Phenylbutazone pharmacokinetics and bioavailability in the Dromedary camel (camelus dromedarius)

Journal of Veterinary Pharmacology and Therapeutics

Volumn 20, Issue 1, 1997, Pages 54-60

  Kadir, A ^a   Ali, B H ^b   Hadrami, G A L ^b   Bashir, A K ^b   Landoni, M F ^a   Lees, P ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; OXYPHENBUTAZONE; PHENYLBUTAZONE; THROMBOXANE B2;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CAMEL; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0031044829     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1997.04427.x     Document Type: Article

References (51)

1. Akaike, H. (1976) An information criterion (AIC). Mathematic Science 14, 5-9.
2. Alexander, F. (1982) Effect of phenylbutazone on electrolyte metabolism in ponies. Veterinary Record 110, 271-272.
3. Ali, B.H. & Hassan, T. (1986) Some observations on the toxicosis of isometamidium chloride (samorin) in camels. Veterinary & Human Toxicology 28, 424-426.
4. Ali, B.H. (1988) A survey of some drugs commonly used in the camel. Veterinary Research Communications, 12, 67-75.
5. Ali, B.H. & El Sheikh, H.A. (1992) Drug metabolism in camels. Proceedings of the First International Camel Conference. (Eds.) W.R. Allen, A.J. Higgins, I.G. Mayhew, D.H. Snow and J.F. Wade, R & W. Publications (Newmarket) Ltd, pp. 379-381.
6. Boulos, B.M., Jenkins, W.L. & Davis, L.E. (1972) Pharmacokinetics of certain drugs in the domesticated goat. American Journal of Veterinary Research 33, 943-952.
7. Bruce, R.B., Maynard, W.R. & Dunning, L.K. (1974) Oxyphenbutazone and phenylbutazone determination in plasma and urine by GLC. Journal of Pharmaceutical Sciences 63, 446-448.
8. Burns, J.J., Rose, R.K., Chenkin, T., Goldman, A., Schulert, A. & Brodie, B.B. (1963) The physiological disposition of phenylbutazone (Butazolidin) in man and a method for its estimation in biological material. Journal of Pharmacology and Experimental Therapeutics 109, 346-357.
9. Cheng, Z., Welsh, E., Nolan, A. & McKellar, Q.A. (1996) Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats. Journal of Veterinary Pharmacology and Therapeutics in press.
10. Collins, L.G. & Tyler, D.E. (1984) Phenylbutazone toxicosis in the horse: a clinical study. Journal of the American Veterinary Medical Association 184, 699-703.
11. ○ (NIH) 72-333, ILS Dept. of Health, Education and Welfare, Chapter 8, pp.715-733.
12. Dayton, P.G., Israili, Z.H. & Perel, J.M. (1973) Influence of binding on drug metabolism and distribution. Annals of the New York Academy of Sciences 226, 172-194.
13. De Backer, P., Braeckman, R., Belpaire, F. & Debackere, M. (1980) Bioavailability and pharmacokinetics of phenylbutazone in the cow. Journal of Veterinary Pharmacology and Therapeutics 3, 29-33.
14. Eberhardson, B., Olsson, G., Appelgren, L.-E. & Jacobsson, S.-O. (1979) Pharmacokinetic studies of phenylbutazone in cattle. Journal of Veterinary Pharmacology and Therapeutics 2, 31-37.
15. Eltom, S.E., Guard, C.L. & Schwark, W.S. (1993) The effect of age on phenylbutazone pharmacokinetics, metabolism and plasma protein binding in goats. Journal of Veterinary Pharmacology and Therapeutics 16, 141-151.
16. Frey, H.H. & Rieh, B. (1981) Pharmacokinetics of naproxen in the dog. American Journal of Veterinary Research 42, 1615-1617.
17. Gahlot, T.K. (1992) Urethral rupture and subcutaneous infiltration of urine in camels (Camelus dromedarius). Proceedings of the First International Camel Conference. (Eds.) W.R. Allen, A.J. Higgins, I.G. Mayhew, D.H. Snow and J.F. Wade, R. & W. Publications (Newmarket) Ltd, pp. 353-355.
18. Gunson, D.E. (1983) Renal papillary necrosis in horses. Journal of the American Veterinary Medical Association 182, 263-266.
19. Gunson, D.E. & Soma, L.R. (1983) Renal papillary necrosis in horses after phenylbutazone and water deprivation. Veterinary Pathology 20, 603-610.
20. Homeida, A.M., El Amin, E.A., Adam, S.E.I. & Mahmound, M.M. (1981) Toxicity of diamiazine aceturate (Berenil) to camels. Journal of Comparative Pathology 91, 355-358.
21. Hvidberg, E.F. & Rasmussen, F. (1975) Pharmacokinetics of phenylbutazone and oxyphenbutazone in the pig. Canadian Journal of Comparative Medicine, 39, 80-88.
22. Lambert, M.B.T. & Kelly, P.P. (1978) The binding of phenylbutazone to bovine and horse serum albumin. Irish Journal of Medical Science 147, 193-196.
23. Lees, P. & Higgins, A.J. (1985) Clinical pharmacology and therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Veterinary Journal 17, 83-96.
24. Lees, P. & Higgins A.J. (1986) Effects of a phenylbutazone paste in ponies: model of acute nonimmune inflammation. American Journal of Veterinary Research 47, 2359-2363.
25. Lees, P., Creed, R.F.S., Gerring, E.E.L., Gould, P.W., Humphreys, D.J., Maitho, T.E. & Michell, A.R. (1983) Biochemical and haematological effects of phenylbutazone in horses. Equine Veterinary Journal 15, 158-167.
26. Lees, P., Taylor, J.B.O., Higgins, A.J. & Sharma, S.C. (1986a) Phenylbutazone and oxyphenbutazone distribution into tissue fluids in the horse. Journal of Veterinary Pharmacology and Therapeutics 9, 204-212.
27. Lees, P., Higgins, A.J., Mawhinney, I.C. & Reid, D.S. (1986b) Absorption of phenylbutazone from a paste formulation administered orally to the horse. Research in Veterinary Science 41, 200-206.
28. Lees, P., Taylor, J.B.O., Maitho, T.E., Millar, J.D. & Higgins, A.J. (1987a) Metabolism, excretion, pharmacokinetics and tissue residues of phenylbutazone in the horse. Cornell Veterinarian 77, 192-211.
29. Lees, P., Ewins, C.P., Taylor, J.B.O. & Sedgwick, A.D. (1987b) Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin. British Veterinary Journal 143, 462-476.
30. Lees, P., Ayliffe, T., Maitho, T.E. & Taylor, J.B.O. (1988) Pharmacokinetics, metabolism and excretion of phenylbutazone in cattle following intravenous, intramuscular and oral administration. Research in Veterinary Science 44, 57-67.
31. Lehmann, W., Wintzer, H.-J. & Frey, H.-H. (1981) Kinetik einiger analgetisch-antiinflammatorischer arzneimittel in serum und synovia beim pferd. Deutsche Tierarztliche Wochenschrift 88, 218-220.
32. MacAllister, C.G. (1983) Effects of toxic doses of phenylbutazone in ponies. American Journal of Veterinary Research 44, 2277-2279.
33. MacKay, R.J., French, T.W., Nguyen, H.T. & Mayhew, I.G. (1983) Effects of large doses of phenylbutazone administration to horses. American Journal of Veterinary Research 44, 774-780.
34. Meschter, C.L., Maylin, G.A. & Krook, L. (1984) Vascular pathology in phenylbutazone intoxicated horses. Cornell Veterinarian 74, 282-297.
35. Mills, P.C., Ng, J.C., Hrdlicka, J. & Auer, D.E. (1995) Disposition and urinary excretion of phenylbutazone in normal and febrile Greyhounds. Research in Veterinary Science 59, 261-266.
36. Nigam, J.M. (1992) Surgical disorders of the male urogenital system in the dromedary camel. Proceedings of the First International Camel Conference. (Eds.) W.R. Allen, A.J. Higgins, I.G. Mayhew, D.H. Snow and J.F. Wade, R. & W. Publications (Newmarket) Ltd, pp. 361-364.
37. Oukessou, M. & Zine-Filali, R. (1992) A comparative study of phenylbutazone kinetics in the dromedary camel and sheep. International Conference on Camel Research, Dubai, pp. 420-421.
38. Piperno, E., Ellis, D.J., Getty, S.M. & Brody, T.M. (1968) Plasma and urine levels of phenylbutazone in the horse. Journal of American Veterinary Medicine Association 153, 195-198.
39. Read, W.K. (1983) Renal medullary crest necrosis associated with phenylbutazone therapy in horses. Veterinary Pathology 20, 662-669.
40. Rose, R.J., Kohnke, J.R. & Baggot, J.D. (1982) Bioavailability of phenylbutazone preparations in the horse. Equine Veterinary Journal 14, 234-237.
41. Runkel, R., Chaplin, M. & Boost, G. (1972) Absorption, distribution, metabolism and excretion of naproxen in various laboratory animals and human subjects. Journal of Pharmaceutical Sciences 62, 703-708.
42. Schwark, W.S. (1992) Factors that affect drug disposition in food-producing animals during maturation. Journal of Animal Science 70, 3635-3645.
43. Snow, D.H., Bogan, J.A., Douglas, T.A. & Thompson, H. (1979) Phenylbutazone toxicity in ponies. Veterinary Record 105, 26-30.
44. Snow, D.H., Douglas, T.A., Thompson, H., Parkins, J.J. & Holmes, P.H. (1981) Phenylbutazone toxicosis in equidae: a biochemical and pathophysiologic study. American Journal of Veterinary Research 42, 1754-1759.
45. Snow, D.H. & Douglas, T.A. (1983) Studies on a new paste preparation of Phenylbutazone. Veterinary Record 112, 602-607.
46. Taylor, J.B., Walland, A., Lees, P., Gerring, E.L., Maitho, T.E. & Millar, J.D. (1983) Biochemical and haematological effects of a revised dosage schedule of phenylbutazone in horses. Veterinary Record 112, 599-602.
47. Toutain, P.L., Alvinerie, M. & Ruckebusch, Y. (1980) Pharmacocinetique et residus de la phenylbutazone chez la vache. Annals Recherche Veterinaire, 11, 391-397.
48. Traub, J.L., Gallina, A.M., B.D. Grant, Reed, S.M., Gavin, P.R. & Paulsen, L.M. (1983) Phenylbutazone toxicosis in the foal. American Journal of Veterinary Research 44, 1410-1418.
49. Williams, J., Smith, J.A., Boudinot, F.D. & Knight, A.P. (1990a) Pharmacokinetics of phenylbutazone given intravenously or orally in mature Holstein bulls. American Journal of Veterinary Research 51, 367-370.
50. Williams, J., Boudinot, F.D., Smith, J.A. & Knight, A.P. (1990b) Pharmacokinetics of phenylbutazone in mature Holstein bulls: steady-state kinetics after multiple oral dosing. American Journal of Veterinary Research 51, 371-375.
51. Yamaoka, K., Nakagawa, T. & Uno, T. (1978) Application of Akaike's Information Criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics 6, 165-175.