Ocular membrane permeability of hydrophilic drugs for ocular peptide delivery

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 2, 1997, Pages 135-139

  Sasaki, Hitoshi ^a   Ichikawa, Masataka ^a   Yamamura, Kenzo ^a   Nishida, Koyo ^a   Nakamura, Junzo ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; PARANITROPHENYL BETA CELLOPENTAOSIDE; PEPTIDE; PROTIRELIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONJUNCTIVA; CONJUNCTIVA EPITHELIUM; CORNEA; CORNEA EPITHELIUM; CORNEA PERMEABILITY; DRUG ABSORPTION; DRUG DIFFUSION; DRUG PENETRATION; HYDROPHILICITY; MALE; MEMBRANE PERMEABILITY; MOLECULAR WEIGHT; NONHUMAN; RABBIT;

EID: 0031045146     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06767.x     Document Type: Article

References (20)

1. Ahmed, I., Patton, T. F. (1987) Disposition of timolol and inulin in the rabbit eye following corneal versus non-corneal absorption. Int. J. Pharm. 38: 9-21
2. Chien, D.-S., Bundgaard, H., Lee, V. H. L. (1988) Influence of corneal epithelial integrity on the penetration of timolol prodrugs. J. Ocul. Pharmacol. 4: 137-146
3. Chiou, G. C. Y., Chuang, C. Y. (1989) Improvement of systemic absorption of insulin through eyes with absorption enhancers. J. Pharm. Sci. 78: 815-818
4. Grass, G. M., Robinson, J. R. (1984) Relationship of chemical structure to corneal penetration and influence of low-viscosity solution on ocular bioavailability. J. Pharm. Sci. 73: 1021-1027
5. Grass, G. M., Robinson, J. R. (1988a) Mechanisms of corneal drug penetration I: in vivo and in vitro kinetics. J. Pharm. Sci. 77: 3-14
6. Grass, G. M., Robinson, J. R. (1988b) Mechanisms of corneal drug penetration II: ultrastructural analysis of potential pathways for drug movement. J. Pharm. Sci. 77: 15-23
7. Grass, G. M., Cooper, E. R., Robinson, J. R. (1988) Mechanisms of corneal drug penetration III: modeling of molecular transport. J. Pharm. Sci. 77: 24-26
8. Harris, D., Liaw, J.-H., Robinson, J. R. (1992) Ocular delivery of peptide and protein drugs. Adv. Drug Del. Rev. 8: 331-339
9. Huang, H.-S., Schoenwald, R. D., Lach, J. L. (1983) Corneal penetration behavior of β-blocking agents II: assessment of barrier contributions. J. Pharm. Sci. 72: 1272-1279
10. Huang, A. J. W., Tseng, S. C. G., Kenyon, K. R. (1989) Paracellular permeability of corneal and conjunctival epithelia. Invest. Ophthalmol. Vis. Sci. 30: 684-689
11. Lee, V. H. L., Carson, L. W., Kashi, S. D., Stratford, R. E. (1986) Metabolic and permeation barriers to the ocular absorption of topically applied enkephalins in albino rabbits. J. Ocul. Pharmacol. 2: 345-352
12. Lee, V. H. L., Chien, D.-S., Sasaki, H. (1988) Ocular ketone reductase distribution and its role in the metabolism of ocularly applied levobunolol in the pigmented rabbit. J. Pharmacol. Exp. Ther. 246: 871-878
13. Maurice, D. M. (1960) The movement of fluorescein and water in the cornea. Am. J. Ophthalmol. 49: 1011-1016
14. Rojanasakul, Y., Paddock, S. W., Robinson, J. R. (1990) Confocal laser scanning microscopic examination of transport pathways and barriers of some peptides across the cornea. Im. J. Pharm. 61: 163-172
15. Sasaki, H., Igarashi, Y., Nishida, K., Nakamura, J. (1993) Ocular delivery of the β-blocker, tilisolol, through the prodrug approach. Int. J. Pharm. 93: 49-60
16. Sasaki, H., Igarashi, Y., Nagano, T., Yamamura, K., Nishida, K., Nakamura, J. (1995a) Penetration of β-blocker through ocular membranes in albino rabbits. J. Pharm. Pharmacol. 47: 17-21
17. Sasaki, H., Yamamura, K., Tei, C., Nishida, K., Nakamura, J. (1995b) Ocular permeability of FITC-dextran with absorption promoter for ocular delivery of peptide drug. J. Drug Targeting 3: 129-135
18. Schoenwald, R. D., Huang, H.-S. (1983) Corneal penetration behavior of β-blocking agents I: physicochemical factors. J. Pharm. Sci. 72: 1266-1272
19. Yamamoto, A., Luo, A. M., Dodda-Kashi, S., Lee, V. H. L. (1989) The ocular route for systemic insulin delivery in the albino rabbit. J. Pharmacol. Exp. Ther. 249: 249-255
20. Yano, Y., Yamaoka, K., Tanaka, H. (1989) A nonlinear least squares program, MULTI(FILT), based on fast inverse Laplace transform for microcomputers. Chem. Pharm. Bull. 37: 1035-1038