Studies on the metabolism and disposition of the new retinoid 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl] benzoic acid. 1st communication: Absorption, distribution, metabolism and excretion after topical application and subcutaneous administration in rats

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 1, 1997, Pages 59-69

  Mizojiri, Kenji ^a   Okabe, Hiroshi ^a   Sugeno, Koichi ^a   Esumi, Yoshio ^b   Takaichi, Matsuo ^b   Miyake, Takayuki ^b   Seki, Hideaki ^b   Inaba, Atsuhiro ^b  

^a SHIONOGI AND CO LTD   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

am 80, absorption, distribution, excretion, metabolism subcutaneous administration, topical application; antipsoriatics, topical; CAS 94497 51 5; retinobenzoic acid

Indexed keywords

ANTIPSORIASIS AGENT; CARBON 14; RETINOID; TAMIBAROTENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG FECES LEVEL; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIVER; MALE; NONHUMAN; RAT; SKIN; SUBCUTANEOUS DRUG ADMINISTRATION; TOPICAL DRUG ADMINISTRATION; WHOLE BODY AUTORADIOGRAPHY;

ADMINISTRATION, TOPICAL; ANIMALS; AUTORADIOGRAPHY; BENZOATES; BILE; BIOTRANSFORMATION; DERMATOLOGIC AGENTS; ENTEROHEPATIC CIRCULATION; FECES; FEMALE; HALF-LIFE; INJECTIONS, SUBCUTANEOUS; INTESTINAL ABSORPTION; MALE; RATS; RATS, SPRAGUE-DAWLEY; SKIN ABSORPTION; TETRAHYDRONAPHTHALENES; TISSUE DISTRIBUTION;

EID: 0031044993     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Lucek, R. W., Colburn, W. A., Clin. Pharmacokinet., 10, 38 (1985)
2. Kagechika, H., Kawachi, E., Hashimoto, Y. et al., J. Med. Chem., 31, 2182 (1988)
3. Hashimoto, Y., Kagechika, H., Kawachi, E. et al., Jpn. J. Cancer Res. (Gann) 79, 473 (1988)
4. Washitake, M., Yajima, T., Anmo, T. et al., Chem. Pharm. Bull. 21, 2444 (1973)
5. Sugeno, K., Mizojiri, K., Esumi, Y. et al., Xenobio. Metab. Dispos. 3, 41 (1988)
6. Sugeno, K., Mizojiri, K., Esumi, Y. et al., Xenobiot. Metab. Dispos. 5, 785 (1990) (Japanese)
7. Tateishi, M., Tomisawa, H., Nakamura, S. et al., Pharmacometrics 24, 339 (1982) (Japanese)
8. Hashimoto, S., Mizobuchi, M., Kuroda, T. et al., Xenobiotica 24, 1177 (1995)