chintala, M. S., Jandhyala, B. S.: Renal failure in hemorrhagic shock in dogs: Salutary effects of the calcium entry blocker felodipine. Naunyn-Schmiedeberg's Arch. Pharmacol., 341:357-363, 1989.
10. Jacinto, S. M., Jandhyala, B. S.: Evaluation of the effects of felodipine, verapamil and hydralazine on the survival rate of rats subjected to lethal effects of oxygen free radicals. Naunyn-Schmiedeberg's Arch. Pharmacol., 346:457-461, 1992.
11. Rao, P. S., Cohen, M. V., Mueller, H. S.: Production of free radicals and lipid peroxides in early experimental myocardial ischemia. J. Mol. Cell. Cardiol., 15:713-716, 1983.
12. Halliwell, B., Chirico, S.: Lipid peroxidation: Its mechanism, measurement and significance. Am. J. Clin. Nutr., 57(Suppl):15S-25S, 1993.