Cyclophilin A is present in rat germ cells and is associated with spermatocyte apoptosis

Biology of Reproduction

Volumn 56, Issue 2, 1997, Pages 439-446

  Wine, Robert N ^a   Ku, Warren W ^a,b   Li, Ling Hong ^a   Chapin, Robert E ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN A; NUCLEASE;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CELL DEATH; DNA DEGRADATION; ENZYME ACTIVITY; GERM CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOSOME; PACHYTENE; PRIORITY JOURNAL; RAT; SPERMATOCYTE;

AMINO ACID ISOMERASES; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARRIER PROTEINS; DNA FRAGMENTATION; ENDODEOXYRIBONUCLEASES; ETHYLENE GLYCOLS; KINETICS; MALE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDYLPROLYL ISOMERASE; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; SPERMATOZOA; TESTIS;

ANIMALIA;

EID: 0031044512     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod56.2.439     Document Type: Article

References (29)

1. Chapin RE, Dutton SL, Ross MD, Sumrell BM, Lamb IV JC. The effects of ethylene glycol monomethyl ether on testicular histology in F344 rats. J Androl 1984; 5:369-380.
2. Ku WW, Chapin RE. Spermatocyte toxicity of 2-methoxyethanol in vivo and in vitro: requirement for an intact seminiferous tubule structure for germ cell degeneration. Toxicol In Vitro 1994; 8:1191-1202.
3. Ku WW, Wine RN, Chae BY, Ghanayem BI, Chapin RE. Spermatocyte toxicity of 2-methoxyethanol (2-ME) in rats and guinea pigs: evidence for the induction of apoptosis. Toxicol Appl Pharmacol 1995; 134:100-110.
4. Montague JW, Gaido ML, Frye C, Cidlowski JA. A calcium dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin. Recombinant cyclophilins A, B, and C have nuclease activity. J Biol Chem 1994; 269:18877-18880.
5. Duke RC, Chervenak R, Cohen JJ. Endogenous endonuclease-induced DNA fragmentation: an early event in cell mediated cytolysis. Proc Natl Acad Sci USA 1983; 80:6361-6365.
6. Hallick RB, Chelm BK, Gray PW Orozco EM Jr. Use of aurintricarboxylic acid as a inhibitor of nucleases during nucleic acid isolation. Nucleic Acids Res 1977; 4:3055-3064.
7. Compton MM, Cidlowski JA. Identification of a glucocorticoid-induced nuclease in thymocytes. A potential "lysis gene" product. J Biol Chem 1987; 262:8288-8292.
8. 2B. J Biol Chem 1991; 266: 18580-18585.
9. Caron-Leslie L-AM, Schwartzman RA, Gaido ML, Compton MM, Cidlowski JA. Identification and characterization of glucocorticoid-regulated nuclease(s) in lymphoid cells undergoing apoptosis. J Steroid Biochem Mol Biol 1991; 40:661-671.
10. Wilm M, Shevchenko A, Houthaeve T, Breit S, Schweigerer L, Fotsis T, Mann M. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature 1996; 379:466-469.
11. Shevchenko A, Wilm M, Vorm O, Mann M. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Anal Chem 1996; 68:850-858.
12. Johnson KJ, Hall ES, Boekelheide K. 2,5-Hexanedione exposure alters the rat Sertoli cell cytoskeleton. Microtubules and seminiferous tubule fluid secretion. Toxicol Appl Pharmacol 1991; 111:432-442.
13. Leblond CP, Clermont Y. Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann NY Acad Sci 1952; 55:548-573.
14. Handschumacher RE, Harding MW, Rice J, Drugge RJ. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 1984; 226:544-547.
15. Galat A. Peptidylproline cis-trans-isomerases: immunophilins. Eur J Biochem 1993; 216:689-707.
16. Zydowsky LD, Ho SI, Baker CH, McIntyre K, Walsh CT. Overexpression, purification, and characterization of yeast cyclophilins A and B. Protein Sci 1992; 1:961-969.
17. Ryffel B, Woerly G, Greiner B, Haendler M, Mihatsch J, Foxwell BM. Distribution of the cyclosporine binding protein cyclophilin in human tissues. Immunology 1991; 72:399-404.
18. Price ER, Zydowsky LD, Jin M, Baker CH, McKeon FD, Walsh CT. Human cyclophilin B: a second cyclophilin gene encodes a peptidylprolyl isomerase with a signal sequence. Proc Natl Acad Sci USA 1991; 88:1903-1907.
19. Hacker J, Fischer G. Immunophilins: structure-function relationship and possible role in microbial pathogenicity. Mol Microbiol 1993; 10: 445-456.
20. Walsh CT, Zydowsky LD, McKeon FD. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem 1992; 267:13115-13118.
21. Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G. Specific interaction between cyclophilin and cyclic peptides. Biopolymers 1995; 36:273-281.
22. Krummrei U, Bang R, Schmidtchen R, Brune K, Bang H. Cyclophilin-A is a zinc dependent DNA binding protein in macrophages. FEBS Lett 1995; 371:47-51.
23. Danielson PE, Forss-Petter S, Brow MA, Calavetta L, Douglass J, Milner RJ, Sutcliffe JG. p1B15: A cDNA clone of the rat mRNA encoding cyclophilin. DNA 1988; 7:261-267.
24. Cossio G, Sanchez JC, Golaz O, Wettstein R, Hochstrasser DF. Spermatocytes and round spermatids of rat testis: protein patterns. Electrophoresis 1995: 16:1225-1230.
25. Rosenthal AL, Lacks SA. Detection of histones by DNA binding ability after polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. J Biol Chem 1978; 253:8674-8676.
26. Dunbar BS, Schwoebel ED. Preparation of polyclonal antibodies. In: Deutscher MP (ed.), Guide to Protein Purification. San Diego: Academic Press; 1990: 663-670.
27. Chatellard-Gruaz D, Saurat J-H, Siegenthaler G. Differential expression of cyclophilin isoforms during keratinocyte differentiation. Biochem J 1994; 303:863-867.
28. Creasy DM, Flynn JC, Gray TJB, Butler WH. A quantitative study of stage-specific spermatocyte damage following administration of ethylene glycol monomethyl ether in the rat. Exp Mol Pathol 1985; 43:321-337.
29. Montague JW, Cidlowski JA. Glucocorticoid-induced death of immune cells: mechanisms of action. In: Droemer G, Martinez-A C (eds.), Current Topics in Microbiology and Immunology, Vol. 200: Apoptosis in Immunology. Berlin Heidelberg: Springer-Verlag; 1995: 51-65.